Search Results - "CLARK, JOHN I."

The significance of growth shells in development of symmetry, transparency, and refraction of the human lens by Greiling, Teri M, Clark, Judy M, Clark, John I

“…Human visual function depends on the biological lens, a biconvex optical element formed by coordinated, synchronous generation of growth shells produced from…”
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Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome by Moncaster, Juliet A, Pineda, Roberto, Moir, Robert D, Lu, Suqian, Burton, Mark A, Ghosh, Joy G, Ericsson, Maria, Soscia, Stephanie J, Mocofanescu, Anca, Folkerth, Rebecca D, Robb, Richard M, Kuszak, Jer R, Clark, John I, Tanzi, Rudolph E, Hunter, David G, Goldstein, Lee E

“…Down syndrome (DS, trisomy 21) is the most common chromosomal disorder and the leading genetic cause of intellectual disability in humans. In DS, triplication…”
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A method to prevent protein delocalization in imaging mass spectrometry of non-adherent tissues: application to small vertebrate lens imaging by Anderson, David M. G., Floyd, Kyle A., Barnes, Stephen, Clark, Judy M., Clark, John I., Mchaourab, Hassane, Schey, Kevin L.

“…MALDI imaging requires careful sample preparation to obtain reliable, high-quality images of small molecules, peptides, lipids, and proteins across tissue…”
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Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens by Gokhin, David S, Nowak, Roberta B, Kim, Nancy E, Arnett, Ernest E, Chen, Albert C, Sah, Robert L, Clark, John I, Fowler, Velia M

“…The basis for mammalian lens fiber cell organization, transparency, and biomechanical properties has contributions from two specialized cytoskeletal systems:…”
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Shotgun Identification of Protein Modifications from Protein Complexes and Lens Tissue by MacCoss, Michael J., McDonald, W. Hayes, Saraf, Anita, Sadygov, Rovshan, Clark, Judy M., Tasto, Joseph J., Gould, Kathleen L., Wolters, Dirk, Washburn, Michael, Weiss, Avery, Clark, John I., Yates, John R.

“…Large-scale genomics has enabled proteomics by creating sequence infrastructures that can be used with mass spectrometry data to identify proteins. Although…”
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Multiple sites in αB-crystallin modulate its interactions with desmin filaments assembled in vitro by Houck, Scott A, Landsbury, Andrew, Clark, John I, Quinlan, Roy A

“…The β3- and β8-strands and C-terminal residues 155-165 of αB-crystallin were identified by pin arrays as interaction sites for various client proteins…”
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Insights into the biochemical and biophysical mechanisms mediating the longevity of the transparent optics of the eye lens by Quinlan, Roy A., Clark, John I.

“…In the human eye, a transparent cornea and lens combine to form the “refracton” to focus images on the retina. This requires the refracton to have a high…”
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Functional sequences in human alphaB crystallin by Clark, John I.

“…Human alphaB crystallin (HspB5) contains the alpha crystallin core domain, a series of antiparallel beta-strands organized into the characteristic beta…”
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Genome sequencing of idiopathic pulmonary fibrosis in conjunction with a medical school human anatomy course by Kumar, Akash, Dougherty, Max, Findlay, Gregory M, Geisheker, Madeleine, Klein, Jason, Lazar, John, Machkovech, Heather, Resnick, Jesse, Resnick, Rebecca, Salter, Alexander I, Talebi-Liasi, Faezeh, Arakawa, Christopher, Baudin, Jacob, Bogaard, Andrew, Salesky, Rebecca, Zhou, Qian, Smith, Kelly, Clark, John I, Shendure, Jay, Horwitz, Marshall S

“…Even in cases where there is no obvious family history of disease, genome sequencing may contribute to clinical diagnosis and management. Clinical application…”
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Hemoglobin interactions with αB crystallin: a direct test of sensitivity to protein instability by Clark, Tyler J W, Houck, Scott A, Clark, John I

“…As a small stress response protein, human αB crystallin, detects protein destabilization that can alter structure and function to cause self assembly of…”
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Self-assembly of protein aggregates in ageing disorders: the lens and cataract model by Clark, John I.

“…Cataract, neurodegenerative disease, macular degeneration and pathologies of ageing are often characterized by the slow progressive destabilization of proteins…”
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Chaperone-like activity revealed in the matricellular protein SPARC by Emerson, Ryan O., Sage, E. Helene, Ghosh, Joy G., Clark, John I.

“…SPARC (Secreted Protein, Acidic and Rich in Cysteine) is a matricellular glycoprotein that modulates cell proliferation, adhesion, migration, and extracellular…”
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In vivo quasi-elastic light scattering detects molecular changes in the lenses of adolescents with Down syndrome by Sarangi, Srikant, Minaeva, Olga, Ledoux, Danielle M., Parsons, Douglas S., Moncaster, Juliet A., Black, Caitlin A., Hollander, Jeffrey, Tripodis, Yorghos, Clark, John I., Hunter, David G., Goldstein, Lee E.

“…Down syndrome (DS) is the most common chromosomal disorder in humans. DS is associated with increased prevalence of several ocular sequelae, including…”
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Alzheimer's disease amyloid-β pathology in the lens of the eye by Moncaster, Juliet A., Moir, Robert D., Burton, Mark A., Chadwick, Oliver, Minaeva, Olga, Alvarez, Victor E., Ericsson, Maria, Clark, John I., McKee, Ann C., Tanzi, Rudolph E., Goldstein, Lee E.

“…Neuropathological hallmarks of Alzheimer's disease (AD) include pathogenic accumulation of amyloid-β (Aβ) peptides and age-dependent formation of amyloid…”
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Age-related loss of auditory sensitivity in the zebrafish (Danio rerio) by Zeng, Ruiyu, Brown, Andrew D., Rogers, Loranzie S., Lawrence, Owen T., Clark, John I., Sisneros, Joseph A.

“…•Zebrafish auditory threshold determination was made via an objective method.•Older AB/WIK zebrafish demonstrated lower auditory sensitivity than younger…”
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Fractal analysis of region-based vascular change in the normal and non-proliferative diabetic retina by Avakian, Arpenik, Kalina, Robert E., Helene Sage, E., Rambhia, Avni H., Elliott, Katherine E., Chuang, Elaine L., Clark, John I., Hwang, Jenq-Neng, Parsons-Wingerter, Patricia

“…Purpose. Evaluation of normal and abnormal vascular pattern in the human retina using a novel method: quantitative region-based fractal analysis. Methods…”
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Early lens development in the zebrafish: A three‐dimensional time‐lapse analysis by Greiling, Teri M.S., Clark, John I.

“…In vivo, high‐resolution, time‐lapse imaging characterized lens development in the zebrafish from 16 to 96 hr postfertilization (hpf). In zebrafish, the lens…”
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The occhiolino (occ) mutant Zebrafish, a model for development of the optical function in the biological lens by Aose, Masamoto, Linbo, Tor H., Lawrence, Owen, Senoo, Tadashi, Raible, David W., Clark, John I.

“…Background: Zebrafish visual function depends on quality optics. An F3 screen for developmental mutations in the Zebrafish nervous system was conducted in…”
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Interactions between Important Regulatory Proteins and Human αB Crystallin by Ghosh, Joy G, Shenoy, Ananth K, Clark, John I

“…Protein pin arrays assessed interactions between αB crystallin and 12 regulatory proteins, including EGF, FGF-2, IGF-1, NGF-β, TGF-β, VEGF, insulin, β-catenin,…”
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In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans by Minaeva, Olga, Sarangi, Srikant, Ledoux, Danielle M, Moncaster, Juliet A, Parsons, Douglas S, Washicosky, Kevin J, Black, Caitlin A, Weng, Frank J, Ericsson, Maria, Moir, Robert D, Tripodis, Yorghos, Clark, John I, Tanzi, Rudolph E, Hunter, David G, Goldstein, Lee E

“…Abstract The absence of clinical tools to evaluate individual variation in the pace of aging represents a major impediment to understanding aging and…”
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