Search Results - "CLARK, Marcus R"

The emerging role of the inflammasome in kidney diseases by Chang, Anthony, Ko, Kichul, Clark, Marcus R

“…PURPOSE OF REVIEWTo focus on the latest data that elucidate the role of the NLRP3 inflammasome in kidney diseases. RECENT FINDINGSThe NLRP3 inflammasome is not…”
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Specific in situ inflammatory states associate with progression to renal failure in lupus nephritis by Abraham, Rebecca, Durkee, Madeleine S, Ai, Junting, Veselits, Margaret, Casella, Gabriel, Asano, Yuta, Chang, Anthony, Ko, Kichul, Oshinsky, Charles, Peninger, Emily, Giger, Maryellen L, Clark, Marcus R

“…BACKGROUNDIn human lupus nephritis (LN), tubulointerstitial inflammation (TII) on biopsy predicts progression to end-stage renal disease (ESRD). However, only…”
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Novel specialized cell state and spatial compartments within the germinal center by Kennedy, Domenick E., Okoreeh, Michael K., Maienschein-Cline, Mark, Ai, Junting, Veselits, Margaret, McLean, Kaitlin C., Dhungana, Yogesh, Wang, Hong, Peng, Junmin, Chi, Hongbo, Mandal, Malay, Clark, Marcus R.

“…Within germinal centers (GCs), complex and highly orchestrated molecular programs must balance proliferation, somatic hypermutation and selection to both…”
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The Pathogenesis and Therapeutic Implications of Tubulointerstitial Inflammation in Human Lupus Nephritis by Clark, Marcus R., MD, Trotter, Kimberly, MD, Chang, Anthony, MD

“…Summary Nephritis is a common complication of systemic lupus erythematosus for which current therapies often prove inadequate. Current lupus nephritis…”
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RAG Represents a Widespread Threat to the Lymphocyte Genome by Teng, Grace, Maman, Yaakov, Resch, Wolfgang, Kim, Min, Yamane, Arito, Qian, Jason, Kieffer-Kwon, Kyong-Rim, Mandal, Malay, Ji, Yanhong, Meffre, Eric, Clark, Marcus R., Cowell, Lindsay G., Casellas, Rafael, Schatz, David G.

“…The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1…”
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B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage by Wong, Jason B., Hewitt, Susannah L., Heltemes-Harris, Lynn M., Mandal, Malay, Johnson, Kristen, Rajewsky, Klaus, Koralov, Sergei B., Clark, Marcus R., Farrar, Michael A., Skok, Jane A.

“…B-1a cells are long-lived, self-renewing innate-like B cells that predominantly inhabit the peritoneal and pleural cavities. In contrast to conventional B-2…”
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Compartments and Connections Within the Germinal Center by Kennedy, Domenick E, Clark, Marcus R

“…Protective high affinity antibody responses emerge through an orchestrated developmental process that occurs in germinal centers (GCs). While GCs have been…”
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Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection by Asano, Yuta, Daccache, Joe, Jain, Dharmendra, Ko, Kichul, Kinloch, Andrew, Veselits, Margaret, Wolfgeher, Donald, Chang, Anthony, Josephson, Michelle, Cunningham, Patrick, Tambur, Anat, Khan, Aly A., Pillai, Shiv, Chong, Anita S., Clark, Marcus R.

“…Intrarenal B cells in human renal allografts indicate transplant recipients with a poor prognosis, but how these cells contribute to rejection is unclear. Here…”
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Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2 by Mandal, Malay, Powers, Sarah E, Maienschein-Cline, Mark, Bartom, Elizabeth T, Hamel, Keith M, Kee, Barbara L, Dinner, Aaron R, Clark, Marcus R

“…The transcription factor STAT5 commonly activates gene transcription. Clark and colleagues show that tetrameric STAT5, induced by high concentrations of…”
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In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis by Chang, Anthony, Henderson, Scott G, Brandt, Daniel, Liu, Ni, Guttikonda, Riteesha, Hsieh, Christine, Kaverina, Natasha, Utset, Tammy O, Meehan, Shane M, Quigg, Richard J, Meffre, Eric, Clark, Marcus R

“…The most prevalent severe manifestation of systemic lupus erythematosus is nephritis, which is characterized by immune complex deposition, inflammation, and…”
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A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation by Ochiai, Kyoko, Maienschein-Cline, Mark, Mandal, Malay, Triggs, Joseph R, Bertolino, Eric, Sciammas, Roger, Dinner, Aaron R, Clark, Marcus R, Singh, Harinder

“…Cycling and cell cycle–arrested pre-B cells both express pre-BCRs, but whether qualitative differences exist in downstream signaling pathways remains…”
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In Situ Humoral Immunity to Vimentin in HLA-DRB103 + Patients With Pulmonary Sarcoidosis by Kinloch, Andrew J, Kaiser, Ylva, Wolfgeher, Don, Ai, Junting, Eklund, Anders, Clark, Marcus R, Grunewald, Johan

“…Vimentin has been implicated in pulmonary sarcoidosis as a T-cell autoantigen, particularly in the context of , the Vα2.3/Vβ22 T-cell receptor (TCR), and…”
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Positive and negative selection shape the human naive B cell repertoire by Chen, Jeff W, Schickel, Jean-Nicolas, Tsakiris, Nikolaos, Sng, Joel, Arbogast, Florent, Bouis, Delphine, Parisi, Daniele, Gera, Ruchi, Boeckers, Joshua M, Delmotte, Fabien R, Veselits, Margaret, Schuetz, Catharina, Jacobsen, Eva-Maria, Posovszky, Carsten, Schulz, Ansgar S, Schwarz, Klaus, Clark, Marcus R, Menard, Laurence, Meffre, Eric

“…Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection…”
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Ikaros and Aiolos Inhibit Pre-B-Cell Proliferation by Directly Suppressing c-Myc Expression by Ma, Shibin, Pathak, Simanta, Mandal, Malay, Trinh, Long, Clark, Marcus R., Lu, Runqing

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis by Mandal, Malay, Maienschein-Cline, Mark, Maffucci, Patrick, Veselits, Margaret, Kennedy, Domenick E., McLean, Kaitlin C., Okoreeh, Michael K., Karki, Sophiya, Cunningham-Rundles, Charlotte, Clark, Marcus R.

“…Transcription factor (TF) networks determine cell fate in hematopoiesis. However, how TFs cooperate with other regulatory mechanisms to instruct transcription…”
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Vimentin Is a Dominant Target of In Situ Humoral Immunity in Human Lupus Tubulointerstitial Nephritis by Kinloch, Andrew J., Chang, Anthony, Ko, Kichul, Henry Dunand, Carole J., Henderson, Scott, Maienschein‐Cline, Mark, Kaverina, Natalya, Rovin, Brad H., Salgado Ferrer, Marlene, Wolfgeher, Don, Liarski, Vladimir, Haddon, D. James, Utz, Paul J., Wilson, Patrick C., Clark, Marcus R.

“…Objective In lupus nephritis (LN), severe tubulointerstitial inflammation (TII) predicts progression to renal failure. Severe TII is associated with tertiary…”
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STAT3 signaling in B cells controls germinal center zone organization and recycling by Fike, Adam J., Chodisetti, Sathi Babu, Wright, Nathaniel E., Bricker, Kristen N., Domeier, Phillip P., Maienschein-Cline, Mark, Rosenfeld, Aaron M., Luckenbill, Sara A., Weber, Julia L., Choi, Nicholas M., Luning Prak, Eline T., Mandal, Malay, Clark, Marcus R., Rahman, Ziaur S.M.

“…Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we show a B cell-intrinsic role for…”
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Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development by Ochiai, Kyoko, Mandal, Malay, Georgopoulos, Katia, Singh, Harinder, Clark, Marcus R, Powers, Sarah E, Kee, Barbara L

“…How signals through the pre–B cell antigen receptor (pre-BCR) and IL-7 receptor (IL-7R) coordinate population expansion of pre-B cells with subsequent…”
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Machine Learning to Quantify In Situ Humoral Selection in Human Lupus Tubulointerstitial Inflammation by Kinloch, Andrew J, Asano, Yuta, Mohsin, Azam, Henry, Carole, Abraham, Rebecca, Chang, Anthony, Labno, Christine, Wilson, Patrick C, Clark, Marcus R

“…In human lupus nephritis, tubulointerstitial inflammation (TII) is associated with expansion of B cells expressing anti-vimentin antibodies (AVAs). The…”
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Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes by Veselits, Margaret, Tanaka, Azusa, Lipkowitz, Stanley, O'Neill, Shannon, Sciammas, Roger, Finnegan, Alison, Zhang, Jian, Clark, Marcus R

“…Casitas B-lineage lymphoma-b (Cbl-b) is a ubiquitin ligase (E3) that modulates signaling by tagging molecules for degradation. It is a complex protein with…”
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