Search Results - "CLARKE, P. A"

Personalized Cancer Medicine: Molecular Diagnostics, Predictive biomarkers, and Drug Resistance by Gonzalez de Castro, D, Clarke, P A, Al-Lazikani, B, Workman, P

“…The progressive elucidation of the molecular pathogenesis of cancer has fueled the rational development of targeted drugs for patient populations stratified by…”
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Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors by Shuttleworth, S J, Silva, F A, Cecil, A R L, Tomassi, C D, Hill, T J, Raynaud, F I, Clarke, P A, Workman, P

“…The phosphoinositide 3-kinases (PI3Ks) constitute an important family of lipid kinase enzymes that control a range of cellular processes through their…”
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Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors by Smith, J R, Clarke, P A, de Billy, E, Workman, P

“…The cochaperone CDC37 promotes the association of HSP90 with the protein kinase subset of client proteins to maintain their stability and signalling functions…”
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Kirsten ras Mutations in Patients With Colorectal Cancer: the Multicenter “RASCAL” Study by Andreyev, H. Jervoise N., Norman, Andrew R., Clarke, Paul A., Cunningham, David, Oates, Jacqueline R.

“…Background: Kirsten ras (Ki-ras) gene mutations occur early in the progression of colorectal adenoma to carcinoma. The aim of this collaborative study was to…”
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Evaluation of the LMA Supreme™ in 100 non‐paralysed patients by Cook, T. M., Gatward, J. J., Handel, J., Hardy, R., Thompson, C., Srivastava, R, Clarke, P. A.

“…Summary We studied the LMA Supreme™ in 100 elective, anaesthetised, healthy patients assessing: ease of use, airway quality, anatomical and functional…”
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BCL-2 antisense therapy in patients with non-Hodgkin lymphoma by Webb, A, Cunningham, D, Cotter, F, Clarke, P A, di Stefano, F, Ross, P, Corbo, M, Dziewanowska, Z

“…Overexpression of BCL-2 is common in non-Hodgkin lymphoma and leads to resistance to programmed cell death (apoptosis) and promotes tumorigenesis. Antisense…”
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Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone by CLARKE, P. A, HOSTEIN, I, BANERJI, U, DI STEFANO, F, MALONEY, A, WALTON, M, JUDSON, I, WORKMAN, P

“…A number of molecular therapeutic agents, derived from exploiting our knowledge of the oncogenic pathways that are frequently deregulated in cancer, are now…”
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Phase I Clinical and Pharmacokinetic Study of Bcl-2 Antisense Oligonucleotide Therapy in Patients With Non-Hodgkin’s Lymphoma by WATERS, J. S, WEBB, A, CUNNINGHAM, D, CLARKE, P. A, RAYNAUD, F, DI STEFANO, F, COTTER, F. E

“…To evaluate the pharmacokinetics and toxicity of an antisense oligonucleotide targeting bcl-2 in patients with non-Hodgkin's lymphoma (NHL) and to determine…”
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De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis by EI-ZAATARI, M, TOBIAS, A, GRABOWSKA, A. M, KUMARI, R, SCOTTING, P. J, KAYE, P, ATHERTON, J, CLARKE, P. A, POWE, D. G, WATSON, S. A

“…This study investigated sonic hedgehog (Shh) signalling in gastric metaplasia in the insulin-gastrin (InsGas) hypergastrinaemic mouse +/- Helicobacter felis…”
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Apoptosis is associated with triacylglycerol accumulation in Jurkat T-cells by AL-SAFFAR, N. M. S, TITLEY, J. C, ROBERTSON, D, CLARKE, P. A, JACKSON, L. E, LEACH, M. O, RONEN, S. M

“…Magnetic resonance spectroscopy is increasingly used as a non-invasive method to investigate apoptosis. Apoptosis was induced in Jurkat T-cells by Fas mAb…”
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Gelatinase (MMP-2 and -9) expression in gastrointestinal malignancy by PARSONS, S. L, WATSON, S. A, COLLINS, H. M, GRIFFIN, N. R, CLARKE, P. A, STEELE, R. J. C

“…The aim of the study was to investigate expression of the active and inactive gelatinases (MMP-2 and -9) in colorectal neoplasia and gastric cancer compared…”
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Surgical delivery of drug releasing poly(lactic-co-glycolic acid)/poly(ethylene glycol) paste with in vivo effects against glioblastoma by Smith, S J, Rahman, C V, Clarke, P A, Ritchie, A A, Gould, T W, Ward, J H, Shakesheff, K M, Grundy, R G, Rahman, R

“…The median survival of patients with glioblastoma multiforme (astrocytoma grade 4) remains less than 18 months despite radical surgery, radiotherapy and…”
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Expression of gastrin in developing gastric adenocarcinoma by Henwood, M., Clarke, P. A., Smith, A. M., Watson, S. A.

“…Background: A stepwise progression through premalignant stages has been identified for the intestinal type of gastric carcinoma. As gastrin has been identified…”
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Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence by WATSON, S. A, MORRIS, T. M, MCWILLIAMS, D. F, HARRIS, J, EVANS, S, SMITH, A, CLARKE, P. A

“…The role of hyper-gastrinaemia in the incidence of colonic cancer remains to be clarified. The aim of this study was to determine whether cholecystokinin-2…”
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A neutron diffraction study of load partitioning in continuous Ti/SiC composites by Withers, P.J., Clarke, A.P.

“…Neutron diffraction measurements are described of the internal strain response of Ti–6Al–4V/35 vol.% SiC continuous fibre composites to loading axial and…”
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Characterisation of molecular events following cisplatin treatment of two curable ovarian cancer models: contrasting role for p53 induction and apoptosis in vivo by CLARKE, P. A, PESTELL, K. E, DI STEFANO, F, WORKMAN, P, WALTON, M. I

“…The detailed molecular basis and determinants of in vivo tumour sensitivity to conventional anticancer agents remain unclear. We examined the cellular and…”
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Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control by Pawlyn, C, Bright, M D, Buros, A F, Stein, C K, Walters, Z, Aronson, L I, Mirabella, F, Jones, J R, Kaiser, M F, Walker, B A, Jackson, G H, Clarke, P A, Bergsagel, P L, Workman, P, Chesi, M, Morgan, G J, Davies, F E

“…Myeloma is heterogeneous at the molecular level with subgroups of patients characterised by features of epigenetic dysregulation. Outcomes for myeloma patients…”
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Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins by Smith, J R, de Billy, E, Hobbs, S, Powers, M, Prodromou, C, Pearl, L, Clarke, P A, Workman, P

“…The HSP90 molecular chaperone plays a key role in the maturation, stability and activation of its clients, including many oncogenic proteins. Kinases are a…”
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Transdisciplinary synthesis for ecosystem science, policy and management: The Australian experience by Lynch, A.J.J., Thackway, R., Specht, A., Beggs, P.J., Brisbane, S., Burns, E.L., Byrne, M., Capon, S.J., Casanova, M.T., Clarke, P.A., Davies, J.M., Dovers, S., Dwyer, R.G., Ens, E., Fisher, D.O., Flanigan, M., Garnier, E., Guru, S.M., Kilminster, K., Locke, J., Mac Nally, R., McMahon, K.M., Mitchell, P.J., Pierson, J.C., Rodgers, E.M., Russell-Smith, J., Udy, J., Waycott, M.

“…Mitigating the environmental effects of global population growth, climatic change and increasing socio-ecological complexity is a daunting challenge. To tackle…”
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Intergranular strains in Inconel-600 and the impact on interpreting stress fields in bent steam-generator tubing by Holden, T.M., Holt, R.A., Clarke, A.P.

“…Neutron diffraction measurements are reported of the intergranular (type 2) strains developed in situ under an applied stress in Inconel-600. The magnitudes…”
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