Search Results - "CLARKSON, Bayard D"

Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring KITAY502-3ins Mutation: An In vitro Mutagenesis Screen for Drug Resistance by Guo, Tianhua, Hajdu, Mihai, Agaram, Narasimhan P, Shinoda, Hiroko, Veach, Darren, Clarkson, Bayard D, Maki, Robert G, Singer, Samuel, Dematteo, Ronald P, Besmer, Peter, Antonescu, Cristina R

“…Purpose: Although tyrosine kinase inhibitors have improved survival in advanced gastrointestinal stromal tumor (GIST), complete response is rare and most…”
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Commentary on Sandberg et al., "The In Vivo Chromosome Constitution of Marrow" by Clarkson, Bayard D

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Effect of purified fractions from cell culture supernate of high‐density pre‐B acute lymphoblastic leukemia cells (ALL3) on the growth of ALL3 cells at low density by Patel, Sapan J., Darie, Costel C., Clarkson, Bayard D.

“…The mechanisms underlying the aberrant growth and interactions between cells are not understood very well. The pre‐B acute lymphoblastic leukemia cells…”
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L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition by Antonescu, Cristina R., Busam, Klaus J., Francone, Todd D., Wong, Grace C., Guo, Tianhua, Agaram, Narasimhan P., Besmer, Peter, Jungbluth, Achim, Gimbel, Mark, Chen, Chin‐Tung, Veach, Darren, Clarkson, Bayard D., Paty, Philip B., Weiser, Martin R.

“…Activating mutations in either BRAF or NRAS are seen in a significant number of malignant melanomas, but their incidence appears to be dependent to ultraviolet…”
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The possible roles of B‐cell novel protein‐1 (BCNP1) in cellular signalling pathways and in cancer by Patel, Sapan J., Trivedi, Gaurang L., Darie, Costel C., Clarkson, Bayard D.

“…B‐cell novel protein‐1 (BCNP1) or Family member of 129C (FAM129C) was identified as a B‐cell‐specific plasma‐membrane protein. Bioinformatics analysis…”
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Sorafenib inhibits the imatinib-resistant KITT6701 gatekeeper mutation in gastrointestinal stromal tumor by TIANHUA GUO, AGARAM, Narasimhan P, DEMATTEO, Ronald P, BESMER, Peter, ANTONESCUL, Cristina R, WONG, Grace C, HOM, Glory, D'ADAMO, David, MAKI, Robert G, SCHWARTZ, Gary K, VEACH, Darren, CLARKSON, Bayard D, SINGER, Samuel

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Exosome mediated growth effect on the non-growing pre-B acute lymphoblastic leukemia cells at low starting cell density by Patel, Sapan J, Darie, Costel C, Clarkson, Bayard D

“…Tumors contain heterogeneous cell populations and achieve dominance by functioning as collective systems. The mechanisms underlying the aberrant growth and…”
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Cancer secretomes and their place in supplementing other hallmarks of cancer by Patel, Sapan, Ngounou Wetie, Armand G, Darie, Costel C, Clarkson, Bayard D

“…The secretome includes all macromolecules secreted by cells, in particular conditions at defined times, allowing cell-cell communication. Cancer cell…”
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Defective quorum sensing of acute lymphoblastic leukemic cells: evidence of collective behavior of leukemic populations as semi-autonomous aberrant ecosystems by Patel, Sapan J, Dao, Su, Darie, Costel C, Clarkson, Bayard D

“…Quorum sensing (QS) is a generic term used to describe cell-cell communication and collective decision making by bacterial and social insects to regulate the…”
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Automated Mass Spectrometry–Based Functional Assay for the Routine Analysis of the Secretome by Ngounou Wetie, Armand G., Sokolowska, Izabela, Woods, Alisa G., Wormwood, Kelly L., Dao, Su, Patel, Sapan, Clarkson, Bayard D., Darie, Costel C.

“…The secretome represents the set of proteins secreted into the extracellular space of cells. These proteins have been shown to play a major role in cell-cell…”
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On the Use of Cause-Specific Failure and Conditional Failure Probabilities: Examples from Clinical Oncology Data by Gaynor, Jeffrey J., Feuer, Eric J., Tan, Claire C., Wu, Danny H., Little, Claudia R., Straus, David J., Clarkson, Bayard D., Brennan, Murray F.

“…Nonparametric maximum likelihood estimation of the probability of failing from a particular cause by time t in the presence of other acting causes (i.e., the…”
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Sorafenib Inhibits the Imatinib-Resistant KITT670I Gatekeeper Mutation in Gastrointestinal Stromal Tumor by Guo, Tianhua, Agaram, Narasimhan P, Wong, Grace C, Hom, Glory, D'Adamo, David, Maki, Robert G, Schwartz, Gary K, Veach, Darren, Clarkson, Bayard D, Singer, Samuel, DeMatteo, Ronald P, Besmer, Peter, Antonescu, Cristina R

“…Purpose: Resistance is commonly acquired in patients with metastatic gastrointestinal stromal tumor who are treated with imatinib mesylate, often due to the…”
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Comparison of the cytotoxic effects of merocyanine-540 on leukemic cells and normal human bone marrow by ATZPODIEN, J, GULATI, S. C, CLARKSON, B. D

“…Various chemical compounds have been described to induce photosensitization of tumor cells resulting in cell death. We studied the effect of merocyanine-540…”
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Joseph H. Burchenal: in memoriam (1912-2006)

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Discordant maturation as the primary biological defect in chronic myelogenous leukemia by STRIFE, A, LAMBEK, C, WISNIEWSKI, D, WACHTER, M, GULATI, S. C, CLARKSON, B. D

“…Comparative studies of the in vitro growth characteristics of normal and chronic myelogenous leukemic (CML) progenitor cells have provided further evidence…”
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Effects of recombinant human tumor necrosis factor on highly enriched hematopoietic progenitor cell populations from normal human bone marrow and peripheral blood and bone marrow from patients with chronic myeloid leukemia by WISNIEWSKI, D, STRIFE, A, ATZPODIEN, J, CLARKSON, B. D

“…Previous studies using unseparated normal human bone marrow cells have indicated that recombinant tumor necrosis factor alpha (rTNF-alpha) can inhibit the in…”
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Phase I and II clinical and pharmacological study of 4-demethoxydaunorubicin (idarubicin) in adult patients with acute leukemia by DAGHESTANI, A. N, ARLIN, Z. A, CLARKSON, B. D, YOUNG, C. W, LEYLAND-JONES, B, GEE, T. S, KEMPIN, S. J, MERTELSMANN, R, BUDMAN, D, SCHULMAN, P, BARATZ, R, WILLIAMS, L

“…Fifty-two adults treated previously with either acute leukemia (43 patients) or blastic-phase chronic myelogenous leukemia (nine patients) received…”
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Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring KIT AY502-3ins Mutation: An In vitro Mutagenesis Screen for Drug Resistance by Guo, Tianhua, Hajdu, Mihai, Agaram, Narasimhan P., Shinoda, Hiroko, Veach, Darren, Clarkson, Bayard D., Maki, Robert G., Singer, Samuel, DeMatteo, Ronald P., Besmer, Peter, Antonescu, Cristina R.

“…Purpose: Although tyrosine kinase inhibitors have improved survival in advanced gastrointestinal stromal tumor (GIST), complete response is rare and most…”
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The elusive goal: presidential address by Clarkson, B D

“…The advances in treatment of cancer which have taken place during the last 25 years are quite remarkable considering that therapists have had at their disposal…”
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Unfractionated human marrow cell cryopreservation using dimethylsulfoxide and hydroxyethyl starch by Stiff, P J, Murgo, A J, Zaroulis, C G, DeRisi, M F, Clarkson, B D

“…Unfractionated bone marrow (BM) cells were cryopreserved in 1- to 2-ml aliquots using a mixture containing both 5% dimethylsulfoxide (DMSO) and 6% hydroxyethyl…”
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