The effect of physical activity and fitness on specific antibody production in college students

The purpose of this study was to determine the effect of moderate physical activity/fitness on the immune response to a defined antigen, in particular, the hemagglutinin-inhibition response to the H1 (A/Texas/36/91) and H3 (A/Johannesburg/33/94) components of the 1995-96 Influenza virus vaccine. Six...

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Bibliographic Details
Published in:	Journal of sports medicine and physical fitness Vol. 39; no. 3; pp. 233 - 239
Main Authors:	SCHULER, P. B, LLOYD, L. K, LEBLANC, P. A, CLAPP, T. A, ABADIE, B. R, COLLINS, R. K
Format:	Journal Article
Language:	English
Published:	Torino Minerva medica 01-09-1999 Edizioni Minerva Medica
Subjects:	Adolescent Adult Antibodies, Viral - blood Biological and medical sciences Body Composition College Students Exercise - physiology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Hemagglutination Inhibition Tests Hemagglutinin Glycoproteins, Influenza Virus - immunology Humans Immunobiology Influenza A virus - immunology Influenza Vaccines - immunology Male Modulation of the immune response (stimulation, suppression) Oxygen Consumption Physical Education Physical Fitness - physiology Physical exercise Human Immune response Antibody Vaccine strain Orthomyxoviridae Virus Physical fitness Influenzavirus A Influenza A virus Agglutinin Humoral immunity Immune system
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Summary:	The purpose of this study was to determine the effect of moderate physical activity/fitness on the immune response to a defined antigen, in particular, the hemagglutinin-inhibition response to the H1 (A/Texas/36/91) and H3 (A/Johannesburg/33/94) components of the 1995-96 Influenza virus vaccine. Sixty-seven volunteers 18-30 years of age (mean 21.1 + 2.3) participated in the study. Physical activity was assessed using the Stanford 7-Day Recall Questionnaire, physical fitness (VO2max) was predicted based on graded submaximal cycle ergometry. Participants were divided into six groups (lower-active/fit, moderate active/fit, and higher active/fit), based on their scores on the 7-Day Recall Questionnaire or predicted VO2max, respectively. Plasma samples were collected prior to, one, two, four, and six weeks post vaccination. A total of four separate repeated measures ANOVA were utilized to evaluate the effect of physical fitness and physical activity on the immune response to the H1 and H3 components of the vaccine. As expected, for both antigens, titers significantly increased after vaccination, with the highest titers found on week four (H1) and week six (H3), respectively. However, for both antigens, there was no difference between groups and no significant interaction. The results of this study showed no significant effect of physical fitness or physical activity on the production of specific antibody in the range of physical fitness and physical activity found within this group of college students.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0022-4707 1827-1928