Search Results - "CLARKE, Ian D"

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity by Meyer, Mona, Reimand, Jüri, Lan, Xiaoyang, Head, Renee, Zhu, Xueming, Kushida, Michelle, Bayani, Jane, Pressey, Jessica C., Lionel, Anath C., Clarke, Ian D., Cusimano, Michael, Squire, Jeremy A., Scherer, Stephen W., Bernstein, Mark, Woodin, Melanie A., Bader, Gary D., Dirks, Peter B.

“…Glioblastoma (GBM) is a cancer comprised of morphologically, genetically, and phenotypically diverse cells. However, an understanding of the functional…”
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Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells by Dolma, Sonam, Selvadurai, Hayden J., Lan, Xiaoyang, Lee, Lilian, Kushida, Michelle, Voisin, Veronique, Whetstone, Heather, So, Milly, Aviv, Tzvi, Park, Nicole, Zhu, Xueming, Xu, ChangJiang, Head, Renee, Rowland, Katherine J., Bernstein, Mark, Clarke, Ian D., Bader, Gary, Harrington, Lea, Brumell, John H., Tyers, Mike, Dirks, Peter B.

“…Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals on GBM growth is largely unexplored. We interrogated 680…”
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ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells by Park, Nicole I., Guilhamon, Paul, Desai, Kinjal, McAdam, Rochelle F., Langille, Ellen, O’Connor, Madlen, Lan, Xiaoyang, Whetstone, Heather, Coutinho, Fiona J., Vanner, Robert J., Ling, Erick, Prinos, Panagiotis, Lee, Lilian, Selvadurai, Hayden, Atwal, Gurnit, Kushida, Michelle, Clarke, Ian D., Voisin, Veronique, Cusimano, Michael D., Bernstein, Mark, Das, Sunit, Bader, Gary, Arrowsmith, Cheryl H., Angers, Stephane, Huang, Xi, Lupien, Mathieu, Dirks, Peter B.

“…Glioblastomas exhibit a hierarchical cellular organization, suggesting that they are driven by neoplastic stem cells that retain partial yet abnormal…”
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Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma by Vanner, Robert J., Remke, Marc, Gallo, Marco, Selvadurai, Hayden J., Coutinho, Fiona, Lee, Lilian, Kushida, Michelle, Head, Renee, Morrissy, Sorana, Zhu, Xueming, Aviv, Tzvi, Voisin, Veronique, Clarke, Ian D., Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M., Marra, Marco A., Malkin, David, Northcott, Paul A., Kool, Marcel, Pfister, Stefan M., Bader, Gary, Hochedlinger, Konrad, Korshunov, Andrey, Taylor, Michael D., Dirks, Peter B.

“…Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2+ cells propagate sonic…”
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Identification of human brain tumour initiating cells by Dirks, Peter B, Singh, Sheila K, Hawkins, Cynthia, Clarke, Ian D, Squire, Jeremy A, Bayani, Jane, Hide, Takuichiro, Henkelman, R. Mark, Cusimano, Michael D

“…The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with stem cell properties…”
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A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells by GALLO, Marco, HO, Jenny, COUTINHO, Fiona J, VANNER, Robert, LEE, Lilian, HEAD, Renee, LING, Erick K. M, CLARKE, Ian D, DIRKS, Peter B

“…Glioblastoma growth is driven by cancer cells that have stem cell properties, but molecular determinants of their tumorigenic behavior are poorly defined. In…”
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Multipotent CD15+ Cancer Stem Cells in Patched-1-Deficient Mouse Medulloblastoma by WARD, Ryan J, LEE, Lilian, HUI, Chi-Chung, DIRKS, Peter B, GRAHAM, Kevin, SATKUNENDRAN, Thevagi, YOSHIKAWA, Koichi, LING, Erick, HARPER, Lauren, AUSTIN, Ryan, NIEUWENHUIS, Erica, CLARKE, Ian D

“…Subpopulations of tumorigenic cells have been identified in many human tumors, although these cells may not be very rare in some types of cancer. Here, we…”
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ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells by Park, Nicole I., Guilhamon, Paul, Desai, Kinjal, McAdam, Rochelle F., Langille, Ellen, O’Connor, Madlen, Lan, Xiaoyang, Whetstone, Heather, Coutinho, Fiona J., Vanner, Robert J., Ling, Erick, Prinos, Panagiotis, Lee, Lilian, Selvadurai, Hayden, Atwal, Gurnit, Kushida, Michelle, Clarke, Ian D., Voisin, Veronique, Cusimano, Michael D., Bernstein, Mark, Das, Sunit, Bader, Gary, Arrowsmith, Cheryl H., Angers, Stephane, Huang, Xi, Lupien, Mathieu, Dirks, Peter B.

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ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents by Agnihotri, Sameer, Burrell, Kelly, Buczkowicz, Pawel, Remke, Marc, Golbourn, Brian, Chornenkyy, Yevgen, Gajadhar, Aaron, Fernandez, Nestor A, Clarke, Ian D, Barszczyk, Mark S, Pajovic, Sanja, Ternamian, Christian, Head, Renee, Sabha, Nesrin, Sobol, Robert W, Taylor, Michael D, Rutka, James T, Jones, Chris, Dirks, Peter B, Zadeh, Gelareh, Hawkins, Cynthia

“…Alkylating agents are a first-line therapy for the treatment of several aggressive cancers, including pediatric glioblastoma, a lethal tumor in children…”
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A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas by Agnihotri, Sameer, Wolf, Amparo, Munoz, Diana M, Smith, Christopher J, Gajadhar, Aaron, Restrepo, Andres, Clarke, Ian D, Fuller, Gregory N, Kesari, Santosh, Dirks, Peter B, McGlade, C Jane, Stanford, William L, Aldape, Kenneth, Mischel, Paul S, Hawkins, Cynthia, Guha, Abhijit

“…Glioblastoma Multiforme (GBM), the most common and lethal primary human brain tumor, exhibits multiple molecular aberrations. We report that loss of the…”
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MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy by Rastegar, Mojgan, Hotta, Akitsu, Pasceri, Peter, Makarem, Maisam, Cheung, Aaron Y L, Elliott, Shauna, Park, Katya J, Adachi, Megumi, Jones, Frederick S, Clarke, Ian D, Dirks, Peter, Ellis, James

“…Rett Syndrome (RTT) is an Autism Spectrum Disorder and the leading cause of mental retardation in females. RTT is caused by mutations in the Methyl CpG-Binding…”
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Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens by Pollard, Steven M., Yoshikawa, Koichi, Clarke, Ian D., Danovi, Davide, Stricker, Stefan, Russell, Roslin, Bayani, Jane, Head, Renee, Lee, Marco, Bernstein, Mark, Squire, Jeremy A., Smith, Austin, Dirks, Peter

“…Human brain tumors appear to have a hierarchical cellular organization suggestive of a stem cell foundation. In vitro expansion of the putative cancer stem…”
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Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells by Rajakulendran, Nishani, Rowland, Katherine J, Selvadurai, Hayden J, Ahmadi, Moloud, Park, Nicole I, Naumenko, Sergey, Dolma, Sonam, Ward, Ryan J, So, Milly, Lee, Lilian, MacLeod, Graham, Pasiliao, Clarissa, Brandon, Caroline, Clarke, Ian D, Cusimano, Michael D, Bernstein, Mark, Batada, Nizar, Angers, Stephane, Dirks, Peter B

“…Developmental signal transduction pathways act diversely, with context-dependent roles across systems and disease types. Glioblastomas (GBMs), which are the…”
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IQGAP1 protein specifies amplifying cancer cells in glioblastoma multiforme by BALENCI, Laurent, CLARKE, Ian D, DIRKS, Peter B, ASSARD, Nicole, DUCRAY, Francois, JOUVET, Anne, BELIN, Marie-Francoise, HONNORAT, Jerome, BAUDIER, Jacques

“…The accurate identification and thorough characterization of tumorigenic cells in glioblastomas are essential to enhance our understanding of their malignant…”
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Identification of a cancer stem cell in human brain tumors by SINGH, Sheila K, CLARKE, Ian D, TERASAKI, Mizuhiko, BONN, Victoria E, HAWKINS, Cynthia, SQUIRE, Jeremy, DIRKS, Peter B

“…Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, there is overwhelming evidence…”
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Cancer stem cells in nervous system tumors by Singh, Sheila K, Clarke, Ian D, Hide, Takuichiro, Dirks, Peter B

“…Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, evidence in leukemia and more…”
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MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin by Gallo, Marco, Coutinho, Fiona J., Vanner, Robert J., Gayden, Tenzin, Mack, Stephen C., Murison, Alex, Remke, Marc, Li, Ren, Takayama, Naoya, Desai, Kinjal, Lee, Lilian, Lan, Xiaoyang, Park, Nicole I., Barsyte-Lovejoy, Dalia, Smil, David, Sturm, Dominik, Kushida, Michelle M., Head, Renee, Cusimano, Michael D., Bernstein, Mark, Clarke, Ian D., Dick, John E., Pfister, Stefan M., Rich, Jeremy N., Arrowsmith, Cheryl H., Taylor, Michael D., Jabado, Nada, Bazett-Jones, David P., Lupien, Mathieu, Dirks, Peter B.

“…Mutations in the histone 3 variant H3.3 have been identified in one-third of pediatric glioblastomas (GBMs), but not in adult tumors. Here we show that H3.3 is…”
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Chemical genetics reveals a complex functional ground state of neural stem cells by Tyers, Mike, Dirks, Peter B, Diamandis, Phedias, Wildenhain, Jan, Clarke, Ian D, Sacher, Adrian G, Graham, Jeremy, Bellows, David S, Ling, Erick K M, Ward, Ryan J, Jamieson, Leanne G

“…The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases…”
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Brain Cancer Stem Cells: A Level Playing Field by Pollard, Steven, Clarke, Ian D., Smith, Austin, Dirks, Peter

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SINGLE CELL DERIVED CLONAL ANALYSIS OF HUMAN GLIOBLASTOMA LINKS FUNCTIONAL AND GENOMIC HETEROGENEITY by Dirks, P. B., Meyer, M., Reimand, J., Lan, X., Head, R., Zhu, X., Kushida, M., Bayani, J., Pressey, J. C., Lionel, A., Clarke, I. D., Cusimano, M., Squire, J., Scherer, S., Bernstein, M., Woodin, M. A., Bader, G. D.

“…BACKGROUND: Glioblastoma (GBM) is a cancer comprised of morphologically, genetically and phenotypically diverse cells. However, an understanding of the…”
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