Search Results - "CLACK, G"

A platform for brain-wide imaging and reconstruction of individual neurons by Economo, Michael N, Clack, Nathan G, Lavis, Luke D, Gerfen, Charles R, Svoboda, Karel, Myers, Eugene W, Chandrashekar, Jayaram

“…The structure of axonal arbors controls how signals from individual neurons are routed within the mammalian brain. However, the arbors of very few long-range…”
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Vibrissa-Based Object Localization in Head-Fixed Mice by O'Connor, Daniel H, Clack, Nathan G, Huber, Daniel, Komiyama, Takaki, Myers, Eugene W, Svoboda, Karel

“…Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments in genetic model systems such as…”
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A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker by Khoja, L, Backen, A, Sloane, R, Menasce, L, Ryder, D, Krebs, M, Board, R, Clack, G, Hughes, A, Blackhall, F, Valle, J W, Dive, C

“…Background: Obtaining tissue for pancreatic carcinoma diagnosis and biomarker assessment to aid drug development is challenging. Circulating tumour cells…”
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Assessment of various continual reassessment method models for dose-escalation phase 1 oncology clinical trials: using real clinical data and simulation studies by James, G D, Symeonides, S, Marshall, J, Young, J, Clack, G

“…The continual reassessment method (CRM) identifies the maximum tolerated dose (MTD) more efficiently and identifies the true MTD more frequently compared to…”
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The mechanical variables underlying object localization along the axis of the whisker by Pammer, Lorenz, O'Connor, Daniel H, Hires, S Andrew, Clack, Nathan G, Huber, Daniel, Myers, Eugene W, Svoboda, Karel

“…Rodents move their whiskers to locate objects in space. Here we used psychophysical methods to show that head-fixed mice can localize objects along the axis of…”
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Automated tracking of whiskers in videos of head fixed rodents by Clack, Nathan G, O'Connor, Daniel H, Huber, Daniel, Petreanu, Leopoldo, Hires, Andrew, Peron, Simon, Svoboda, Karel, Myers, Eugene W

“…We have developed software for fully automated tracking of vibrissae (whiskers) in high-speed videos (>500 Hz) of head-fixed, behaving rodents trimmed to a…”
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Long-term effects of anastrozole on bone mineral density: 7-year results from the ATAC trial by Eastell, R., Adams, J., Clack, G., Howell, A., Cuzick, J., Mackey, J., Beckmann, M.W., Coleman, R.E.

“…This ‘Arimidex’, Tamoxifen, Alone or in Combination (ATAC) trial sub-study examined the effects of anastrozole and tamoxifen on bone mineral density (BMD)…”
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PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours by Dillon, M.T., Boylan, Z., Smith, D., Guevara, J., Mohammed, K., Peckitt, C., Saunders, M., Banerji, U., Clack, G., Smith, S.A., Spicer, J.F., Forster, M.D., Harrington, K.J.

“…•Summary of a protocol for a phase I study combining the ATR inhibitor and palliative radiotherapy.•Study design is discussed.•Study aims and objectives, brief…”
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Circulating melanoma cells and survival in metastatic melanoma by RAO, C, BUI, T, CONNELLY, M, DOYLE, G, KARYDIS, I, MIDDLETON, M. R, CLACK, G, MALONE, M, COUMANS, F. A. W, TERSTAPPEN, L. W. M. M

“…A validated assay for the enumeration of circulating melanoma cells (CMCs) may facilitate the development of more effective therapies for metastatic melanoma…”
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AZD3514, an oral selective androgen receptor down-regulator in patients with castration-resistant prostate cancer – results of two parallel first-in-human phase I studies by Omlin, A., Jones, R. J., van der Noll, R., Satoh, T., Niwakawa, M., Smith, S. A., Graham, J., Ong, M., Finkelman, R. D., Schellens, J. H. M., Zivi, A., Crespo, M., Riisnaes, R., Nava-Rodrigues, D., Malone, M. D., Dive, C., Sloane, R., Moore, D., Alumkal, J. J., Dymond, A., Dickinson, P. A., Ranson, M., Clack, G., de Bono, J., Elliott, T.

“…Summary Background AZD3514 is a first-in-class, orally bio-available, androgen-dependent and -independent androgen receptor inhibitor and selective…”
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Assessment of diurnal changes and confounding factors that affect circulating cell death biomarker levels: A short communication by Greystoke, A., Harris, G., Jenkins, M., Goonetilleke, D., Moore, D., Lancashire, M., Ranson, M., Hughes, A., Clack, G., Dive, C.

“…Minimal variability was seen in levels of cleaved and total cytokeratin 18 throughout a 4 week period with 2 periods of intensive 24h sampling. However,…”
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A Prototypical Process for Creating Evidentiary Standards for Biomarkers and Diagnostics by Altar, CA, Amakye, D, Bounos, D, Bloom, J, Clack, G, Dean, R, Devanarayan, V, Fu, D, Furlong, S, Hinman, L, Girman, C, Lathia, C, Lesko, L, Madani, S, Mayne, J, Meyer, J, Raunig, D, Sager, P, Williams, SA, Wong, P, Zerba, K

“…A framework for developing evidentiary standards for qualification of biomarkers is a key need identified in the Food and Drug Administration's Critical Path…”
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The ATAC (‘Arimidex’, Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: first results of the endometrial sub-protocol following 2 years of treatment by Duffy, S., Jackson, T.L., Lansdown, M., Philips, K., Wells, M., Pollard, S., Clack, G., Coibion, M., Bianco, A.R.

“…BACKGROUND: Tamoxifen treatment results in a doubling of the risk of endometrial cancer after 1–2 years of treatment and a quadrupling after 5 years…”
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Systems Pharmacology Modeling of Prostate‐Specific Antigen in Patients With Prostate Cancer Treated With an Androgen Receptor Antagonist and Down‐Regulator by Mistry, HB, Fabre, M‐A, Young, J, Clack, G, Dickinson, PA

“…First‐in‐human (FIH) studies with AZD3514, a selective androgen receptor (AR) down‐regulator, showed decreases of >30% in the prostate‐specific antigen (PSA)…”
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Current status and future potential of somatic mutation testing from circulating free DNA in patients with solid tumours by Aung, K. L., Board, R. E., Ellison, G., Donald, E., Ward, T., Clack, G., Ranson, M., Hughes, A., Newman, W., Dive, C.

“…Genetic alterations can determine the natural history of cancer and its treatment response. With further advances in DNA sequencing technology, multiple novel…”
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Src inhibitors in early breast cancer: a methodology, feasibility and variability study by Jones, R. J, Young, O, Renshaw, L, Jacobs, V, Fennell, M, Marshall, A, Green, T. P, Elvin, P, Womack, C, Clack, G, Dixon, J. M

“…Early clinical trials of anticancer agents may be enriched by robust biomarkers of activity. Surrogate measures used in trials of cytotoxic agents, such as…”
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The ATAC adjuvant breast-cancer trial: Six-year results of the endometrial subprotocol by Duffy, S., Jackson, T. L., Lansdown, M., Philips, K., Wells, M., Clack, G., Bianco, A. R.

“…Postmenopausal women with localised, early breast cancer (n = 285) were enrolled in a prospective subprotocol of the 'arimidex, tamoxifen, alone or in…”
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Medical graduates evaluate the effectiveness of their education by Clack, G B

“…In response to the General Medical Council's 1991 Consultative Document proposing changes to medical curricula, the King's College School of Medicine and…”
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Many-Particle Tracking with Nanometer Resolution in Three Dimensions by Reflection Interference Contrast Microscopy by Clack, Nathan G, Groves, Jay T

“…We have developed and characterized a method, based on reflection interference contrast microscopy, to simultaneously determine the three-dimensional positions…”
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Electrostatic readout of DNA microarrays with charged microspheres by Groves, Jay T, Clack, Nathan G, Salaita, Khalid

“…DNA microarrays are used for gene-expression profiling, single-nucleotide polymorphism detection and disease diagnosis. A persistent challenge in this area is…”
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