Search Results - "CLARKE, A."

Inhibitors of cyclin-dependent kinases as cancer therapeutics by Whittaker, Steven R, Mallinger, Aurélie, Workman, Paul, Clarke, Paul A

“…Over the past two decades there has been a great deal of interest in the development of inhibitors of the cyclin-dependent kinases (CDKs). This attention…”
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3D printed circuit splitter and flow restriction devices for multiple patient lung ventilation using one anaesthesia workstation or ventilator by Clarke, A. L.

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Temperature and the Metabolic Theory of Ecology by Clarke, A.

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Hysterectomy-Corrected Uterine Corpus Cancer Incidence Trends and Differences in Relative Survival Reveal Racial Disparities and Rising Rates of Nonendometrioid Cancers by Clarke, Megan A, Devesa, Susan S, Harvey, Summer V, Wentzensen, Nicolas

“…Uterine corpus cancer incidence rates have been projected to increase, a prediction often attributed to the obesity epidemic. However, correct estimation of…”
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Impact of COVID-19 on the Endocrine System: A Mini-review by Clarke, Sophie A, Abbara, Ali, Dhillo, Waljit S

“…The coronavirus disease 2019 (COVID-19) pandemic continues to exert a significant impact on global health care systems, causing devastating mortality and…”
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Impact of COVID-19 on cervical cancer screening: Challenges and opportunities to improving resilience and reduce disparities by Wentzensen, Nicolas, Clarke, Megan A., Perkins, Rebecca B.

“…The COVID-19 pandemic has a major impact on a wide range of health outcomes. Disruptions of elective health services related to cervical screening, management…”
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Is There a Universal Temperature Dependence of Metabolism? by Clarke, A.

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THEY, THEM, AND THEIRS by Clarke, Jessica A.

“…Nonbinary gender identities have quickly gone from obscurity to prominence in American public life, with growing acceptance of gender-neutral pronouns, such as…”
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SEX ASSIGNED AT BIRTH by Clarke, Jessica A.

“…Transgender rights discussions often turn on the distinction between “gender identity” and “sex assigned at birth.” Gender identity is a person’s own internal…”
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New genomic technologies for multi-cancer early detection: Rethinking the scope of cancer screening by Hackshaw, Allan, Clarke, Christina A., Hartman, Anne-Renee

“…Cancers other than breast, colorectal, cervical, and lung do not have guideline-recommended screening. New multi-cancer early detection (MCED) tests—using a…”
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A new Paleogene fossil and a new dataset for waterfowl (Aves: Anseriformes) clarify phylogeny, ecological evolution, and avian evolution at the K-Pg Boundary by Musser, Grace, Clarke, Julia A

“…Despite making up one of the most ecologically diverse groups of living birds, comprising soaring, diving and giant flightless taxa, the evolutionary…”
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Discovery of small molecule cancer drugs: Successes, challenges and opportunities by Hoelder, Swen, Clarke, Paul A., Workman, Paul

“…The discovery and development of small molecule cancer drugs has been revolutionised over the last decade. Most notably, we have moved from a one-size-fits-all…”
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Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer by Frame, Sheelagh, Saladino, Chiara, MacKay, Craig, Atrash, Butrus, Sheldrake, Peter, McDonald, Edward, Clarke, Paul A, Workman, Paul, Blake, David, Zheleva, Daniella

“…Cyclin-dependent kinases (CDKs) contribute to the cancer hallmarks of uncontrolled proliferation and increased survival. As a result, over the last two decades…”
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Drugging PI3K in cancer: refining targets and therapeutic strategies by Yap, Timothy A, Bjerke, Lynn, Clarke, Paul A, Workman, Paul

“…Highlights • PI3K is an important target for innovative anticancer drug development and precision medicine. • Over 30 small molecule PI3K inhibitors are…”
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Hydroxychloroquine Blood Levels in Systemic Lupus Erythematosus: Clarifying Dosing Controversies and Improving Adherence by Durcan, Laura, Clarke, William A, Magder, Laurence S, Petri, Michelle

“…Hydroxychloroquine (HCQ) is used for its effect on systemic lupus erythematosus (SLE) disease activity and longterm benefits. This can be limited by adherence…”
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Strategies for the construction of tetrahydropyran rings in the synthesis of natural products by Nasir, Nadiah Mad, Ermanis, Kristaps, Clarke, Paul A

“…This review focuses on the methodology used for the construction of tetrahydropyran (THP) rings in the synthesis of natural products over the last seven years…”
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Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment by Abbara, Ali, Clarke, Sophie A, Dhillo, Waljit S

“…Abstract Infertility affects one in six of the population and increasingly couples require treatment with assisted reproductive techniques. In vitro…”
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Thyroid Function Before, During, and After COVID-19 by Khoo, Bernard, Tan, Tricia, Clarke, Sophie A, Mills, Edouard G, Patel, Bijal, Modi, Manish, Phylactou, Maria, Eng, Pei Chia, Thurston, Layla, Alexander, Emma C, Meeran, Karim, Comninos, Alexander N, Abbara, Ali, Dhillo, Waljit S

“…Abstract Context The effects of COVID-19 on the thyroid axis remain uncertain. Recent evidence has been conflicting, with both thyrotoxicosis and suppression…”
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Design and Tailoring of Alloys for Additive Manufacturing by Pollock, T. M., Clarke, A. J., Babu, S. S.

“…Additive manufacturing (AM) promises a major transformation for manufacturing of metallic components for aerospace, medical, nuclear, and energy applications…”
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The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire by Edwards, Marcus J., White, Gaye F., Butt, Julea N., Richardson, David J., Clarke, Thomas A.

“…A growing number of bacteria are recognized to conduct electrons across their cell envelope, and yet molecular details of the mechanisms supporting this…”
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