Estrogen enhances wound healing in the penis of rats

Estrogen receptor (ER) α and β and aromatase are expressed in various cell-types and compartments of the penis, including the epidermis of glans penis. Here, we hypothesize that estrogen helps maintain the viability and integrity of glans penis and test the hypothesis by treating lesioned glans peni...

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Bibliographic Details
Published in:	Biomedical Research Vol. 29; no. 5; pp. 267 - 270
Main Authors:	CN, Mowa, R, Hoch, CL, Montavon, S, Jesmin, G, Hindman, G, Hou
Format:	Journal Article
Language:	English
Published:	Japan Biomedical Research Press 2008 Japan Science and Technology Agency
Subjects:	Animals Castration Estradiol - pharmacology Estrogens - pharmacology Humans Male Penis - anatomy & histology Penis - drug effects Penis - pathology Rats Rats, Sprague-Dawley Vascular Endothelial Growth Factor A - metabolism Wound Healing - drug effects
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Summary:	Estrogen receptor (ER) α and β and aromatase are expressed in various cell-types and compartments of the penis, including the epidermis of glans penis. Here, we hypothesize that estrogen helps maintain the viability and integrity of glans penis and test the hypothesis by treating lesioned glans penis with either 17β-estradiol or vehicle only. Estrogen was found to facilitate wound healing and increase vascular endothelial growth factor (VEGF) immunoreactivity compared to control, as revealed by scanning electron microscopy, histology, and immunohistochemistry. We conclude that estrogen plays a role in maintaining glans penis integrity, in part, by facilitating penile healing, possibly via up-regulating VEGF levels.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0388-6107 1880-313X
DOI:	10.2220/biomedres.29.267