Search Results - "CLARK, J. I"

Axitinib versus sorafenib in advanced renal cell carcinoma: subanalyses by prior therapy from a randomised phase III trial by Escudier, B, Michaelson, M D, Motzer, R J, Hutson, T E, Clark, J I, Lim, H Y, Porfiri, E, Zalewski, P, Kannourakis, G, Staehler, M, Tarazi, J, Rosbrook, B, Cisar, L, Hariharan, S, Kim, S, Rini, B I

“…Background: In the AXIS trial, axitinib prolonged progression-free survival (PFS) vs sorafenib in patients with advanced renal cell carcinoma (RCC) previously…”
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Immune checkpoint inhibitors in advanced renal cell carcinoma: experience to date and future directions by Atkins, M.B., Clark, J.I., Quinn, D.I.

“…In recent years, there has been dramatic expansion of the treatment armamentarium for patients with advanced renal cell carcinoma (aRCC), including drugs…”
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Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer by Almand, Bond, Clark, Joseph I, Nikitina, Ekaterina, van Beynen, James, English, Nicholas R, Knight, Stella C, Carbone, David P, Gabrilovich, Dmitry I

“…Defective dendritic cell (DC) function caused by abnormal differentiation of these cells is an important mechanism of tumor escape from immune system control…”
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Overall survival by clinical risk category for high dose interleukin-2 (HD IL-2) treated patients with metastatic renal cell cancer (mRCC): data from the PROCLAIMSM registry by Fishman, M., Dutcher, J. P., Clark, J. I., Alva, A., Miletello, G. P., Curti, B., Agarwal, Neeraj, Hauke, R., Mahoney, K. M., Moon, H., Treisman, J., Tykodi, S. S., Daniels, G., Morse, M. A., Wong, M. K. K., Kaufman, H., Gregory, N., McDermott, D. F.

“…Background Prognostic scoring systems are used to estimate the risk of mortality from metastatic renal cell carcinoma (mRCC). Outcomes from different therapies…”
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Multidisciplinary treatment of olfactory neuroblastoma: Patterns of failure and management of recurrence by Petruzzelli, G.J., MD, PhD, FACS, Howell, J.B., MD, Pederson, A., MD, Origitano, T.C., MD, PhD, FACS, Byrne, R.W., MD, Munoz, L., MD, Emami, B., MD, Clark, J.I., MD

“…Abstract Purpose Esthesioneuroblastoma is an uncommon malignancy of the head and neck for which there is no defined treatment protocol. The purpose of this…”
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Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy by Tapscott, Stephen J, Klesert, Todd R, Cho, Diane H, Clark, John I, Maylie, James, Adelman, John, Snider, Lauren, Yuen, Eric C, Soriano, Philippe

“…Expansion of a CTG trinucleotide repeat in the 3′ UTR of the gene DMPK at the DM1 locus on chromosome 19 causes myotonic dystrophy, a dominantly inherited…”
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Outpatient Biochemotherapy With Interleukin-2 and Interferon Alfa-2b in Patients With Metastatic Malignant Melanoma: Results of Two Phase II Cytokine Working Group Trials by FLAHERTY, L. E, ATKINS, M, SOROKIN, P, FISHER, R. I, APPEL, C, DU, W, SOSMAN, J, WEISS, G, CLARK, J. I, MARGOLIN, K, DUTCHER, J, GORDON, M. S, LOTZE, M, MIER, J

“…The Cytokine Working Group performed a randomized phase II trial of two outpatient biochemotherapy regimens to identify an outpatient regimen with high…”
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SPARC deficiency leads to early-onset cataractogenesis by Norose, K, Clark, JI, Syed, NA, Basu, A, Heber-Katz, E, Sage, EH, Howe, CC

“…To determine the role of SPARC (secreted protein, acidic, and rich in cysteine) in cataractogenesis by examining mice deficient in a matricellular protein…”
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Glucocorticoid Induction of the Glaucoma Gene MYOC in Human and Monkey Trabecular Meshwork Cells and Tissues by Clark, Abbot F, Steely, H. Thomas, Dickerson, Jaime E., Jr, English-Wright, Sherry, Stropki, Karen, McCartney, Mitchell D, Jacobson, Nasreen, Shepard, Allan R, Clark, John I, Matsushima, Hiroyuki, Peskind, Elaine R, Leverenz, James B, Wilkinson, Charles W, Swiderski, Ruth E, Fingert, John H, Sheffield, Val C, Stone, Edwin M

“…To examine the intracellular and extracellular expression of myocilin in the human and primate trabecular meshwork (TM) in the presence and absence of…”
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Inhibition of lens opacification during the early stages of cataract formation by Hiraoka, T, Clark, JI

“…To characterize the time period during cataract formation in which administration of pantethine inhibits lens cell opacification in the selenite model for…”
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Fibroblast Growth Factor-2 Selectively Stimulates Angiogenesis of Small Vessels in Arterial Tree by Parsons-Wingerter, Patricia, Elliott, Katherine E, Clark, John I, Farr, Andrew G

“…There is a critical need for quantifiable models of angiogenesis in vivo, and in general, differential effects of angiogenic regulators on vascular morphology…”
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The influence of grain boundary impedances on the p-type conductivity of undoped BaTiO3 ceramics by CLARK, I. J, MARQUES, F. B, SINCLAIR, D. C

“…Impedance spectroscopy is used to deconvolute the dc conductivity (sigma) of undoped BaTiO3 ceramics (about 95% of the theoretical X-ray density) into bulk…”
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Phase I trial and 2B1, a bispecific monoclonal antibody targeting c-erbB-2 and FcγRIII by WEINER, L. M, CLARK, J. I, DAVEY, M, LI, W. S, GARCIA DE PALAZZO, I, RING, D. B, ALPAUGH, R. K

“…2B1 is a bispecific murine monoclonal antibody (BsMAb) with specificity for the c-erbB-2 and Fc gamma RIII extracellular domains. This BsMAb promotes the…”
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Quantitative analysis of the microstructure of the human cornea and sclera using 2-D Fourier methods by Vaezy, S, Clark, J I

“…A two-dimensional (2-D) Fourier analysis was used to characterize the microstructure of the human cornea and sclera. The average centre-to-centre spacing of…”
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A Novel Assay of Angiogenesis in the Quail Chorioallantoic Membrane: Stimulation by bFGF and Inhibition by Angiostatin According to Fractal Dimension and Grid Intersection by Parsons-Wingerter, Patricia, Lwai, Biakhre, Yang, Mong Che, Elliott, Katherine E., Milaninia, Ali, Redlitz, Alexander, Clark, John I., Sage, E.Helene

“…In a novel assay of angiogenesis in the quail chorioallantoic membrane (CAM), we measured vascular pattern and angiogenic rate after homogeneous exposure of…”
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Digital image capture and quantification of subtle lens opacities in rodents by Seeberger, T M, Matsumoto, Y, Alizadeh, A, Fitzgerald, P G, Clark, J I

“…A rapid, sensitive, and cost-effective method is reported for the subjective and objective documentation of subtle opacities in lenses of unanesthetized…”
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Fourier and power law analysis of structural complexity in cornea and lens by Clark, J I

“…The ordered pattern of type I collagen fibrils in the transparent cornea is an example of specialization in the formation of functional ultrastructure. In…”
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Effect of Selected Anti-cataract Agents on Opacification in the Selenite Cataract Model by HIRAOKA, T., CLARK, J.I., LI, X.Y., THURSTON, G.M.

“…A systematic study of the anti-cataract activity of 14 reagents was conducted using the selenite model. The reagents or their derivatives were identified from…”
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Clinical Significance of Defective Dendritic Cell Differentiation in Cancer by Almand, B, Resser, J R, Lindman, B, Nadaf, S, Clark, J I, Kwon, E D, Carbone, D P, Gabrilovich, D I

“…Defective dendritic cell (DC) function has been described previously in cancer patients and tumor-bearing mice. It can be an important factor in the escape of…”
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Loss of Cytoskeletal Proteins and Lens Cell Opacification in the Selenite Cataract Model by MATSUSHIMA, HIROYUKI, DAVID, LARRY L., HIRAOKA, TOSHIHIKO, CLARK, JOHN I.

“…This study of lens protein composition found that some cytoskeletal proteins were degraded during the earliest stages of cataract formation. Cataract was…”
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