Search Results - "CLARK, Jemma"

Selective Synthesis of Cyclooctanoids by Radical Cyclization of Seven-Membered Lactones: Neutron Diffraction Study of the Stereoselective Deuteration of a Chiral Organosamarium Intermediate by Just-Baringo, Xavier, Clark, Jemma, Gutmann, Matthias J., Procter, David J.

“…Seven‐membered lactones undergo selective SmI2–H2O‐promoted radical cyclization to form substituted cyclooctanols. The products arise from an exo‐mode of…”
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Process Development of a Suzuki Reaction Used in the Manufacture of Lanabecestat by Ashworth, Ian W, Campbell, Andrew D, Cherryman, Janette H, Clark, Jemma, Crampton, Alex, Eden-Rump, Edward G. B, Evans, Matthew, Jones, Martin F, McKeever-Abbas, Sahar, Meadows, Rebecca E, Skilling, Kathryn, Whittaker, David T. E, Woodward, Robert L, Inglesby, Phillip A

“…We developed a scalable Suzuki process for the synthesis of lanabecestat (+)-camsylate, an active pharmaceutical ingredient that was recently investigated in a…”
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General methods for the synthesis and late-stage diversification of 2,4-substituted 7-azaindoles by Varnes, Jeffrey G., McGuire, Thomas, Meadows, Rebecca E., Barlaam, Bernard, Clark, Jemma, Cook, Calum R., Davison, Gemma, Dishington, Allan, De Savi, Chris, Donald, Craig, Grebe, Tyler, Hande, Sudhir, Hawkins, Janet, Hird, Alexander W., Holmes, Jane, Lister, Andrew, Lucas, Simon, Moore, Jane, Moore, Esther, Patel, Anil, Pike, Kurt G., Roberts, Bryan, Stark, Andrew, Stead, Darren, Thakur, Kumar, Turner, Paul, Vasbinder, Melissa, Yang, Bin

“…[Display omitted] •Methods for preparing 2,4-substituted 7-azaindoles are compared.•An iterative catalyst screen was used to optimize borylation conditions.•A…”
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Differentiation of prion protein glycoforms from naturally occurring sheep scrapie, sheep-passaged scrapie strains (CH1641 and SSBP1), bovine spongiform encephalopathy (BSE) cases and Romney and Cheviot breed sheep experimentally inoculated with BSE using two monoclonal antibodies by STACK, Michael James, CHAPLIN, Melanie Jane, CLARK, Jemma

“…A panel of ruminant brain tissues were subjected to a Western immunoblotting technique using two monoclonal antibodies (mAbs). The resultant prion protein…”
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Selective Synthesis of Cyclooctanoids by Radical Cyclization of Seven-Membered Lactones: Neutron Diffraction Study of the Stereoselective Deuteration of a Chiral Organosamarium Intermediate by Just-Baringo, Xavier, Clark, Jemma, Gutmann, Matthias J., Procter, David J.

“…Seven‐membered lactones undergo selective SmI2–H2O‐promoted radical cyclization to form substituted cyclooctanols. The products arise from an exo‐mode of…”
Get full text