Search Results - "CLARKE, F"

Clinical and Therapeutic Implications of Cancer Stem Cells by Clarke, Michael F

“…Cancers arise in tissues that can replicate and self-renew. Like normal tissues, cancers can replenish themselves, grow, and metastasize because of stem cells…”
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Why we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat- and reward-elicited responses by Roberts, Angela C., Clarke, Hannah F.

“…The ventromedial prefrontal cortex (vmPFC) is consistently implicated in the cognitive and emotional symptoms of many psychiatric disorders, but the causal…”
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High pH in beef longissimus thoracis reduces muscle fibre transverse shrinkage and light scattering which contributes to the dark colour by Hughes, J., Clarke, F., Purslow, P., Warner, R.

“…Most studies have focused on myoglobin regarding meat colour development, with little focus on the contribution of muscle structure and light scattering. Our…”
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The 2019/2020 mega-fires exposed Australian ecosystems to an unprecedented extent of high-severity fire by Collins, Luke, Bradstock, Ross A, Clarke, Hamish, Clarke, Michael F, Nolan, Rachael H, Penman, Trent D

“…Abstract Extreme fire seasons characterised by very large ‘mega-fires’ have demonstrably increased area burnt across forested regions globally. However, the…”
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Single-cell transcriptional diversity is a hallmark of developmental potential by Gulati, Gunsagar S, Sikandar, Shaheen S, Wesche, Daniel J, Manjunath, Anoop, Bharadwaj, Anjan, Berger, Mark J, Ilagan, Francisco, Kuo, Angera H, Hsieh, Robert W, Cai, Shang, Zabala, Maider, Scheeren, Ferenc A, Lobo, Neethan A, Qian, Dalong, Yu, Feiqiao B, Dirbas, Frederick M, Clarke, Michael F, Newman, Aaron M

“…Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular differentiation trajectories. However, inferring both the state and…”
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Fire and biodiversity in the Anthropocene by Kelly, Luke T, Giljohann, Katherine M, Duane, Andrea, Aquilué, Núria, Archibald, Sally, Batllori, Enric, Bennett, Andrew F, Buckland, Stephen T, Canelles, Quim, Clarke, Michael F, Fortin, Marie-Josée, Hermoso, Virgilio, Herrando, Sergi, Keane, Robert E, Lake, Frank K, McCarthy, Michael A, Morán-Ordóñez, Alejandra, Parr, Catherine L, Pausas, Juli G, Penman, Trent D, Regos, Adrián, Rumpff, Libby, Santos, Julianna L, Smith, Annabel L, Syphard, Alexandra D, Tingley, Morgan W, Brotons, Lluís

“…Fire has been a source of global biodiversity for millions of years. However, interactions with anthropogenic drivers such as climate change, land use, and…”
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Differences in light scattering between pale and dark beef longissimus thoracis muscles are primarily caused by differences in the myofilament lattice, myofibril and muscle fibre transverse spacings by Hughes, J., Clarke, F., Li, Y., Purslow, P., Warner, R.

“…Beef colour is essential to consumer acceptability with dark muscle colours being problematic. Dark meat has less light scattering but the mechanisms are…”
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Exercise and associated dietary extremes impact on gut microbial diversity by Clarke, Siobhan F, Murphy, Eileen F, O'Sullivan, Orla, Lucey, Alice J, Humphreys, Margaret, Hogan, Aileen, Hayes, Paula, O'Reilly, Maeve, Jeffery, Ian B, Wood-Martin, Ruth, Kerins, David M, Quigley, Eamonn, Ross, R Paul, O'Toole, Paul W, Molloy, Michael G, Falvey, Eanna, Shanahan, Fergus, Cotter, Paul D

“…The commensal microbiota, host immunity and metabolism participate in a signalling network, with diet influencing each component of this triad. In addition to…”
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The biology of cancer stem cells by Lobo, Neethan A, Shimono, Yohei, Qian, Dalong, Clarke, Michael F

“…Cancers originally develop from normal cells that gain the ability to proliferate aberrantly and eventually turn malignant. These cancerous cells then grow…”
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Cancer stem cells: models and concepts by Dalerba, Piero, Cho, Robert W, Clarke, Michael F

“…Although monoclonal in origin, most tumors appear to contain a heterogeneous population of cancer cells. This observation is traditionally explained by…”
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Self-renewal and solid tumor stem cells by Al-Hajj, Muhammad, Clarke, Michael F

“…Solid tumors arise in organs that contain stem cell populations. The tumors in these tissues consist of heterogeneous populations of cancer cells that differ…”
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Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex by Alexander, Laith, Gaskin, Philip L.R., Sawiak, Stephen J., Fryer, Tim D., Hong, Young T., Cockcroft, Gemma J., Clarke, Hannah F., Roberts, Angela C.

“…Anhedonia is a core symptom of depression, but the underlying neurobiological mechanisms are unknown. Correlative neuroimaging studies implicate dysfunction…”
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Syncopation, body-movement and pleasure in groove music by Witek, Maria A G, Clarke, Eric F, Wallentin, Mikkel, Kringelbach, Morten L, Vuust, Peter

“…Moving to music is an essential human pleasure particularly related to musical groove. Structurally, music associated with groove is often characterised by…”
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Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models by Murphy, E F, Cotter, P D, Healy, S, Marques, T M, O'Sullivan, O, Fouhy, F, Clarke, S F, O'Toole, P W, Quigley, E M, Stanton, C, Ross, P R, O'Doherty, R M, Shanahan, F

“…Increased efficiency of energy harvest, due to alterations in the gut microbiota (increased Firmicutes and decreased Bacteroidetes), has been implicated in…”
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CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer by Dalerba, Piero, Sahoo, Debashis, Paik, Soonmyung, Guo, Xiangqian, Yothers, Greg, Song, Nan, Wilcox-Fogel, Nate, Forgó, Erna, Rajendran, Pradeep S, Miranda, Stephen P, Hisamori, Shigeo, Hutchison, Jacqueline, Kalisky, Tomer, Qian, Dalong, Wolmark, Norman, Fisher, George A, van de Rijn, Matt, Clarke, Michael F

“…CDX2 is expressed in most colon cancers, but approximately 4% do not express this transcription factor. Lack of CDX2 expression marks a subset of cancers with…”
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A high rigor temperature, not sarcomere length, determines light scattering properties and muscle colour in beef M. sternomandibularis meat and muscle fibres by Hughes, J., Clarke, F., Purslow, P., Warner, R.

“…Beef meat colour is impacted by both myoglobin status and the light scattering properties of the muscle, and the specific causative scattering elements of the…”
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Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy by Dylla, Scott J, Beviglia, Lucia, Park, In-Kyung, Chartier, Cecile, Raval, Janak, Ngan, Lucy, Pickell, Kellie, Aguilar, Jorge, Lazetic, Sasha, Smith-Berdan, Stephanie, Clarke, Michael F, Hoey, Tim, Lewicki, John, Gurney, Austin L

“…Patients generally die of cancer after the failure of current therapies to eliminate residual disease. A subpopulation of tumor cells, termed cancer stem cells…”
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The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells by Liu, Rui, Wang, Xinhao, Chen, Grace Y, Dalerba, Piero, Gurney, Austin, Hoey, Timothy, Sherlock, Gavin, Lewicki, John, Shedden, Kerby, Clarke, Michael F

“…A small population of distinctive breast-cancer cells can recapitulate an entire breast cancer when injected into immunodeficient mice. These cells express a…”
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Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat by Alexander, Laith, Wood, Christian M., Gaskin, Philip L. R., Sawiak, Stephen J., Fryer, Tim D., Hong, Young T., McIver, Lauren, Clarke, Hannah F., Roberts, Angela C.

“…Stress-related disorders such as depression and anxiety are characterized by enhanced negative emotion and physiological dysfunction. Whilst elevated activity…”
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The mental health crisis of expectant women in the UK: effects of the COVID-19 pandemic on prenatal mental health, antenatal attachment and social support by Filippetti, Maria Laura, Clarke, Alasdair D F, Rigato, Silvia

“…Pregnancy has been shown to be times in a woman's life particularly prone to mental health issues, however a substantial percentage of mothers report…”
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