Search Results - "CLAPERON, Audrey"

Epithelial-mesenchymal transition in cholangiocarcinoma: From clinical evidence to regulatory networks by Vaquero, Javier, Guedj, Nathalie, Clapéron, Audrey, Nguyen Ho-Bouldoires, Thanh Huong, Paradis, Valérie, Fouassier, Laura

“…Summary Cholangiocarcinoma (CCA) is an aggressive tumor with a poor prognosis due to its late clinical presentation and the lack of effective non-surgical…”
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The IGF2/IR/IGF1R Pathway in Tumor Cells and Myofibroblasts Mediates Resistance to EGFR Inhibition in Cholangiocarcinoma by Vaquero, Javier, Lobe, Cindy, Tahraoui, Sylvana, Clapéron, Audrey, Mergey, Martine, Merabtene, Fatiha, Wendum, Dominique, Coulouarn, Cédric, Housset, Chantal, Desbois-Mouthon, Christèle, Praz, Françoise, Fouassier, Laura

“…Cholangiocarcinoma (CCA) is a desmoplastic tumor of the biliary tree in which epidermal growth factor receptor (EGFR) is overexpressed and contributes to…”
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EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition by Clapéron, Audrey, Mergey, Martine, Nguyen Ho-Bouldoires, Thanh Huong, Vignjevic, Danijela, Wendum, Dominique, Chrétien, Yves, Merabtene, Fatiha, Frazao, Alexandra, Paradis, Valérie, Housset, Chantal, Guedj, Nathalie, Fouassier, Laura

“…Background & Aims Epithelial-mesenchymal transition (EMT) is a cellular process involved in cancer progression. The first step of EMT consists in the…”
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Mitogenic Insulin Receptor-A Is Overexpressed in Human Hepatocellular Carcinoma due to EGFR-Mediated Dysregulation of RNA Splicing Factors by CHETTOUH, Hamza, FARTOUX, Laetitia, PRAZ, Françoise, HOUSSET, Chantal, ROSMORDUC, Olivier, DESBOIS-MOUTHON, Christèle, AOUDJEHANE, Lynda, WENDUM, Dominique, CLAPERON, Audrey, CHRÉTIEN, Yves, REY, Colette, SCATTON, Olivier, SOUBRANE, Olivier, CONTI, Filomena

“…Insulin receptor (IR) exists as two isoforms resulting from the alternative splicing of IR pre-mRNA. IR-B promotes the metabolic effects of insulin, whereas…”
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Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia by Moujalled, Donia M., Pomilio, Giovanna, Ghiurau, Corina, Ivey, Adam, Salmon, Jessica, Rijal, Sewa, Macraild, Sarah, Zhang, Lan, Teh, Tse-Chieh, Tiong, Ing-Soo, Lan, Ping, Chanrion, Maia, Claperon, Audrey, Rocchetti, Francesca, Zichi, Adrien, Kraus-Berthier, Laurence, Wang, Youzhen, Halilovic, Ensar, Morris, Erick, Colland, Frédéric, Segal, David, Huang, David, Roberts, Andrew W., Maragno, Ana Leticia, Lessene, Guillaume, Geneste, Olivier, Wei, Andrew H.

“…Improving outcomes in acute myeloid leukemia (AML) remains a major clinical challenge. Overexpression of pro-survival BCL-2 family members rendering…”
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Hepatic myofibroblasts promote the progression of human cholangiocarcinoma through activation of epidermal growth factor receptor by Clapéron, Audrey, Mergey, Martine, Aoudjehane, Lynda, Ho‐Bouldoires, Thanh Huong Nguyen, Wendum, Dominique, Prignon, Aurélie, Merabtene, Fatiha, Firrincieli, Delphine, Desbois‐Mouthon, Christèle, Scatton, Olivier, Conti, Filomena, Housset, Chantal, Fouassier, Laura

“…Intrahepatic cholangiocarcinoma (CCA) is characterized by an abundant desmoplastic environment. Poor prognosis of CCA has been associated with the presence of…”
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Loss of ezrin in human intrahepatic cholangiocarcinoma is associated with ectopic expression of E-cadherin by Guedj, Nathalie, Vaquero, Javier, Clapéron, Audrey, Mergey, Martine, Chrétien, Yves, Paradis, Valérie, Fouassier, Laura

“…Aims Ezrin connects proteins from the plasma membrane to the subcortical cytoskeleton, and contributes to epithelial integrity by interacting with the…”
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Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells by Nguyen Ho-Bouldoires, Thanh Huong, Clapéron, Audrey, Mergey, Martine, Wendum, Dominique, Desbois-Mouthon, Christèle, Tahraoui, Sylvana, Fartoux, Laetitia, Chettouh, Hamza, Merabtene, Fatiha, Scatton, Olivier, Gaestel, Matthias, Praz, Françoise, Housset, Chantal, Fouassier, Laura

“…The development and progression of liver cancer are characterized by increased levels of reactive oxygen species (ROS). ROS-induced oxidative stress impairs…”
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Roles of the scaffolding proteins NHERF in liver biology by Clapéron, Audrey, Mergey, Martine, Fouassier, Laura

“…Summary Scaffold proteins are defined by the presence of specific protein-binding domains (e.g. PDZ domains) that assemble several proteins into functional…”
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Ezrin-Radixin-Moesin-Binding Phosphoprotein (EBP50), an Estrogen-Inducible Scaffold Protein, Contributes to Biliary Epithelial Cell Proliferation by Fouassier, Laura, Rosenberg, Peter, Mergey, Martine, Saubaméa, Bruno, Clapéron, Audrey, Kinnman, Nils, Chignard, Nicolas, Jacobsson-Ekman, Gunilla, Strandvik, Birgitta, Rey, Colette, Barbu, Véronique, Hultcrantz, Rolf, Housset, Chantal

“…Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) anchors and regulates apical membrane proteins in epithelia. EBP50 is inducible by estrogen and may…”
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Immunohistochemical profile of ezrin and radixin in human liver epithelia during fetal development and pediatric cholestatic diseases by Clapéron, Audrey, Debray, Dominique, Redon, Marie-José, Mergey, Martine, Nguyen Ho-Bouldoires, Thanh Huong, Housset, Chantal, Fabre, Monique, Fouassier, Laura

“…Summary Aim Ezrin and radixin are actin-binding proteins that contribute to the integrity of epithelia. Abnormalities of bile secretion occur primarily in…”
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The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system by Clapéron, Audrey, Hattab, Claude, Armand, Vincent, Trottier, Suzanne, Bertrand, Olivier, Ouimet, Tanja

“…Abstract The Kell blood group is constituted by two covalently linked antigens at the surface of red blood cells, Kell and Kx. Whereas Kell is a…”
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The Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell protein by Clapéron, Audrey, Rose, Christiane, Gane, Pierre, Collec, Emmanuel, Bertrand, Olivier, Ouimet, Tanja

“…The Kell blood group is a highly polymorphic system containing over 20 different antigens borne by the protein Kell, a 93-kDa type II glycoprotein that…”
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Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure by Fernández-Sánchez, María Elena, Barbier, Sandrine, Whitehead, Joanne, Béalle, Gaëlle, Michel, Aude, Latorre-Ossa, Heldmuth, Rey, Colette, Fouassier, Laura, Claperon, Audrey, Brullé, Laura, Girard, Elodie, Servant, Nicolas, Rio-Frio, Thomas, Marie, Hélène, Lesieur, Sylviane, Housset, Chantal, Gennisson, Jean-Luc, Tanter, Mickaël, Ménager, Christine, Fre, Silvia, Robine, Sylvie, Farge, Emmanuel

“…Magnetically induced mechanical strain mimicking the pressure exerted by a growing tumour in the mouse colon is shown to activate the tumorigenic β-catenin…”
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Mechanical induction of the tumorigenic b-catenin pathway by tumour growth pressure by Fernandez-Sanchez, Maria Elena, Barbier, Sandrine, Whitehead, Joanne, Bealle, Gaelle, Michel, Aude, Latorre-Ossa, Heldmuth, Rey, Colette, Fouassier, Laura, Claperon, Audrey, Brullé, Laura, Girard, Elodie, Servant, Nicolas, Rio-Frio, Thomas, Marie, Helene, Lesieur, Sylviane, Housset, Chantal, Gennisson, Jean-Luc, Tanter, Mickaël, Menager, Christine, Fre, Silvia, Robine, Sylvie, Farge, Emmanuel

“…The tumour microenvironment may contribute to tumorigenesis owing to mechanical forces such as fibrotic stiffness or mechanical pressure caused by the…”
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Discovery of S64315, a Potent and Selective Mcl‑1 Inhibitor by Szlavik, Zoltan, Csekei, Marton, Paczal, Attila, Szabo, Zoltan B, Sipos, Szabolcs, Radics, Gabor, Proszenyak, Agnes, Balint, Balazs, Murray, James, Davidson, James, Chen, Ijen, Dokurno, Pawel, Surgenor, Allan E, Daniels, Zoe Marie, Hubbard, Roderick E, Le Toumelin-Braizat, Gaëtane, Claperon, Audrey, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Bruno, Alain, Chanrion, Maia, Colland, Frédéric, Maragno, Ana-Leticia, Demarles, Didier, Geneste, Olivier, Kotschy, Andras

“…Myeloid cell leukemia 1 (Mcl-1) has emerged as an attractive target for cancer therapy. It is an antiapoptotic member of the Bcl-2 family of proteins, whose…”
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Structure-Guided Discovery of a Selective Mcl‑1 Inhibitor with Cellular Activity by Szlávik, Zoltan, Ondi, Levente, Csékei, Márton, Paczal, Attila, Szabó, Zoltán B, Radics, Gábor, Murray, James, Davidson, James, Chen, Ijen, Davis, Ben, Hubbard, Roderick E, Pedder, Christopher, Dokurno, Pawel, Surgenor, Allan, Smith, Julia, Robertson, Alan, LeToumelin-Braizat, Gaetane, Cauquil, Nicolas, Zarka, Marion, Demarles, Didier, Perron-Sierra, Francoise, Claperon, Audrey, Colland, Frederic, Geneste, Olivier, Kotschy, András

“…Myeloid cell leukemia 1 (Mcl-1), an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation when observed in human cancers is associated with…”
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S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth by Casara, Patrick, Davidson, James, Claperon, Audrey, Le Toumelin-Braizat, Gaëtane, Vogler, Meike, Bruno, Alain, Chanrion, Maïa, Lysiak-Auvity, Gaëlle, Le Diguarher, Thierry, Starck, Jérôme-Benoît, Chen, Ijen, Whitehead, Neil, Graham, Christopher, Matassova, Natalia, Dokurno, Pawel, Pedder, Christopher, Wang, Youzhen, Qiu, Shumei, Girard, Anne-Marie, Schneider, Emilie, Gravé, Fabienne, Studeny, Aurélie, Guasconi, Ghislaine, Rocchetti, Francesca, Maïga, Sophie, Henlin, Jean-Michel, Colland, Frédéric, Kraus-Berthier, Laurence, Le Gouill, Steven, Dyer, Martin J S, Hubbard, Roderick, Wood, Mike, Amiot, Martine, Cohen, Gerald M, Hickman, John A, Morris, Erick, Murray, James, Geneste, Olivier

“…Escape from apoptosis is one of the major hallmarks of cancer cells. The B-cell Lymphoma 2 (BCL-2) gene family encodes pro-apoptotic and anti-apoptotic…”
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Abstract 257: Targeting AML through apoptosis activation using Bcl-2/Mcl-1 or Bcl-2/Hdm2 inhibitor combination therapies by Wang, Youzhen, Qui, Shumei, Sanghavi, Sneha, Mulford, Iain, Lysiak, Gaëlle, Chanrion, Maïa, Mistry, Prakash, Pfaar, Ulrike, Schoumacher, Marie, Claperon, Audrey, Kraus-Berthier, Laurence, Banquet, Sébastien, Derreal, Alix, Fabre, Claire, Maacke, Heiko, Colland, Frédéric, Geneste, Olivier, Morris, Erick, Halilovic, Ensar

“…Abstract Acute myeloid leukemia (AML) is an aggressive and heterogeneous hematologic malignancy, characterized by uncontrolled proliferation and impaired…”
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Abstract 1276: Identification of S65487/VOB560 as a potent and selective intravenous 2nd-generation BCL-2 inhibitor active in wild-type and clinical mutants resistant to Venetoclax by Tiran, Arnaud Le, Claperon, Audrey, Davidson, James, Starck, Jérôme-Benoit, Diguarher, Thierry Le, Chanrion, Maïa, Mistry, Prakash, Wang, Youzhen, Monceau, Elodie, Bernhardt, Fabienne, Rocchetti, Francesca, Lysiak-Auvity, Gaelle, Chen, Ijen, Daniels, Zoe, Pedder, Chris, Fallowfield, Mandy, Henlin, Jean-Michel, Fejes, Imre, Tatai, Janos, Nyerges, Miklos, Durand, Didier, Zarka, Marion, Sanghavi, Sneha, Girard, Anne-Marie, Schoumacher, Marie, Kraus-Berthier, Laurence, Newcombe, Rick, Halilovic, Ensar, Banquet, Sébastien, Rupin, Alain, Maacke, Heiko, Murray, James, Morris, Erick, Hofmann, Francesco, Colland, Frédéric, Geneste, Olivier

“…Abstract The B-cell Lymphoma 2 (BCL-2) gene family encodes pro-apoptotic and anti-apoptotic proteins that are key regulators of the apoptotic process…”
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