Search Results - "CLELAND, J. L"

The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation by Cleland, J L, Powell, M F, Shire, S J

“…The biochemical literature has been surveyed to present an overview of the three most common protein degradation pathways: protein aggregation, deamidation,…”
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Single-administration vaccines: controlled-release technology to mimic repeated immunizations by Cleland, Jeffrey L

“…The most effective mechanism for the elimination of disease from society is the use of vaccinations, but these often require repeated administration. However,…”
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Antioxidants for prevention of methionine oxidation in recombinant monoclonal antibody HER2 by Lam, X M, Yang, J Y, Cleland, J L

“…Recombinant humanized monoclonal antibody HER2, rhuMAb HER2, in liquid formulations undergoes oxidation when exposed to intense light and elevated temperatures…”
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Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions by Bam, N B, Cleland, J L, Yang, J, Manning, M C, Carpenter, J F, Kelley, R F, Randolph, T W

“…In the absence of surfactants, recombinant human growth hormone (rhGH) rapidly forms insoluble aggregates during agitation. The nonionic surfactant Tween 20,…”
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Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes by Lam, Xanthe M., Duenas, Eileen T., Daugherty, Ann L., Levin, Nancy, Cleland, Jeffrey L.

“…Recombinant human insulin-like growth factor-I (rhIGF-I) was found to improve glycemic control and enhance insulin sensitivity in patients with a syndrome of…”
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Aggregation of recombinant human interferon gamma: kinetics and structural transitions by Kendrick, B S, Cleland, J L, Lam, X, Nguyen, T, Randolph, T W, Manning, M C, Carpenter, J F

“…Protein aggregation is a complex phenomenon that can occur in vitro and in vivo, usually resulting in the loss of the protein's biological activity. While many…”
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The stabilization and encapsulation of human growth hormone into biodegradable microspheres by JOHNSON, O. L, JAWOROWICZ, W, JONES, A. J. S, PUTNEY, S. D, CLELAND, J. L, BAILEY, L, CHARNIS, M, DUENAS, E, WU, C, SHEPARD, D, MAGIL, S, LAST, T

“…To produce and evaluate sustained-acting formulations of recombinant human growth hormone (rhGH) made by a novel microencapsulation process. The protein was…”
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Polyethylene glycol enhanced refolding of bovine carbonic anhydrase B. Reaction stoichiometry and refolding model by CLELAND, J. L, HEDGEPETH, C, WANG, D. I. C

“…Polyethylene glycol (PEG) inhibited aggregation during refolding of bovine carbonic anhydrase B (CAB) through the formation of a nonassociating…”
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Intracranial delivery of recombinant nerve growth factor : Release kinetics and protein distribution for three delivery systems by SALTZMAN, W. M, MAK, M. W, MAHONEY, M. J, DUENAS, E. T, CLELAND, J. L

“…Three different polymeric delivery systems, composed of either poly(ethylene-co-vinyl acetate) (EVAc) or poly(lactide-co-glycolide) (PLGA), were used to…”
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Factors affecting the in vitro release of recombinant human interferon-gamma (rhIFN-gamma) from PLGA microspheres by Yang, J, Cleland, J L

“…A long-acting depot formulation of recombinant human interferon-gamma (rhIFN-gamma) was achieved by microencapsulation of rhIFN-gamma in polylactic-coglycolic…”
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A slow release formulation of insulin as a treatment for osteoarthritis by Cai, L., Okumu, F.W., Cleland, J.L., Beresini, M., Hogue, D., Lin, Z., Filvaroff, E.H.

“…Objective To examine the potential of insulin, in a sustained delivery system, as a treatment for arthritis. Design The effect of insulin on matrix synthesis,…”
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Stability of protein formulations : investigation of surfactant effects by a novel EPR spectroscopic technique by BAM, N. B, RANDOLPH, T. W, CLELAND, J. L

“…Surfactants are known to stabilize proteins and are often employed as additives in protein formulations. We have developed a method to study the interaction of…”
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Comparison between light induced and chemically induced oxidation of rhVEGF by DUENAS, Eileen T, KECK, Rodney, DEVOS, Abraham, JONES, Andrew J. S, CLELAND, Jeffrey L

“…The primary objective of this study was to compare the effects of light-and chemical-induced oxidation of recombinant human vascular endothelial growth factor…”
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The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) (PLGA) microspheres by CLELAND, J. L, MAC, A, JONES, A. J. S, BOYD, B, YANG, J, DUENAS, E. T, YEUNG, D, BROOKS, D, HSU, C, CHU, H, MUKKU, V

“…The development of a sustained release formulation for recombinant human growth hormone (rhGH) as well as other proteins requires that the protein be stable at…”
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Solvent Evaporation Processes for the Production of Controlled Release Biodegradable Microsphere Formulations for Therapeutics and Vaccines by Cleland, Jeffrey L.

“…Novel drug delivery technologies have now evolved to allow the clinical production of new dosage forms. One new form, biodegradable microspheres, may have…”
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Vascular Endothelial Growth Factor Stimulates Bone Repair by Promoting Angiogenesis and Bone Turnover by Street, John, Bao, Min, deGuzman, Leo, Bunting, Stuart, Peale, Franklin V., Ferrara, Napoleone, Steinmetz, Hope, Hoeffel, John, Cleland, Jeffrey L., Daugherty, Ann, van Bruggen, Nicholas, Redmond, H. Paul, Richard A. D. Carano, Filvaroff, Ellen H.

“…Several growth factors are expressed in distinct temporal and spatial patterns during fracture repair. Of these, vascular endothelial growth factor, VEGF, is…”
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Molten Globule Intermediate of Recombinant Human Growth Hormone: Stabilization with Surfactants by Bam, Narendra B., Cleland, Jeffrey L., Randolph, Theodore W.

“…We demonstrate that a surfactant‐stabilized molten globule intermediate exists for recombinant human growth hormone (rhGH), is very hydrophobic, and tends to…”
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Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres by Yang, T H, Dong, A, Meyer, J, Johnson, O L, Cleland, J L, Carpenter, J F

“…The purpose of this study was to test the utility of infrared (IR) spectroscopy to determine protein secondary structure in biodegradable microspheres…”
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Polyethylene Glycol Enhanced Protein Refolding by Cleland, Jeffrey L, Builder, Stuart E, Swartz, James R, Winkler, Marjorie, Chang, Judy Y, Wang, Daniel I. C

“…Previous studies on the refolding of recombinant bovine carbonic anhydrase B (CAB) indicated that polyethylene glycol (PEG) significantly enhanced the recovery…”
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A large-scale process to produce microencapsulated proteins by HERBERT, P, MURPHY, K, JOHNSON, O, NAN DONG, JAWOROWICZ, W, TRACY, M. A, CLELAND, J. L, PUTNEY, S. D

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