Evaluation of capillary collection system for HbA1c specimens

Evaluation of capillary collection system for HbA1c specimens

Evaluation of capillary collection system for HbA1c specimens. E M Voss , G S Cembrowski , B L Clasen , M L Spencer , M B Ainslie and B Haig Park Nicollet Medical Center, Minneapolis, MN 55416. Abstract OBJECTIVE--We evaluated the accuracy and stability of a capillary HbA1c collection system for use...

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Published in:Diabetes care Vol. 15; no. 5; pp. 700 - 701
Main Authors: VOSS, E. M, CEMBROWSKI, G. S, CLASEN, B. L, SPENCER, M. L, AINSLIE, M. B, HAIG, B
Format: Journal Article
Language:English
Published: Alexandria, VA American Diabetes Association 01-05-1992
Subjects:
Biological and medical sciences
Blood Specimen Collection - methods
Capillaries
Chromatography, High Pressure Liquid
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Glycated Hemoglobin A - analysis
Humans
Management. Various non-drug treatments. Langerhans islet grafts
Medical sciences
Reference Values
Endocrinopathy
Performance evaluation
Human
Glycemic control
Surveillance
Hemoglobin A1c
Diabetes mellitus
Samplings
HPLC chromatography
Apparatus
Capillary blood
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Summary:Evaluation of capillary collection system for HbA1c specimens. E M Voss , G S Cembrowski , B L Clasen , M L Spencer , M B Ainslie and B Haig Park Nicollet Medical Center, Minneapolis, MN 55416. Abstract OBJECTIVE--We evaluated the accuracy and stability of a capillary HbA1c collection system for use with a high-performance liquid chromatography analyzer. RESEARCH DESIGN AND METHODS--The collection system requires that 5 ul blood is drawn into a calibrated capillary tube, which is then placed into a vial of stabilizing solution and sent for analysis. The study was conducted on simultaneously drawn capillary and venous blood specimens from 47 pediatric diabetes patients. Accuracy was determined by comparing the capillary to the venous HbA1c values. Stability was measured by analyzing 17 capillary specimens over 3 wk. RESULTS--There was excellent agreement between the capillary and venous HbA1c values (capillary 0.959, venous +0.494, R2 = 98.7%). The capillary HbA1c values were 0.2% higher than the venous HbA1c values and decreased gradually over time (0.1% HbA1c/week) when stored at room temperature. CONCLUSIONS--The Bio-Rad (Richmond, CA) collection system is accurate, stable, and simple to use.
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ISSN:0149-5992
1935-5548
DOI:10.2337/diacare.15.5.700