Search Results - "CLARKE, Stuart C"

Secondary Bacterial Infections Associated with Influenza Pandemics by Morris, Denise E, Cleary, David W, Clarke, Stuart C

“…Lower and upper respiratory infections are the fourth highest cause of global mortality (Lozano et al., 2012). Epidemic and pandemic outbreaks of respiratory…”
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Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations by Mayhew, David, Devos, Nathalie, Lambert, Christophe, Brown, James R, Clarke, Stuart C, Kim, Viktoriya L, Magid-Slav, Michal, Miller, Bruce E, Ostridge, Kristoffer K, Patel, Ruchi, Sathe, Ganesh, Simola, Daniel F, Staples, Karl J, Sung, Ruby, Tal-Singer, Ruth, Tuck, Andrew C, Van Horn, Stephanie, Weynants, Vincent, Williams, Nicholas P, Devaster, Jeanne-Marie, Wilkinson, Tom M A

“…Alterations in the composition of the lung microbiome associated with adverse clinical outcomes, known as dysbiosis, have been implicated with disease severity…”
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Low-Dose Nitric Oxide as Targeted Anti-biofilm Adjunctive Therapy to Treat Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis by Howlin, Robert P., Cathie, Katrina, Hall-Stoodley, Luanne, Cornelius, Victoria, Duignan, Caroline, Allan, Raymond N., Fernandez, Bernadette O., Barraud, Nicolas, Bruce, Ken D., Jefferies, Johanna, Kelso, Michael, Kjelleberg, Staffan, Rice, Scott A., Rogers, Geraint B., Pink, Sandra, Smith, Caroline, Sukhtankar, Priya S., Salib, Rami, Legg, Julian, Carroll, Mary, Daniels, Thomas, Feelisch, Martin, Stoodley, Paul, Clarke, Stuart C., Connett, Gary, Faust, Saul N., Webb, Jeremy S.

“…Despite aggressive antibiotic therapy, bronchopulmonary colonization by Pseudomonas aeruginosa causes persistent morbidity and mortality in cystic fibrosis…”
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Changes in serotype prevalence of Streptococcus pneumoniae in Southampton, UK between 2006 and 2018 by Cleary, David W., Jones, Jessica, Gladstone, Rebecca A., Osman, Karen L., Devine, Vanessa T., Jefferies, Johanna M., Bentley, Stephen D., Faust, Saul N., Clarke, Stuart C.

“…Streptococcus pneumoniae continues to cause significant disease burden. Whilst pneumococcal conjugate vaccines (PCV) have substantially reduced this burden,…”
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Respiratory carriage of hypervirulent Klebsiella pneumoniae by indigenous populations of Malaysia by Das, Souradeep, Pandey, Anish K, Morris, Denise E, Anderson, Rebecca, Lim, Victor, Wie, Chong Chun, Yap, Ivan Kok Seng, Alattraqchi, Ahmed Ghazi, Simin, Hafis, Abdullah, Ramle, Yeo, Chew Chieng, Clarke, Stuart C, Cleary, David W

“…Klebsiella pneumoniae is a Gram-negative Enterobacteriaceae that is classified by the World Health Organisation (WHO) as a Priority One ESKAPE pathogen. South…”
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Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD by Staples, Karl J, Taylor, Stephen, Thomas, Steve, Leung, Stephanie, Cox, Karen, Pascal, Thierry G, Ostridge, Kristoffer, Welch, Lindsay, Tuck, Andrew C, Clarke, Stuart C, Gorringe, Andrew, Wilkinson, Tom M A

“…Non-typeable Haemophilus influenzae (NTHi) is a key pathogen in COPD, being associated with airway inflammation and risk of exacerbation. Why some patients are…”
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Risk factor profiles and clinical outcomes for children and adults with pneumococcal infections in Singapore: A need to expand vaccination policy? by Martinez-Vega, Rosario, Jauneikaite, Elita, Thoon, Koh Cheng, Chua, Hui Ying, Huishi Chua, Amanda, Khong, Wei Xin, Tan, Ban Hock, Low Guek Hong, Jenny, Venkatachalam, Indumathi, Anantharajah Tambyah, Paul, Hibberd, Martin L, Clarke, Stuart C, Ng, Oon Tek

“…Invasive pneumococcal infection is a major cause of morbidity and mortality worldwide despite the availability of pneumococcal vaccines. The aim of this study…”
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Multicentre case-control study of pneumococcal infections among children with pneumonia in Peninsular Malaysia (MY-Pneumo): a study protocol by Ramzi, Nurul Hanis, Hoong, Andrew Tan Chun, Johari, Nur Alia, Nathan, Anna Marie, Teh, Cindy Shuan Ju, Sulaiman, Norhayati Aida, Ilias, Mohamad Ikram, Deris, Zakuan Zainy, Hazlan, Siti Nur Haidar, Nasir, Nur Syafiqah Mohamad, Bakar, Asrar Abu, Helmi, Muhd Alwi Muhd, Juhari, Wan Khairunnisa Wan, Kamarudin, Norhidayah, Chong, Chun Wie, Cleary, David W, Clarke, Stuart C, Sulaiman, Lokman Hakim

“…S. pneumoniae (SPN) is the most common cause of pneumonia. The disease can be effectively prevented through immunisation. Since December 2020, the Malaysian…”
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Impact of Meningococcal Serogroup C Conjugate Vaccines on Carriage and Herd Immunity by Maiden, Martin C. J., Ibarz-Pavón, Ana Belén, Urwin, Rachel, Gray, Stephen J., Andrews, Nicholas J., Clarke, Stuart C., Walker, A. Mark, Evans, Meirion R., Kroll, J. Simon, Neal, Keith R., Ala'Aldeen, Dlawer A. A., Crook, Derrick W., Cann, Kathryn, Harrison, Sarah, Cunningham, Richard, Baxter, David, Kaczmarski, Edward, MacLennan, Jenny, Cameron, J. Claire, Stuart, James M.

“…Background. In 1999, meningococcal serogroup C conjugate (MCC) vaccines were introduced in the United Kingdom for those under 19 years of age. The impact of…”
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Pronounced metabolic changes in adaptation to biofilm growth by Streptococcus pneumoniae by Allan, Raymond N, Skipp, Paul, Jefferies, Johanna, Clarke, Stuart C, Faust, Saul N, Hall-Stoodley, Luanne, Webb, Jeremy

“…Streptococcus pneumoniae accounts for a significant global burden of morbidity and mortality and biofilm development is increasingly recognised as important…”
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Acinetobacter spp. Infections in Malaysia: A Review of Antimicrobial Resistance Trends, Mechanisms and Epidemiology by Mohd Rani, Farahiyah, A Rahman, Nor Iza, Ismail, Salwani, Alattraqchi, Ahmed Ghazi, Cleary, David W, Clarke, Stuart C, Yeo, Chew Chieng

“…spp. are important nosocomial pathogens, in particular the - complex, which have become a global public health threat due to increasing resistance to…”
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Investigation of upper respiratory carriage of bacterial pathogens among university students in Kampar, Malaysia by Ong, Hing Huat, Toh, Wai Keat, Thong, Li Ying, Phoon, Lee Quen, Clarke, Stuart C, Cheah, Eddy Seong Guan

“…The carriage of bacterial pathogens in the human upper respiratory tract (URT) is associated with a risk of invasive respiratory tract infections, but the…”
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Meningococcal carriage in adolescents in the United Kingdom to inform timing of an adolescent vaccination strategy by Jeppesen, Catherine A, Snape, Matthew D, Robinson, Hannah, Gossger, Nicoletta, John, Tessa M, Voysey, Merryn, Ladhani, Shamez, Okike, Ifeanyichukwu O, Oeser, Clarissa, Kent, Alison, Oliver, Jennifer, Taylor, Pippa, Morales-Aza, Begonia, Clarke, Stuart C, Casey, Michelle, Martins, Filipa, Kitchin, Nicholas R.E, Anderson, Annaliesa S, Jones, Hal, Jansen, Kathrin U, Eiden, Joseph, Pedneault, Louise, Heath, Paul T, Finn, Adam, Faust, Saul N, Pollard, Andrew J

“…Summary Objectives Recent development of serogroup B meningococcal (MenB) vaccines highlights the importance of pharyngeal carriage data, particularly in…”
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Non-pharmaceutical interventions for COVID-19 transiently reduced pneumococcal and Haemophilus influenzae carriage in a cross-sectional pediatric cohort in Southampton, UK by Cleary, David W, Campling, James, Lahuerta, Maria, Hayford, Kyla, Southern, Jo, Gessner, Bradford D, Lo, Stephanie W, Bentley, Stephen D, Faust, Saul N, Clarke, Stuart C

“…The Southampton pneumococcal carriage study of children under 5 years old continued during the coronavirus disease 2019 (COVID-19) pandemic. Here, we present…”
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Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in COPD by Ostridge, Kristoffer, Williams, Nicholas P, Kim, Viktoriya, Harden, Stephen, Bourne, Simon, Clarke, Stuart C, Aris, Emmanuel, Mesia-Vela, Sonia, Devaster, Jeanne-Marie, Tuck, Andrew, Williams, Anthony, Wootton, Stephen, Staples, Karl J, Wilkinson, Tom M A

“…COPD is a complex, heterogeneous disease characterised by progressive development of airflow limitation. Spirometry provides little information about key…”
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Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD by Williams, Nicholas P, Ostridge, Kristoffer, Devaster, Jeanne-Marie, Kim, Viktoriya, Coombs, Ngaire A, Bourne, Simon, Clarke, Stuart C, Harden, Stephen, Abbas, Ausami, Aris, Emmanuel, Lambert, Christophe, Tuck, Andrew, Williams, Anthony, Wootton, Stephen, Staples, Karl J, Wilkinson, Tom M A

“…COPD patients have increased risk of developing pneumonia, which is associated with poor outcomes. It can be symptomatically indistinguishable from…”
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Intracellular residency of Staphylococcus aureus within mast cells in nasal polyps: A novel observation by Hayes, Stephen M., MRCS, Howlin, Robert, PhD, Johnston, David A., PhD, Webb, Jeremy S., PhD, Clarke, Stuart C., FRCPath, FFPH, Stoodley, Paul, PhD, Harries, Philip G., FRCS (ORL-HNS), Wilson, Susan J., PhD, Pender, Sylvia L.F., PhD, Faust, Saul N., PhD, FRCPCH, Hall-Stoodley, Luanne, PhD, Salib, Rami J., PhD, FRCS (ORL-HNS)

“…MCs appear to play an important role in promoting innate immunity against microbial pathogens.8 Through activation of CD8+ T cells, MCs possess the ability to…”
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Complete Genome Sequencing of Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 Unveils a Large Multidrug-Resistant Plasmid Encoding the NDM-1 and OXA-58 Carbapenemases by Alattraqchi, Ahmed Ghazi, Mohd Rani, Farahiyah, A Rahman, Nor Iza, Ismail, Salwani, Cleary, David W, Clarke, Stuart C, Yeo, Chew Chieng

“…Carbapenem-resistant spp. are considered priority drug-resistant human-pathogenic bacteria. The genomes of two carbapenem-resistant spp. clinical isolates…”
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Global funding trends for malaria research in sub-Saharan Africa: a systematic analysis by Head, Michael G, Goss, Sian, Gelister, Yann, Alegana, Victor, Brown, Rebecca J, Clarke, Stuart C, Fitchett, Joseph R A, Atun, Rifat, Scott, J Anthony G, Newell, Marie-Louise, Padmadas, Sabu S, Tatem, Andrew J

“…Total domestic and international funding for malaria is inadequate to achieve WHO global targets in burden reduction by 2030. We describe the trends of…”
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A brief history of and future prospects for pneumococcal vaccination in Malaysia by Lister, Alex J. J., Dombay, Evelin, Cleary, David W., Sulaiman, Lokman H., Clarke, Stuart C.

“…Pneumococcal pneumonia remains a significant global public health issue. Malaysia has recently added the 10 valent pneumococcal conjugate vaccine to its…”
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