Search Results - "CLARK, I"

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila by Rera, Michael, Clark, Rebecca I., Walker, David W.

“…Aging is characterized by a growing risk of disease and death, yet the underlying pathophysiology is poorly understood. Indeed, little is known about how the…”
Get full text

Amyloid [beta]: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease by Clark, I A, Vissel, B

“…This review concerns how the primary inflammation preceding the generation of certain key damage-associated molecular patterns (DAMPs) arises in Alzheimer's…”
Get full text

Amyloid β: one of three danger‐associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease by Clark, I A, Vissel, B

“…This review concerns how the primary inflammation preceding the generation of certain key damage‐associated molecular patterns (DAMPs) arises in Alzheimer's…”
Get full text

Role of gut microbiota in aging-related health decline: insights from invertebrate models by Clark, Rebecca I., Walker, David W.

“…Studies in mammals, including humans, have reported age-related changes in microbiota dynamics. A major challenge, however, is to dissect the cause and effect…”
Get full text

Therapeutic implications of how TNF links apolipoprotein E, phosphorylated tau, α‐synuclein, amyloid‐β and insulin resistance in neurodegenerative diseases by Clark, I A, Vissel, B

“…While cytokines such as TNF have long been recognized as essential to normal cerebral physiology, the implications of their chronic excessive production within…”
Get full text

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality by Clark, Rebecca I., Salazar, Anna, Yamada, Ryuichi, Fitz-Gibbon, Sorel, Morselli, Marco, Alcaraz, Jeanette, Rana, Anil, Rera, Michael, Pellegrini, Matteo, Ja, William W., Walker, David W.

“…Alterations in the composition of the intestinal microbiota have been correlated with aging and measures of frailty in the elderly. However, the relationships…”
Get full text

Broader Insights into Understanding Tumor Necrosis Factor and Neurodegenerative Disease Pathogenesis Infer New Therapeutic Approaches by Clark, I A, Vissel, B

“…Proinflammatory cytokines such as tumor necrosis factor (TNF), with its now appreciated key roles in neurophysiology as well as neuropathophysiology, are…”
Get more information

How TNF was recognized as a key mechanism of disease by Clark, Ian A

“…Abstract This review summarizes the origins of the insight that excess production of pro-inflammatory cytokines caused a constellation of changes that…”
Get full text

Long-Term Results of a Randomized Trial of Surgery With or Without Preoperative Chemotherapy in Esophageal Cancer by ALLUM, William H, STENNING, Sally P, BANCEWICZ, John, CLARK, Peter I, LANGLEY, Ruth E

“…OEO2 is a randomized, controlled trial of preoperative chemotherapy in patients undergoing radical surgery for esophageal cancer. Random assignment was to…”
Get full text

Simultaneous Strength-Ductility Enhancement of a Nano-Lamellar AlCoCrFeNi2.1 Eutectic High Entropy Alloy by Cryo-Rolling and Annealing by Bhattacharjee, T., Wani, I. S., Sheikh, S., Clark, I. T., Okawa, T., Guo, S., Bhattacharjee, P. P., Tsuji, N.

“…Nano-lamellar (L1 2  + B2) AlCoCrFeNi 2.1 eutectic high entropy alloy (EHEA) was processed by cryo-rolling and annealing. The EHEA developed a novel…”
Get full text

Adult attachment and social anxiety: The mediating role of emotion regulation strategies by Read, Darryl L, Clark, Gavin I, Rock, Adam J, Coventry, William L

“…Despite extensive evidence relating attachment dimensions to maladaptive interpersonal behaviours and dysfunctional emotion regulation strategies, few studies…”
Get full text

Current Status of the AMOEBA Polarizable Force Field by Ponder, Jay W, Wu, Chuanjie, Ren, Pengyu, Pande, Vijay S, Chodera, John D, Schnieders, Michael J, Haque, Imran, Mobley, David L, Lambrecht, Daniel S, DiStasio, Robert A, Head-Gordon, Martin, Clark, Gary N. I, Johnson, Margaret E, Head-Gordon, Teresa

“…Molecular force fields have been approaching a generational transition over the past several years, moving away from well-established and well-tuned, but…”
Get full text

3-min all-out exercise test for running by Pettitt, R W, Jamnick, N, Clark, I E

“…A 3-min all-out exercise test (3 MT) estimates critical power and the curvature constant for cycle ergometry validly; however, the mode of running has not been…”
Get more information

Assessing the relationship between early maladaptive schemas and interpersonal problems using interpersonal scenarios depicting rejection by Janovsky, Thomas, Rock, Adam J, Thorsteinsson, Einar B, Clark, Gavin I, Polad, Valerie, Cosh, Suzanne

“…Background Early maladaptive schemas (EMSs) have been theorised to contribute to reoccurring interpersonal problems. This study developed a novel experimental…”
Get full text

Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial by Margolin, Kim, Prof, Ernstoff, Marc S, MD, Hamid, Omid, MD, Lawrence, Donald, MD, McDermott, David, MD, Puzanov, Igor, MD, Wolchok, Jedd D, MD, Clark, Joseph I, Prof, Sznol, Mario, MD, Logan, Theodore F, MD, Richards, Jon, MD, Michener, Tracy, PharmD, Balogh, Agnes, MS, Heller, Kevin N, MD, Hodi, F Stephen, MD

“…Summary Background Brain metastases commonly develop in patients with melanoma and are a frequent cause of death of patients with this disease. Ipilimumab…”
Get full text

Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging by Salazar, Anna M, Aparicio, Ricardo, Clark, Rebecca I, Rera, Michael, Walker, David W

“…A major challenge in the biology of aging is to understand how specific age-onset pathologies relate to the overall health of the organism. The integrity of…”
Get full text

Hybridization and range expansion in tamarisk beetles (Diorhabda spp.) introduced to North America for classical biological control by Stahlke, Amanda R., Bitume, Ellyn V., Özsoy, Zeynep A., Bean, Dan W., Veillet, Anne, Clark, Meaghan I., Clark, Eliza I., Moran, Patrick, Hufbauer, Ruth A., Hohenlohe, Paul A.

“…With the global rise of human‐mediated translocations and invasions, it is critical to understand the genomic consequences of hybridization and mechanisms of…”
Get full text

MEF2 Is an In Vivo Immune-Metabolic Switch by Clark, Rebecca I., Tan, Sharon W.S., Péan, Claire B., Roostalu, Urmas, Vivancos, Valérie, Bronda, Kévin, Pilátová, Martina, Fu, Jingqi, Walker, David W., Berdeaux, Rebecca, Geissmann, Frédéric, Dionne, Marc S.

“…Infections disturb metabolic homeostasis in many contexts, but the underlying connections are not completely understood. To address this, we use paired genetic…”
Get full text

Role of Imaging in Renal Cell Carcinoma: A Multidisciplinary Perspective by Abou Elkassem, Asser M, Lo, Simon S, Gunn, Andrew J, Shuch, Brian M, Dewitt-Foy, Molly E, Abouassaly, Robert, Vaidya, Sandeep S, Clark, Joseph I, Louie, Alexander V, Siva, Shankar, Grosu, Anca-Ligia, Smith, Andrew D

“…With the expansion in cross-sectional imaging over the past few decades, there has been an increase in the number of incidentally detected renal masses and an…”
Get full text

Pitfalls and windfalls of detecting demographic declines using population genetics in long‐lived species by Clark, Meaghan I., Fitzpatrick, Sarah W., Bradburd, Gideon S.

“…Detecting recent demographic changes is a crucial component of species conservation and management, as many natural populations face declines due to…”
Get full text