Search Results - "CLAPP, D. Wade"

Selumetinib in Children with Inoperable Plexiform Neurofibromas by Gross, Andrea M, Wolters, Pamela L, Dombi, Eva, Baldwin, Andrea, Whitcomb, Patricia, Fisher, Michael J, Weiss, Brian, Kim, AeRang, Bornhorst, Miriam, Shah, Amish C, Martin, Staci, Roderick, Marie C, Pichard, Dominique C, Carbonell, Amanda, Paul, Scott M, Therrien, Janet, Kapustina, Oxana, Heisey, Kara, Clapp, D. Wade, Zhang, Chi, Peer, Cody J, Figg, William D, Smith, Malcolm, Glod, John, Blakeley, Jaishri O, Steinberg, Seth M, Venzon, David J, Doyle, L. Austin, Widemann, Brigitte C

“…Neurofibromatosis involves activation of the RAS pathway. Inhibition of MEK, a component of the pathway, with selumetinib was performed in 50 children with…”
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Fanconi Anemia Proteins Function in Mitophagy and Immunity by Sumpter, Rhea, Sirasanagandla, Shyam, Fernández, Álvaro F., Wei, Yongjie, Dong, Xiaonan, Franco, Luis, Zou, Zhongju, Marchal, Christophe, Lee, Ming Yeh, Clapp, D. Wade, Hanenberg, Helmut, Levine, Beth

“…Fanconi anemia (FA) pathway genes are important tumor suppressors whose best-characterized function is repair of damaged nuclear DNA. Here, we describe an…”
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Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis by Liao, Chung-Ping, Booker, Reid C, Brosseau, Jean-Philippe, Chen, Zhiguo, Mo, Juan, Tchegnon, Edem, Wang, Yong, Clapp, D Wade, Le, Lu Q

“…Neurofibromatosis type 1 associates with multiple neoplasms, and the Schwann cell tumor neurofibroma is the most prevalent. A hallmark feature of neurofibroma…”
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Multicenter, Prospective, Phase II and Biomarker Study of High-Dose Bevacizumab as Induction Therapy in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannoma by Plotkin, Scott R, Duda, Dan G, Muzikansky, Alona, Allen, Jeffrey, Blakeley, Jaishri, Rosser, Tena, Campian, Jian L, Clapp, D Wade, Fisher, Michael J, Tonsgard, James, Ullrich, Nicole, Thomas, Coretta, Cutter, Gary, Korf, Bruce, Packer, Roger, Karajannis, Matthias A

“…Bevacizumab treatment at 7.5 mg/kg every 3 weeks results in improved hearing in approximately 35%-40% of patients with neurofibromatosis type 2 (NF2) and…”
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Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors by Bai, Ren-Yuan, Esposito, Dominic, Tam, Ada J., McCormick, Frank, Riggins, Gregory J., Wade Clapp, D., Staedtke, Verena

“…Neurofibromatosis type 1, including the highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), is featured by the loss of functional…”
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Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial by Fisher, Michael J., Shih, Chie-Schin, Rhodes, Steven D., Armstrong, Amy E., Wolters, Pamela L., Dombi, Eva, Zhang, Chi, Angus, Steven P., Johnson, Gary L., Packer, Roger J., Allen, Jeffrey C., Ullrich, Nicole J., Goldman, Stewart, Gutmann, David H., Plotkin, Scott R., Rosser, Tena, Robertson, Kent A., Widemann, Brigitte C., Smith, Abbi E., Bessler, Waylan K., He, Yongzheng, Park, Su-Jung, Mund, Julie A., Jiang, Li, Bijangi-Vishehsaraei, Khadijeh, Robinson, Coretta Thomas, Cutter, Gary R., Korf, Bruce R., Blakeley, Jaishri O., Clapp, D. Wade

“…Neurofibromatosis type 1 (NF1) plexiform neurofibromas (PNs) are progressive, multicellular neoplasms that cause morbidity and may transform to sarcoma…”
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Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanisms in Vivo by Wang, Zhanxiang, Oh, Eunjin, Clapp, D. Wade, Chernoff, Jonathan, Thurmond, Debbie C.

“…The p21-activated kinase PAK1 is implicated in tumorigenesis, and efforts to inhibit PAK1 signaling as a means to induce tumor cell apoptosis are underway…”
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Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase by Molosh, Andrei I, Johnson, Philip L, Spence, John P, Arendt, David, Federici, Lauren M, Bernabe, Cristian, Janasik, Steven P, Segu, Zaneer M, Khanna, Rajesh, Goswami, Chirayu, Zhu, Weiguo, Park, Su-Jung, Li, Lang, Mechref, Yehia S, Clapp, D Wade, Shekhar, Anantha

“…Neurofibromatosis type 1 (NF1) is associated with social dysfunction in children. Here the authors show that Nf1 heterozygous mice have deficits in social…”
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Mast cells and the neurofibroma microenvironment by Staser, Karl, Yang, Feng-Chun, Clapp, D. Wade

“…Neurofibromatosis type 1 (NF1) is the most common genetic disorder with a predisposition to malignancy and affects 1 in 3500 persons worldwide. NF1 is caused…”
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A Collaborative Model for Accelerating the Discovery and Translation of Cancer Therapies by Maertens, Ophélia, McCurrach, Mila E, Braun, Benjamin S, De Raedt, Thomas, Epstein, Inbal, Huang, Tannie Q, Lauchle, Jennifer O, Lee, Hyerim, Wu, Jianqiang, Cripe, Timothy P, Clapp, D Wade, Ratner, Nancy, Shannon, Kevin, Cichowski, Karen

“…Preclinical studies using genetically engineered mouse models (GEMM) have the potential to expedite the development of effective new therapies; however, they…”
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Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial by Robertson, Kent A, Dr, Nalepa, Grzegorz, MD, Yang, Feng-Chun, MD, Bowers, Daniel C, MD, Ho, Chang Y, MD, Hutchins, Gary D, Prof, Croop, James M, Prof, Vik, Terry A, MD, Denne, Scott C, Prof, Parada, Luis F, Prof, Hingtgen, Cynthia M, MD, Walsh, Laurence E, MD, Yu, Menggang, PhD, Pradhan, Kamnesh R, MD, Edwards-Brown, Mary K, Prof, Cohen, Mervyn D, Prof, Fletcher, James W, Prof, Travers, Jeffrey B, Prof, Staser, Karl W, PhD, Lee, Melissa W, BS, Sherman, Marcie R, BS, Davis, Cynthia J, RN, Miller, Lucy C, RN, Ingram, David A, Prof, Clapp, D Wade, Prof

“…Summary Background Plexiform neurofibromas are slow-growing chemoradiotherapy-resistant tumours arising in patients with neurofibromatosis type 1 (NF1)…”
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Fanconi anaemia and cancer: an intricate relationship by Nalepa, Grzegorz, Clapp, D. Wade

“…Key Points Fanconi anaemia (FA) is a complex genetic syndrome associated with risk of congenital malformations, bone marrow failure and cancer. Diagnosis of FA…”
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A molecular basis for neurofibroma-associated skeletal manifestations in NF1 by Ma, Yun, Gross, Andrea M., Dombi, Eva, Pemov, Alexander, Choi, Kwangmin, Chaney, Katherine, Rhodes, Steven D., Angus, Steven P., Sciaky, Noah, Clapp, D. Wade, Ratner, Nancy, Widemann, Brigitte C., Rios, Jonathan J., Elefteriou, Florent

“…Purpose Plexiform neurofibromas (pNF) develop in children with neurofibromatosis type 1 (NF1) and can be associated with several skeletal comorbidities…”
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PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2) by Hawley, Eric, Gehlhausen, Jeffrey, Karchugina, Sofiia, Chow, Hoi-Yee, Araiza-Olivera, Daniela, Radu, Maria, Smith, Abbi, Burks, Ciersten, Jiang, Li, Li, Xiaohong, Bessler, Waylan, Masters, Andrea, Edwards, Donna, Burgin, Callie, Jones, David, Yates, Charles, Clapp, D Wade, Chernoff, Jonathan, Park, Su-Jung

“…Abstract Neurofibromatosis Type II (NF2) is an autosomal dominant cancer predisposition syndrome in which germline haploinsufficiency at the NF2 gene confers a…”
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Pathogenesis of plexiform neurofibroma: tumor-stromal/hematopoietic interactions in tumor progression by Staser, Karl, Yang, Feng-Chun, Clapp, D Wade

“…Neurofibromatosis type 1 (NF1) is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene. A…”
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Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 1 by Mund, Julie A, Park, SuJung, Smith, Abbi E, He, Yongzheng, Jiang, Li, Hawley, Eric, Roberson, Michelle J, Mitchell, Dana K, Abu-Sultanah, Mohannad, Yuan, Jin, Bessler, Waylan K, Sandusky, George, Chen, Shi, Zhang, Chi, Rhodes, Steven D, Clapp, D Wade

“…Neurofibromatosis type 1 (NF1) is a common cancer predisposition syndrome caused by mutations in the tumor suppressor gene. encodes neurofibromin, a…”
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New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types by Gampala, Silpa, Moon, Hye-ran, Wireman, Randall, Peil, Jacqueline, Kiran, Sonia, Mitchell, Dana K., Brewster, Kylee, Mang, Henry, Masters, Andi, Bach, Christine, Smith-Kinnamen, Whitney, Doud, Emma H., Rai, Ratan, Mosley, Amber L., Quinney, Sara K., Clapp, D. Wade, Hamdouchi, Chafiq, Wikel, James, Zhang, Chi, Han, Bumsoo, Georgiadis, Millie M., Kelley, Mark R., Fishel, Melissa L.

“…AP endonuclease-1/Redox factor-1 (APE1/Ref-1 or Ref-1) is a multifunctional protein that is overexpressed in most aggressive cancers and impacts various cancer…”
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A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation by Gehlhausen, Jeffrey R, Park, Su-Jung, Hickox, Ann E, Shew, Matthew, Staser, Karl, Rhodes, Steven D, Menon, Keshav, Lajiness, Jacquelyn D, Mwanthi, Muithi, Yang, Xianlin, Yuan, Jin, Territo, Paul, Hutchins, Gary, Nalepa, Grzegorz, Yang, Feng-Chun, Conway, Simon J, Heinz, Michael G, Stemmer-Rachamimov, Anat, Yates, Charles W, Wade Clapp, D

“…Neurofibromatosis type 2 (NF2) is an autosomal dominant genetic disorder resulting from germline mutations in the NF2 gene. Bilateral vestibular schwannomas,…”
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Fanconi anemia signaling network regulates the spindle assembly checkpoint by Nalepa, Grzegorz, Enzor, Rikki, Sun, Zejin, Marchal, Christophe, Park, Su-Jung, Yang, Yanzhu, Tedeschi, Laura, Kelich, Stephanie, Hanenberg, Helmut, Clapp, D Wade

“…Fanconi anemia (FA) is a heterogenous genetic disease with a high risk of cancer. The FA proteins are essential for interphase DNA damage repair; however, it…”
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p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics by Allen, Jayme D., Jaffer, Zahara M., Park, Su-Jung, Burgin, Sarah, Hofmann, Clemens, Sells, Mary Ann, Chen, Shi, Derr-Yellin, Ethel, Michels, Elizabeth G., McDaniel, Andrew, Bessler, Waylan K., Ingram, David A., Atkinson, Simon J., Travers, Jeffrey B., Chernoff, Jonathan, Clapp, D. Wade

“…Mast cells are key participants in allergic diseases via activation of high-affinity IgE receptors (FcϵRI) resulting in release of proinflammatory mediators…”
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