Search Results - "CLARK, B. S"

The far-reaching scope of neuroinflammation after traumatic brain injury by Simon, Dennis W., McGeachy, Mandy J., Bayır, Hülya, Clark, Robert S. B., Loane, David J., Kochanek, Patrick M.

“…Key Points Traumatic brain injury (TBI) is an important public health issue: the global incidence of TBI is on the rise, and mild, repetitive and blast…”
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Critical Role of Calpain I in Mitochondrial Release of Apoptosis-Inducing Factor in Ischemic Neuronal Injury by Cao, Guodong, Xing, Juan, Xiao, Xiao, Liou, Anthony K. F, Gao, Yanqin, Yin, Xiao-Ming, Clark, Robert S. B, Graham, Steven H, Chen, Jun

“…Loss of mitochondrial membrane integrity and release of apoptogenic factors are a key step in the signaling cascade leading to neuronal cell death in various…”
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Multicenter cohort study of out-of-hospital pediatric cardiac arrest by Moler, Frank W, Donaldson, Amy E, Meert, Kathleen, Brilli, Richard J, Nadkarni, Vinay, Shaffner, Donald H, Schleien, Charles L, Clark, Robert S. B, Dalton, Heidi J, Statler, Kimberly, Tieves, Kelly S, Hackbarth, Richard, Pretzlaff, Robert, van der Jagt, Elise W, Pineda, Jose, Hernan, Lynn, Dean, J. Michael

“…OBJECTIVES:To describe a large cohort of children with out-of-hospital cardiac arrest with return of circulation and to identify factors in the early…”
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Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children by Clark, Robert S B, Empey, Philip E, Bayır, Hülya, Rosario, Bedda L, Poloyac, Samuel M, Kochanek, Patrick M, Nolin, Thomas D, Au, Alicia K, Horvat, Christopher M, Wisniewski, Stephen R, Bell, Michael J

“…There are no therapies shown to improve outcome after severe traumatic brain injury (TBI) in humans, a leading cause of morbidity and mortality. We sought to…”
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Starving Neurons Show Sex Difference in Autophagy by Du, Lina, Hickey, Robert W., Bayir, Hülya, Watkins, Simon C., Tyurin, Vladimir A., Guo, Fengli, Kochanek, Patrick M., Jenkins, Larry W., Ren, Jin, Gibson, Greg, Chu, Charleen T., Kagan, Valerian E., Clark, Robert S.B.

“…Sex-dependent differences in adaptation to famine have long been appreciated, thought to hinge on female versus male preferences for fat versus protein…”
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Effect of dietary cellulose supplementation on gut barrier function and apoptosis in a murine model of endotoxemia by Di Caro, Valentina, Alcamo, Alicia M, Cummings, Jessica L, Clark, Robert S B, Novak, Elizabeth A, Mollen, Kevin P, Morowitz, Michael J, Aneja, Rajesh K

“…The gut plays a vital role in critical illness, and alterations in the gut structure and function have been reported in endotoxemia and sepsis models…”
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Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making by Kochanek, Patrick M, Berger, Rachel P, Bayir, Hülya, Wagner, Amy K, Jenkins, Larry W, Clark, Robert S B

“…Emerging data suggest that biomarkers of brain injury have potential utility as diagnostic, prognostic, and therapeutic adjuncts in the setting of traumatic…”
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A randomized, embedded, pragmatic, Bayesian clinical trial examining clinical decision support for high flow nasal cannula management in children with bronchiolitis: design and statistical analysis plan by Horvat, Christopher M, Suresh, Srinivasan, James, Nathan, Aneja, Rajesh K, Au, Alicia K, Berry, Scott, Blumer, Arthur, Bricker, Kelly, Clark, Robert S B, Dolinich, Heidilyn, Hahner, Sheila, Jockel, Christina, Kalivoda, Jordan, Loar, India, Marasco, Denee, Marcinick, Adrienne, Marroquin, Oscar, O'brien, Jonathan, Pelletier, Jonathan, Ramgopal, Sriram, Venkataraman, Shekhar, Angus, Derek C, Butler, Gabriella

“…High flow nasal cannula (HFNC) has been increasingly adopted in the past 2 decades as a mode of respiratory support for children hospitalized with…”
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Mechanistic characterization of nitrite‐mediated neuroprotection after experimental cardiac arrest by Dezfulian, Cameron, Kenny, Elizabeth, Lamade, Andrew, Misse, Amalea, Krehel, Nicholas, St. Croix, Claudette, Kelley, Eric E., Jackson, Travis C., Uray, Thomas, Rackley, Justin, Kochanek, Patrick M., Clark, Robert S. B., Bayir, Hulya

“…Nitrite acts as an ischemic reservoir of nitric oxide (NO) and a potent S‐nitrosating agent which reduced histologic brain injury after rat asphyxial cardiac…”
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20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats by Shaik, Jafar Sadik B, Poloyac, Samuel M, Kochanek, Patrick M, Alexander, Henry, Tudorascu, Dana L, Clark, Robert SB, Manole, Mioara D

“…Vasoconstrictive and vasodilatory eicosanoids generated after cardiac arrest (CA) may contribute to cerebral vasomotor disturbances and neurodegeneration. We…”
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Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest by Tang, Minke, Alexander, Henry, Clark, Robert SB, Kochanek, Patrick M, Kagan, Valerian E, Bayır, Hülya

“…The mechanisms leading to delayed neuronal death after asphyxial cardiac arrest (ACA) in the developing brain are unknown. This study aimed at investigating…”
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The Nuclear Splicing Factor RNA Binding Motif 5 Promotes Caspase Activation in Human Neuronal Cells, and Increases after Traumatic Brain Injury in Mice by Jackson, Travis C, Du, Lina, Janesko-Feldman, Keri, Vagni, Vincent A, Dezfulian, Cameron, Poloyac, Samuel M, Jackson, Edwin K, Clark, Robert SB, Kochanek, Patrick M

“…Splicing factors (SFs) coordinate nuclear intron/exon splicing of RNA. Splicing factor disturbances can cause cell death. RNA binding motif 5 (RBM5) and 10…”
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Prolonged Lymphopenia, Lymphoid Depletion, and Hypoprolactinemia in Children with Nosocomial Sepsis and Multiple Organ Failure by Felmet, Kate A, Hall, Mark W, Clark, Robert S. B, Jaffe, Ronald, Carcillo, Joseph A

“…Lymphopenia and lymphoid depletion occur in adults dying of sepsis. Prolactin increases Bcl-2 expression, suppresses stress-induced lymphocyte apoptosis, and…”
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Trends in Bronchiolitis ICU Admissions and Ventilation Practices: 2010-2019 by Pelletier, Jonathan H, Au, Alicia K, Fuhrman, Dana, Clark, Robert S B, Horvat, Christopher

“…To determine the changes in ICU admissions, ventilatory support, length of stay, and cost for patients with bronchiolitis in the United States. Retrospective…”
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Neuronal NOS‐mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury by Bayır, Hülya, Kagan, Valerian E., Clark, Robert S. B., Janesko‐Feldman, Keri, Rafikov, Ruslan, Huang, Zhentai, Zhang, Xiaojing, Vagni, Vincent, Billiar, Timothy R., Kochanek, Patrick M.

“…Manganese superoxide dismutase (MnSOD) provides the first line of defense against superoxide generated in mitochondria. SOD competes with nitric oxide for…”
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Autophagy is Increased after Traumatic Brain Injury in Mice and is Partially Inhibited by the Antioxidant γ-glutamylcysteinyl Ethyl Ester by Lai, Yichen, Hickey, Robert W, Chen, Yaming, Bayιr, Hülya, Sullivan, Mara L, Chu, Charleen T, Kochanek, Patrick M, Dixon, C Edward, Jenkins, Larry W, Graham, Steven H, Watkins, Simon C, Clark, Robert SB

“…Autophagy is a homeostatic process for recycling of proteins and organelles, induced by nutrient deprivation and regulated by oxygen radicals. Whether…”
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Adenosine A1 receptor knockout mice develop lethal status epilepticus after experimental traumatic brain injury by Kochanek, Patrick M, Vagni, Vincent A, Janesko, Keri L, Washington, Christopher B, Crumrine, Patricia K, Garman, Robert H, Jenkins, Larry W, Clark, Robert SB, Homanics, Gregg E, Dixon, C Edward, Schnermann, Jurgen, Jackson, Edwin K

“…Adenosine, acting at A1 receptors, exhibits anticonvulsant effects in experimental epilepsy—and inhibits progression to status epilepticus (SE). Seizures after…”
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Trends in US Pediatric Hospital Admissions in 2020 Compared With the Decade Before the COVID-19 Pandemic by Pelletier, Jonathan H, Rakkar, Jaskaran, Au, Alicia K, Fuhrman, Dana, Clark, Robert S B, Horvat, Christopher M

“…In early 2020, the United States declared a public health emergency in response to coronavirus disease 2019 (COVID-19) and implemented a variety of social…”
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The far-reaching scope of neuroinflammation after traumatic brain injury by Simon, Dennis W, McGeachy, Mandy J, Bayır, Hülya, Clark, Robert S B, Loane, David J, Kochanek, Patrick M

“…This corrects the article DOI: 10.1038/nrneurol.2017.13…”
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Increased CSF Concentrations of Myelin Basic Protein After TBI in Infants and Children: Absence of Significant Effect of Therapeutic Hypothermia by Su, E., Bell, M. J., Kochanek, P. M., Wisniewski, S. R., Bayır, H., Clark, R. S. B., Adelson, P. D., Tyler-Kabara, E. C., Janesko-Feldman, K. L., Berger, R. P.

“…Background The objectives of this study were to determine effects of severe traumatic brain injury (TBI) on cerebrospinal fluid (CSF) concentrations of myelin…”
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