Search Results - "CIRILLO, Pier F"

Selective CB2 receptor agonists. Part 1: The identification of novel ligands through computer-aided drug design (CADD) approaches by Hickey, Eugene R., Zindell, Renee, Cirillo, Pier F., Wu, Lifen, Ermann, Monika, Berry, Angela K., Thomson, David S., Albrecht, Claudia, Gemkow, Mark J., Riether, Doris

“…[Display omitted] Computer-aided drug design scaffold hopping strategies were utilized to identify new classes of CB2 agonists when compounds of an established…”
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Green Fischer Indole Synthesis Using a Steroidal Ketone in a Conductively Heated Sealed-Vessel Reactor for the Advanced Undergraduate Laboratory by Cirillo, Pier F, Caccavale, Alexis, DeLuna, Alicia

“…Highly efficient microwave-assisted organic synthesis is now commonplace in both industry and academia. Recently, a conductively heated sealed-vessel reactor…”
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Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site by Pargellis, Christopher, Tong, Liang, Churchill, Laurie, Cirillo, Pier F, Gilmore, Thomas, Graham, Anne G, Grob, Peter M, Hickey, Eugene R, Moss, Neil, Pav, Susan, Regan, John

“…The p38 MAP kinase plays a crucial role in regulating the production of proinflammatory cytokines, such as tumor necrosis factor and interleukin-1. Blocking…”
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Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders by Cirillo, Pier F, Asojo, Oluwatoyin A, Khire, Uday, Lee, Yashang, Mootien, Sara, Hegan, Peter, Sutherland, Alan G, Peterson-Roth, Elizabeth, Ledizet, Michel, Koski, Raymond A, Anthony, Karen G

“…Human Macrophage Migration Inhibitory Factor (MIF) is a trimeric cytokine implicated in a number of inflammatory and autoimmune diseases and cancer. We…”
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Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796) by Regan, John, Capolino, Alison, Cirillo, Pier F, Gilmore, Thomas, Graham, Anne G, Hickey, Eugene, Kroe, Rachel R, Madwed, Jeffrey, Moriak, Monica, Nelson, Richard, Pargellis, Christopher A, Swinamer, Alan, Torcellini, Carol, Tsang, Michele, Moss, Neil

“…We report on the structure−activity relationships (SAR) of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea (BIRB…”
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The non-diaryl heterocycle classes of p38 MAP kinase inhibitors by Cirillo, Pier F, Pargellis, Christopher, Regan, John

“…The p38 mitogen activated protein (MAP) kinase is an integral enzyme involved in the production of a wide variety of pro-inflammatory cytokines from various…”
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1,4-Diazepane compounds as potent and selective CB2 agonists: Optimization of metabolic stability by Riether, Doris, Wu, Lifen, Cirillo, Pier F., Berry, Angela, Walker, Edward R., Ermann, Monika, Noya-Marino, Beatriz, Jenkins, James E., Albaugh, Dan, Albrecht, Claudia, Fisher, Michael, Gemkow, Mark J., Grbic, Heather, Löbbe, Sabine, Möller, Clemens, O’Shea, Kathy, Sauer, Achim, Shih, Daw-Tsun, Thomson, David S.

“…A high-throughput screening campaign has identified 1,4-diazepane compounds which are potent Cannabinoid receptor 2 agonists with excellent selectivity against…”
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Studies Directed toward the Synthesis of (+)-Sesbanimide A: Construction of the AB-Ring System (A Formal Total Synthesis) by Cirillo, Pier F, Panek, James S

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New modifications to the area of pyrazole-naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site by Moss, Neil, Breitfelder, Steffen, Betageri, Raj, Cirillo, Pier F., Fadra, Tazmeen, Hickey, Eugene R., Kirrane, Thomas, Kroe, Rachel R., Madwed, Jeffrey, Nelson, Richard M., Pargellis, Christopher A., Qian, Kevin C., Regan, John, Swinamer, Alan, Torcellini, Carol

“…Discovery of the pyrazole-naphthyl urea class of p38 MAP kinase inhibitors typified by the clinical candidate BIRB 796 has encouraged further exploration of…”
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Discovery and characterization of the N-phenyl- N′-naphthylurea class of p38 kinase inhibitors by Cirillo, Pier F., Hickey, Eugene R., Moss, Neil, Breitfelder, Steffen, Betageri, Raj, Fadra, Tazmeen, Gaenzler, Faith, Gilmore, Thomas, Goldberg, Daniel R., Kamhi, Victor, Kirrane, Thomas, Kroe, Rachel R., Madwed, Jeffrey, Moriak, Monica, Netherton, Matthew, Pargellis, Christopher A., Patel, Usha R., Qian, Kevin C., Sharma, Rajiv, Sun, Sanxing, Swinamer, Alan, Torcellini, Carol, Takahashi, Hidenori, Tsang, Michele, Xiong, Zhaoming

“…An effort aimed at exploring structural diversity in the N-pyrazole- N′-naphthylurea class of p38 kinase inhibitors led to the synthesis and characterization…”
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Diastereoselectivity in nucleophilic addition reactions to (.alpha.,.beta.-dialkoxyacyl) silanes: an operationally useful route to optically active 1,2,3-syn-triols by Cirillo, Pier F, Panek, James S

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pi.-Facial selectivity in catalytic osmylation reactions of chiral C1-oxygenated allylic silanes by Panek, James S, Cirillo, Pier F

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The kinetics of binding to p38MAP kinase by analogues of BIRB 796 by Regan, John, Pargellis, Christopher A, Cirillo, Pier F, Gilmore, Thomas, Hickey, Eugene R, Peet, Gregory W, Proto, Alfred, Swinamer, Alan, Moss, Neil

“…BIRB 796, a member of the N-pyrazole-N'-naphthly urea class of p38MAPK inhibitors, binds to the kinase with both slow association and dissociation rates. Prior…”
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Acyclic diastereoselectivity in the Lewis acid promoted additions of chiral, .beta.-methyl-substituted (E)-crotylsilanes with achiral aldehydes by Panek, James S, Cirillo, Pier F

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The kinetics of binding to p38 MAP kinase by analogues of BIRB 796 by Regan, John, Pargellis, Christopher A., Cirillo, Pier F., Gilmore, Thomas, Hickey, Eugene R., Peet, Gregory W., Proto, Alfred, Swinamer, Alan, Moss, Neil

“…BIRB 796, a member of the N-pyrazole- N′-naphthly urea class of p38 MAPK inhibitors, binds to the kinase with both slow association and dissociation rates…”
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The kinetics of binding to p38 MAP kinase by analogues of BIRB 796: Recent advances in the design of kinase inhibitors as novel therapeutic agents by REGAN, John, PARGELLIS, Christopher A, CIRILLO, Pier F, GILMORE, Thomas, HICKEY, Eugene R, PEET, Gregory W, PROTO, Alfred, SWINAMER, Alan, MOSS, Neil

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Structure-activity relationships of the p38a MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphtha len-1-yl]urea (BIRB 796) by REGAN, John, CAPOLINO, Alison, PARGELLIS, Christopher A, SWINAMER, Alan, TORCELLINI, Carol, TSANG, Michele, MOSS, Neil, CIRILLO, Pier F, GILMORE, Thomas, GRAHAM, Anne G, HICKEY, Eugene, KROE, Rachel R, MADWED, Jeffrey, MORIAK, Monica, NELSON, Richard

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Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796) by Regan, John, Capolino, Alison, Cirillo, Pier F, Gilmore, Thomas, Graham, Anne G, Hickey, Eugene, Kroe, Rachel R, Madwed, Jeffrey, Moriak, Monica, Nelson, Richard, Pargellis, Christopher A, Swinamer, Alan, Torcellini, Carol, Tsang, Michele, Moss, Neil

“…We report on the structure-activity relationships (SAR) of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea (BIRB…”
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An efficient procedure for the preparation of chiral β-substituted ( E)-crotylsilanes: Application of a rhodium(II) catalyzed silylformylation of terminal alkynes by Jain, Nareshkumar F., Cirillo, Pier F., Schaus, Jennifer V., Panek, James S.

“…Functionalized β-substituted ( E)-crotylsilanes ( R)-7 and ( S)-8, bearing an alkyl or aryl group adjacent to the stereogenic C-Si center have been synthesized…”
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Double stereodifferentiation in the lewis acid promoted crotylation of ( S)-2-Alkoxypropanal with chiral β-Alkyl ( E)-Crotylsilanes by Jain, Nareshkumar F., Cirillo, Pier F., Pelletier, Roberta, Panek, James S.

“…The sense and level of 1,2-asymmetric induction have been evaluated in the Lewis acid promoted addition of ( E)crotylsilanes ( S)-1 and ( R)-2 to (…”
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