Search Results - "CLAY, M. P"

In Vitro Biotransformation and Identification of Human Cytochrome P450 Isozyme-Dependent Metabolism of Tazofelone by SURAPANENI, S. S, CLAY, M. P, SPANGLE, L. A, PASCHAL, J. W, LINDSTROM, T. D

“…Tazofelone is a new inflammatory bowel disease agent. The biotransformation of tazofelone in human livers and the cytochrome P450 responsible for the…”
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Application of oral bioavailability surrogates in the design of orally active inhibitors of rhinovirus replication by Stratford, Jr, R E, Clay, M P, Heinz, B A, Kuhfeld, M T, Osborne, S J, Phillips, D L, Sweetana, S A, Tebbe, M J, Vasudevan, V, Zornes, L L, Lindstrom, T D

“…Previous studies in rats and humans demonstrated poor oral bioavailability of potent in vitro 2-aminobenzimidazole inhibitors of rhinovirus replication due to…”
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GPU acceleration of a petascale application for turbulent mixing at high Schmidt number using OpenMP 4.5 by Clay, M. P., Buaria, D., Yeung, P. K., Gotoh, T.

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GPU acceleration of a petascale application for turbulent mixing at high Schmidt number using OpenMP 4.5 by Clay, M.P., Buaria, D., Yeung, P.K., Gotoh, T.

“…This paper reports on the successful implementation of a massively parallel GPU-accelerated algorithm for the direct numerical simulation of turbulent mixing…”
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A statistical review of controlled trials of imipramine and placebo in the treatment of depressive illnesses by Rogers, S C, Clay, P M

“…A method of reviewing a series of clinical trials by extracting the basic data in the form of 2 x 2 tables and analysing these by Fisher's two-tailed Exact…”
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A dual communicator and dual grid-resolution algorithm for petascale simulations of turbulent mixing at high Schmidt number by Clay, M.P., Buaria, D., Gotoh, T., Yeung, P.K.

“…A new dual-communicator algorithm with very favorable performance characteristics has been developed for direct numerical simulation (DNS) of turbulent mixing…”
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Implementation of integrated ecosystem assessments in the International Council for the Exploration of the Sea—conceptualizations, practice, and progress by Clay, Patricia M, Ferretti, Johanna, Bailey, Jennifer L, Goti, Leyre, Dankel, Dorothy J, Santurtun, Marina, Fuller, Jessica, Linke, Sebastian, Schmidt, Jörn, Nielsen, Kåre Nolde, Goldsborough, David, Groeneveld, Rolf, Fraga, Ana Rita, Elegbede, Isa, Röckmann, Christine

“…Abstract With increasing activities of multiple sectors in marine spaces, management of marine social–ecological systems requires more holistic approaches…”
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Defining "Fishing Communities": Vulnerability and the Magnuson-Stevens Fishery Conservation and Management Act by Clay, Patricia M., Olson, Julia

“…As populations of many fish species worldwide have declined, the price of fuel has increased, and coastal development has mushroomed, fishing communities have…”
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Building better social impact assessments by Clay, P M, Dolin, E J

“…Fisheries management is people management-influencing people's behavior to promote socially profitable, ecologically sustainable practices. We can better…”
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The long voyage to including sociocultural analysis in NOAA's National Marine Fisheries Service by Abbott-Jamieson, Susan, Clay, Patricia M

“…The United States has managed and analyzed its marine fisheries since 1871, and since 1970 via NOAA's National Marine Fisheries Service (NMFS). As the primary…”
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Stereoselective metabolism of tazofelone, an anti-inflammatory bowel disease agent, in rats and dogs and in human liver microsomes by Clay, Michael P., Hanssen, Brenda R., Surapaneni, Sekhar S., Lindstrom, Terry D.

“…Incubation of (R)‐tazofelone and (S)‐tazofelone in rat, dog, and human liver microsomes demonstrated that the (R)‐tazofelone enantiomer was more rapidly…”
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Toward a model for fisheries social impact assessment by Pollnac, Richard B, Abbott-Jamieson, Susan, Smith, Courtland, Miller, Marc L, Clay, Patricia M, Oles, Bryan

“…This paper presents a model for Fisheries Social Impact Assessment (SIA) that lays the groundwork for development of fisheries-focused, quantitative social…”
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Substituted 3-Imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino- [6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as Highly Selective and Potent Inhibitors of Glycogen Synthase Kinase-3 by Engler, Thomas A, Henry, James R, Malhotra, Sushant, Cunningham, Brian, Furness, Kelly, Brozinick, Joseph, Burkholder, Timothy P, Clay, Michael P, Clayton, Joshua, Diefenbacher, Clive, Hawkins, Eric, Iversen, Philip W, Li, Yihong, Lindstrom, Terry D, Marquart, Angela L, McLean, Johnathan, Mendel, David, Misener, Elizabeth, Briere, Daniel, O'Toole, John C, Porter, Warren J, Queener, Steven, Reel, Jon K, Owens, Rebecca A, Brier, Richard A, Eessalu, Thomas E, Wagner, Jill R, Campbell, Robert M, Vaughn, Renee

“…Glycogen synthase kinase-3 (GSK3) is involved in signaling from the insulin receptor. Inhibitors of GSK3 are expected to effect lowering of plasma glucose…”
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Dipeptides as Effective Prodrugs of the Unnatural Amino Acid (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740), a Selective Group II Metabotropic Glutamate Receptor Agonist by Bueno, Ana Belén, Collado, Iván, de Dios, Alfonso, Domínguez, Carmen, Martín, José Alfredo, Martín, Luisa M, Martínez-Grau, María Angeles, Montero, Carlos, Pedregal, Concepción, Catlow, John, Coffey, D. Scott, Clay, Michael P, Dantzig, Anne H, Lindstrom, Terry, Monn, James A, Jiang, Haiyan, Schoepp, Darryle D, Stratford, Robert E, Tabas, Linda B, Tizzano, Joseph P, Wright, Rebecca A, Herin, Marc F

“…(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (1), also known as LY354740, is a highly potent and selective agonist for group II metabotropic glutamate…”
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Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor by Richardson, Timothy I, Ornstein, Paul L, Briner, Karin, Fisher, Matthew J, Backer, Ryan T, Biggers, C. Kelly, Clay, Michael P, Emmerson, Paul J, Hertel, Larry W, Hsiung, Hansen M, Husain, Saba, Kahl, Steven D, Lee, Jonathan A, Lindstrom, Terry D, Martinelli, Michael J, Mayer, John P, Mullaney, Jeffery T, O'Brien, Thomas P, Pawlak, Joseph M, Revell, Kevin D, Shah, Jikesh, Zgombick, John M, Herr, R. Jason, Melekhov, Alex, Sampson, Peter B, King, Chi-Hsin R

“…The melanocortin receptors have been implicated as potential targets for a number of important therapeutic indications, including inflammation, sexual…”
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Caveat Spectator: Digital Imaging and Data Manipulation by Songcharoen, Somjade J., MD, Bite, Uldis, MD, Clay, Ricky P., MD

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Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats by Lugar, Charles W., Clay, Michael P., Lindstrom, Terry D., Woodson, Andrea L., Smiley, David, Heiman, Mark L., Dodge, Jeffrey A.

“…LY444711 is an orally active ghrelin agonist that binds with good affinity and is a potent activator of the growth hormone secretagogue receptor 1a (GHS-R1a)…”
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Inhibition of granulocyte cAMP-phosphodiesterase by rolipram in vivo is not sufficient to protect the canine myocardium from reperfusion injury by Simpson, P J, Schelm, J A, Smallwood, J K, Clay, M P, Lindstrom, T D

“…The purpose of this study was to determine whether the selective type IV cAMP-phosphodiesterase inhibitor rolipram could reduce the reperfusion injury that…”
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Rapid parallel synthesis applied to the optimization of a series of potent nonpeptide neuropeptide Y-1 receptor antagonists by Siegel, Miles G., Chaney, Michael O., Bruns, Robert F., Clay, Michael P., Schober, Douglas A., Van Abbema, Anne M., Johnson, Douglas W., Cantrell, Buddy E., Hahn, Patric J., Hunden, David C., Gehlert, Donald R., Zarrinmayeh, Hamideh, Ornstein, Paul L., Zimmerman, Dennis M., Koppel, Gary A.

“…This study describes the integrated application of parallel synthesis and computational chemistry to the design of potent nonpeptide antagonists for the…”
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LY503430: Pharmacology, Pharmacokinetics, and Effects in Rodent Models of Parkinson's Disease by O'Neill, Michael J., Murray, Tracey K., Clay, Michael P., Lindstrom, Terry, Yang, Charles R., Nisenbaum, Eric S.

“…ABSTRACT Glutamate is the major excitatory transmitter in the brain. Recent developments in the molecular biology and pharmacology of the…”
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