Search Results - "CLARKE MILLER, M"

Hydration Is a Major Determinant of the G-Quadruplex Stability and Conformation of the Human Telomere 3′ Sequence of d(AG3(TTAG3)3) by Miller, M. Clarke, Buscaglia, Robert, Chaires, Jonathan B, Lane, Andrew N, Trent, John O

“…The factors that determine the conformation and stability of G-quadruplex forming sequences remain poorly understood. Here we demonstrate the influence of…”
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Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence by Dailey, Magdalena M, Miller, M. Clarke, Bates, Paula J, Lane, Andrew N, Trent, John O

“…The remarkable structural polymorphism of quadruplex-forming sequences has been a considerable impediment in the elucidation of quadruplex folds. Sequence…”
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IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment by Gaddipati, Subhash, Lu, Qingxian, Kasetti, Ramesh Babu, Miller, M Clarke, Lu, Qingjun, Trent, John O, Kaplan, Henry J, Li, Qiutang

“…The inhibition of NF-κB by genetic deletion or pharmacological inhibition of IKK2 significantly reduces laser-induced choroid neovascularization (CNV). To…”
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Eubacterial SpoVG homologs constitute a new family of site-specific DNA-binding proteins by Jutras, Brandon L, Chenail, Alicia M, Rowland, Christi L, Carroll, Dustin, Miller, M Clarke, Bykowski, Tomasz, Stevenson, Brian

“…A site-specific DNA-binding protein was purified from Borrelia burgdorferi cytoplasmic extracts, and determined to be a member of the highly conserved SpoVG…”
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Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement by Stevenson, Brian, Choy, Henry A, Pinne, Marija, Rotondi, Matthew L, Miller, M Clarke, Demoll, Edward, Kraiczy, Peter, Cooley, Anne E, Creamer, Trevor P, Suchard, Marc A, Brissette, Catherine A, Verma, Ashutosh, Haake, David A

“…The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues…”
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Trichoplusia ni (Lepidoptera: Noctuidae) Qualitative and Quantitative Sequestration of Host Plant Carotenoids by Nguyen, Kieu-Oanh, Al-Rashid, Sayma, Miller, M. Clarke, Diggs, J. Tom, Lampert, Evan C

“…Carotenoids are fundamental precursors for hormones and antioxidants, and insects must acquire carotenoids from their diet. Previous research has shown that…”
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Solution structure of the RBD1,2 domains from human nucleolin by Arumugam, Sengodagounder, Clarke Miller, M, Maliekal, James, Bates, Paula J, Trent, John O, Lane, Andrew N

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Borrelia burgdorferi EbfC defines a newly-identified, widespread family of bacterial DNA-binding proteins by Riley, Sean P, Bykowski, Tomasz, Cooley, Anne E, Burns, Logan H, Babb, Kelly, Brissette, Catherine A, Bowman, Amy, Rotondi, Matthew, Miller, M. Clarke, DeMoll, Edward, Lim, Kap, Fried, Michael G, Stevenson, Brian

“…The Lyme disease spirochete, Borrelia burgdorferi, encodes a novel type of DNA-binding protein named EbfC. Orthologs of EbfC are encoded by a wide range of…”
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Borrelia burgdorferi EbfC, a Novel, Chromosomally Encoded Protein, Binds Specific DNA Sequences Adjacent to erp Loci on the Spirochete's Resident cp32 Prophages by BABB, Kelly, BYKOWSKI, Tomasz, RILEY, Sean P, CLARKE MILLER, M, DEMOLL, Edward, STEVENSON, Brian

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Release kinetics of paclitaxel and cisplatin from two and three layered gold nanoparticles by England, Christopher G., Miller, M. Clarke, Kuttan, Ashani, Trent, John O., Frieboes, Hermann B.

“…[Display omitted] •The drug release of Hydrophilic and hydrophobic was assessed from layered Au nanoparticles.•Layers were – thiol/phosphatidylcholine, or both…”
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The Yersinia pestis siderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in mice by Bobrov, Alexander G., Kirillina, Olga, Fetherston, Jacqueline D., Miller, M. Clarke, Burlison, Joseph A., Perry, Robert D.

“…Summary Bacterial pathogens must overcome host sequestration of zinc (Zn2+), an essential micronutrient, during the infectious disease process. While the…”
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Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection by Buscaglia, Robert, Miller, M Clarke, Dean, William L, Gray, Robert D, Lane, Andrew N, Trent, John O, Chaires, Jonathan B

“…Polyethylene glycols (PEGs) are widely used to perturb the conformations of nucleic acids, including G-quadruplexes. The mechanism by which PEG alters…”
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DNA-binding by Haemophilus influenzae and Escherichia coli YbaB, members of a widely-distributed bacterial protein family by Cooley, Anne E, Riley, Sean P, Kral, Keith, Miller, M Clarke, DeMoll, Edward, Fried, Michael G, Stevenson, Brian

“…Genes orthologous to the ybaB loci of Escherichia coli and Haemophilus influenzae are widely distributed among eubacteria. Several years ago, the…”
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Not all G-quadruplexes are created equally: an investigation of the structural polymorphism of the c-Myc G-quadruplex-forming sequence and its interaction with the porphyrin TMPyP4 by Le, Huy T, Miller, M Clarke, Buscaglia, Robert, Dean, William L, Holt, Patrick A, Chaires, Jonathan B, Trent, John O

“…G-quadruplexes, DNA tertiary structures highly localized to functionally important sites within the human genome, have emerged as important new drug targets…”
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Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice by Bobrov, Alexander G, Kirillina, Olga, Fosso, Marina Y, Fetherston, Jacqueline D, Miller, M Clarke, VanCleave, Tiva T, Burlison, Joseph A, Arnold, William K, Lawrenz, Matthew B, Garneau-Tsodikova, Sylvie, Perry, Robert D

“…A number of bacterial pathogens require the ZnuABC Zinc (Zn ) transporter and/or a second Zn transport system to overcome Zn sequestration by mammalian hosts…”
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Bpur, the Lyme disease spirochete's PUR domain protein: identification as a transcriptional modulator and characterization of nucleic acid interactions by Jutras, Brandon L, Chenail, Alicia M, Carroll, Dustin W, Miller, M Clarke, Zhu, Haining, Bowman, Amy, Stevenson, Brian

“…The PUR domain is a nucleic acid-binding motif found in critical regulatory proteins of higher eukaryotes and in certain species of bacteria. During…”
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Polymorphism and resolution of oncogene promoter quadruplex-forming sequences by Miller, M Clarke, Le, Huy T, Dean, William L, Holt, Patrick A, Chaires, Jonathan B, Trent, John O

“…We report the separation of several quadruplex species formed by ten promoter sequences by Size Exclusion Chromatography (SEC). Modification at the 5' or 3'…”
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Reduced synthesis of the Ybt siderophore or production of aberrant Ybt-like molecules activates transcription of yersiniabactin genes in Yersinia pestis by Miller, M Clarke, Fetherston, Jacqueline D, Pickett, Carol L, Bobrov, Alexander G, Weaver, Robert H, DeMoll, Edward, Perry, Robert D

“…Synthesis of the siderophore yersiniabactin (Ybt) proceeds by a mixed nonribosomal peptide synthetase/polyketide synthase mechanism. Transcription of ybt genes…”
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Structure-based drug design: From nucleic acid to membrane protein targets by Dailey, Magdalena M., Hait, Chayanendu, Holt, Patrick A., Maguire, Jon M., Meier, Jason B., Miller, M. Clarke, Petraccone, Luigi, Trent, John O.

“…The in silico methods for drug discovery are becoming increasingly powerful and useful. That, in combination with increasing computer processor power, in our…”
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Separation of Quadruplex Polymorphism in DNA Sequences by Reversed-Phase Chromatography by Miller, M Clarke, Ohrenberg, Carl J, Kuttan, Ashani, Trent, John O

“…This unit describes a method for the separation of a mixture of quadruplex conformations formed from the same parent sequence via reversed-phase chromatography…”
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