Search Results - "CLERCH, L. B"

Tolerance of rats to hyperoxia : lung antioxidant enzyme gene expression by CLERCH, L. B, MASSARO, D

“…Tolerance to hyperoxia usually requires an increase of lung antioxidant enzyme (AOE) activity. We used rats with different degrees of tolerance to > 95% O2 to…”
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Retinoic acid receptor-beta: an endogenous inhibitor of the perinatal formation of pulmonary alveoli by Massaro, G D, Massaro, D, Chan, W Y, Clerch, L B, Ghyselinck, N, Chambon, P, Chandraratna, R A

“…Pulmonary alveoli are formed, in part, by subdivision (septation) of the gas-exchange saccules of the immature lung. Septation is developmentally regulated,…”
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Rat lung antioxidant enzymes: differences in perinatal gene expression and regulation by Clerch, L B, Massaro, D

“…The lung activity of the antioxidant enzymes (AOEs) copper, zinc superoxide dismutase (Cu,Zn SOD), catalase (CAT), and glutathione peroxidase (GP), but not…”
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Gene expression of cellular retinoid-binding proteins : Modulation by retinoic acid and dexamethasone in postnatal rat lung by WHITNEY, D, MASSARO, G. D, MASSARO, D, CLERCH, L. B

“…In rats, septation of gas-exchange saccules occurs during the first 2 postnatal weeks; dexamethasone (DEX) treatment irreversibly impairs septation, and…”
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Tyrosine Phosphorylation Regulates Manganese Superoxide Dismutase (MnSOD) RNA-Binding Protein Activity and MnSOD Protein Expression by Knirsch, Linda, Clerch, Linda Biadasz

“…All cells tested contain a cytosolic protein that binds to a defined region in the 3‘ untranslated region of manganese superoxide dismutase (MnSOD) RNA; both…”
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Perinatal rat lung catalase gene expression: influence of corticosteroid and hyperoxia by Clerch, L B, Iqbal, J, Massaro, D

“…Dexamethasone accelerates the late gestational rise in rat lung catalase activity; neonatal hyperoxia elevates rat lung catalase activity. We studied the…”
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Oxidation-reduction-sensitive binding of lung protein to rat catalase mRNA by CLERCH, L. B, MASSARO, D

“…Air-breathing organisms experience an elevated concentration of oxygen mainly under two conditions. One occurs at birth when the O2 tension in the lung…”
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Rat lung antioxidant enzyme induction by ozone by Rahman, I, Clerch, L B, Massaro, D

“…We exposed rats of different ages (weights approximately 45-300 g) to 0.7 ppm O3 for 1-5 days. At 5 days lungs of O3-exposed rats had higher activity of Cu,Zn…”
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Early divergent lung antioxidant enzyme expression in response to lipopolysaccharide by Clerch, L B, Wright, A, Chung, D J, Massaro, D

“…Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria, interacts with eukaryotic cells, causing changes in gene expression and a…”
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Dinucleotide-binding site of bovine liver catalase mimics a catalase mRNA-binding protein domain by Clerch, L B, Wright, A, Massaro, D

“…Rat lung contains protein that interacts with catalase mRNA to form specific, redox-sensitive RNA-protein complexes. The studies in this report were aimed at…”
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Pertussis toxin alters the concentration and turnover of manganese superoxide dismutase in rat lung by Berkovich, A, Massaro, D, Clerch, L B

“…Treatment of rats with pertussis toxin (PTX) decreases the activity of manganese superoxide dismutase (Mn-SOD) in the lung and results in oxygen toxicity in…”
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Rat lung Cu,Zn superoxide dismutase. Isolation and sequence of a full-length cDNA and studies of enzyme induction by Hass, M A, Iqbal, J, Clerch, L B, Frank, L, Massaro, D

“…The synthesis of Cu,Zn SOD by rat lung increases spontaneously in the fetus in late gestation and during exposure of neonatal and adult rats to greater than…”
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RNA in polysomes is an inhibitor of manganese superoxide dismutase RNA-binding protein activity by Chung, D J, Clerch, L B

“…A redox-sensitive protein in rat lung binds to the 3'-untranslated region (3'-UTR) of manganese superoxide dismutase (Mn-SOD) mRNA; the activity of this Mn-SOD…”
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Sequence of a full-length cDNA for rat lung .beta.-galactoside-binding protein: primary and secondary structure of the lectin by Clerch, Linda B, Whitney, Philip, Hass, Michael, Brew, Keith, Miller, Todd, Werner, Rudolf, Massaro, Donald

“…A full-length cDNA for rat lung beta-galactoside lectin (subunit Mr approximately 14,000, lectin 14K) was cloned and the nucleotide sequence determined. The…”
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Lung manganese superoxide dismutase protein expression increases in the baboon model of bronchopulmonary dysplasia and is regulated at a posttranscriptional level by CLERCH, L. B, WRIGHT, A. E, COALSON, J. J

“…The expression of lung manganese superoxide dismutase (MnSOD) mRNA and protein were examined in a premature baboon model of hyperoxia-induced bronchopulmonary…”
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Rat lung lectin gene expression is regulated developmentally and by dexamethasone by Clerch, L B, Whitney, P, Massaro, D

“…The cell-agglutinating activity of soluble beta-galactoside-binding proteins (lectins) is developmentally regulated in several mammalian organs. Little is…”
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Endotoxin induces rat lung ribonuclease activity by Clerch, Linda B., Wright, Angélique, Massaro, Donald

“…Lipopolysaccharide (endotoxin), a component of Gram-negative bacteria, causes marked alterations in eukaryotic gene expression and cellular physiology. We show…”
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Rat lung lectin synthesis, degradation and activation. Developmental regulation and modulation by dexamethasone by Clerch, L B, Whitney, P L, Massaro, D

“…Soluble lectins are widely distributed cell-agglutinating proteins. Their activity is developmentally regulated in several tissues, including the lung, but…”
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A Region in the 3′ UTR of MnSOD RNA Enhances Translation of a Heterologous RNA by Knirsch, Linda, Clerch, Linda Biadasz

“…The studies reported in this paper were designed to test the hypothesis that a cis element located in the 3′ UTR of manganese superoxide dismutase (MnSOD) RNA,…”
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Molecular mechanisms of antioxidant enzyme expression in lung during exposure to and recovery from hyperoxia by Clerch, L B, Massaro, D, Berkovich, A

“…Manganese superoxide dismutase (MnSOD) activity falls approximately 50% in lung during 48 h of exposure of adult rats to > 95% O2 (L. B. Clerch and D. Massaro…”
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