Search Results - "CLARK, Andrew R"

Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration by Clark, Andrew R., Ohlmeyer, Michael

“…Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric enzyme that catalyzes the selective removal of phosphate groups from protein serine and…”
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Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis by Falconer, Jane, Murphy, Anne N., Young, Stephen P., Clark, Andrew R., Tiziani, Stefano, Guma, Monica, Buckley, Christopher D.

“…Metabolomic studies of body fluids show that immune‐mediated inflammatory diseases such as rheumatoid arthritis (RA) are associated with metabolic disruption…”
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Anti-inflammatory functions of glucocorticoid-induced genes by Clark, Andrew R.

“…There is a broad consensus that glucocorticoids (GCs) exert anti-inflammatory effects largely by inhibiting the function of nuclear factor κB (NFκB) and…”
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Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor by Clark, Andrew R, Belvisi, Maria G

“…Glucocorticoids are steroid hormones that have pleiotropic effects on development, metabolism, cognitive function and other aspects of physiology. Since the…”
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Mitochondria as Key Players in the Pathogenesis and Treatment of Rheumatoid Arthritis by Clayton, Sally A, MacDonald, Lucy, Kurowska-Stolarska, Mariola, Clark, Andrew R

“…Mitochondria are major energy-producing organelles that have central roles in cellular metabolism. They also act as important signalling hubs, and their…”
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Early Cretaceous sedimentation and orogeny on the active margin of Eurasia: Southern Central Pontides, Turkey by Okay, Aral I., Sunal, Gürsel, Sherlock, Sarah, Alt𝚤ner, Demir, Tüysüz, Okan, Kylander‐Clark, Andrew R. C., Aygül, Mesut

“…The Pontides in northern Turkey constituted part of the southern active margin of Eurasia during the Mesozoic. In the Early Cretaceous, a large submarine…”
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The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases by Clark, Andrew R, Dean, Jonathan L E

“…Twenty years ago, the first description of a tristetraprolin (TTP) knockout mouse highlighted the fundamental role of TTP in the restraint of inflammation…”
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Nonclassical Ly6C− Monocytes Drive the Development of Inflammatory Arthritis in Mice by Misharin, Alexander V., Cuda, Carla M., Saber, Rana, Turner, Jason D., Gierut, Angelica K., Haines, G. Kenneth, Berdnikovs, Sergejs, Filer, Andrew, Clark, Andrew R., Buckley, Christopher D., Mutlu, Gökhan M., Budinger, G.R. Scott, Perlman, Harris

“…Different subsets and/or polarized phenotypes of monocytes and macrophages may play distinct roles during the development and resolution of inflammation. Here,…”
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Late Paleozoic oxygenation of marine environments supported by dolomite U-Pb dating by Ben-Israel, Michal, Holder, Robert M., Nelson, Lyle L., Smith, Emily F., Kylander-Clark, Andrew R. C., Ryb, Uri

“…Understanding causal relationships between evolution and ocean oxygenation hinges on reliable reconstructions of marine oxygen levels, typically from…”
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Plate motion and a dipolar geomagnetic field at 3.25 Ga by Brenner, Alec R, Fu, Roger R, Kylander-Clark, Andrew R C, Hudak, George J, Foley, Bradford J

“…The paleomagnetic record is an archive of Earth's geophysical history, informing reconstructions of ancient plate motions and probing the core via the…”
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No sediment transport across the Tethys ocean during the latest Cretaceous: detrital zircon record from the Pontides and the Anatolide–Tauride Block by Okay, Aral I., Kylander‐Clark, Andrew R. C.

“…We report detrital zircon ages from the Upper Cretaceous (Campanian–Maastrichtian) turbiditic sandstones from the Pontides and the Anatolide–Tauride Block,…”
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Linking titanite U–Pb dates to coupled deformation and dissolution–reprecipitation by Moser, Amy C., Hacker, Bradley R., Gehrels, George E., Seward, Gareth G. E., Kylander-Clark, Andrew R. C., Garber, Joshua M.

“…Titanite U–Pb geochronology is a promising tool to date high-temperature tectonic processes, but the extent to and mechanisms by which recrystallization resets…”
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Pace of passive margin tectonism revealed by U-Pb dating of fracture-filling calcite by Amidon, William H., Kylander-Clark, Andrew R. C., Barr, Matthew N., Graf, Samuel F. I., West, David P.

“…A growing body of evidence demonstrates that Atlantic-style passive margins have experienced episodes of uplift and volcanism in response to changes in mantle…”
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Prolonged (>100 Ma) ultrahigh temperature metamorphism in the Napier Complex, East Antarctica: A petrochronological investigation of Earth's hottest crust by Clark, Chris, Taylor, Richard J. M., Kylander‐Clark, Andrew R. C., Hacker, Bradley R.

“…The Napier Complex in East Antarctica preserves a record of ultrahigh temperature (UHT) metamorphism during the late Archean to early Palaeoproterozoic. While…”
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Decoupling of zircon U–Pb and trace-element systematics driven by U diffusion in eclogite-facies zircon (Monviso meta-ophiolite, W. Alps) by Garber, Joshua M., Smye, Andrew J., Feineman, Maureen D., Kylander-Clark, Andrew R. C., Matthews, Simon

“…Zircon is widely used to date metamorphic processes, particularly due to slow cation diffusion under crustal conditions. Here, we present laser-ablation depth…”
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The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome by Haneklaus, Moritz, O’Neil, John D., Clark, Andrew R., Masters, Seth L., O’Neill, Luke A.J.

“…The NLRP3 inflammasome is a central regulator of inflammation in many common diseases, including atherosclerosis and type 2 diabetes, driving the production of…”
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The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3 by Ronkina, Natalia, Shushakova, Nelli, Tiedje, Christopher, Yakovleva, Tatiana, Tollenaere, Maxim A X, Scott, Aaron, Batth, Tanveer Singh, Olsen, Jesper Velgaard, Helmke, Alexandra, Bekker-Jensen, Simon Holst, Clark, Andrew R, Kotlyarov, Alexey, Gaestel, Matthias

“…Tristetraprolin (TTP) is an RNA-binding protein and an essential factor of posttranscriptional repression of cytokine biosynthesis in macrophages. Its activity…”
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The Role of Inspiratory Pressures in Determining the Flow Rates Though Dry Powder Inhalers; A Review by Clark, Andrew R

“…Dry powder inhalers are one of the most popular devices for delivering medication directly to the lungs of patients. Both for local action and when using the…”
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Interpreting titanite U–Pb dates and Zr thermobarometry in high-grade rocks: empirical constraints on elemental diffusivities of Pb, Al, Fe, Zr, Nb, and Ce by Holder, Robert M., Hacker, Bradley R., Seward, Gareth G. E., Kylander-Clark, Andrew R. C.

“…Length scales of compositional heterogeneity in titanite from 750 to 1000 °C metamorphic rocks from southern Madagascar were measured to provide empirical…”
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Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin by Tang, Tina, Scambler, Thomas E., Smallie, Tim, Cunliffe, Helen E., Ross, Ewan A., Rosner, Dalya R., O’Neil, John D., Clark, Andrew R.

“…In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the…”
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