High and low grade oligodendrogliomas (ODG): correlation of amino-acid and glucose uptakes using PET and histological classifications

Classification and treatment strategy of oligodendrogliomas (ODG) remain controversial. Imaging relies essentially on contrast enhancement using CT or MRI. The aim of our study was to use positron emission tomography (PET) using [18F]-flurodeoxyglucose (FDG) and [11C]-L-methyl-methionine (MET) to ev...

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Bibliographic Details
Published in:	Journal of neuro-oncology Vol. 68; no. 3; pp. 263 - 274
Main Authors:	GIAMMARILE, F, CINOTTI, L. E, HONNORAT, J, LE BARS, D, FRAPPAZ, D, JOUVET, A, RAMACKERS, J. M, PIERRE, G. Saint, THIESSE, P, JOUANNEAU, E, GUYOTAT, J, PELISSOU-GUYOTAT, I, SETIEY, A
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer 01-07-2004 Springer Nature B.V
Subjects:	Adult Amino Acids - pharmacokinetics Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Brain Neoplasms - classification Brain Neoplasms - diagnostic imaging Brain Neoplasms - metabolism Brain Neoplasms - pathology Carbon Isotopes - pharmacokinetics Female Fluorodeoxyglucose F18 - pharmacokinetics Glucose - metabolism Humans Magnetic Resonance Imaging Male Medical sciences Methionine - analogs & derivatives Methionine - pharmacokinetics Middle Aged Neurology Oligodendroglioma - classification Oligodendroglioma - diagnostic imaging Oligodendroglioma - metabolism Oligodendroglioma - pathology Radiopharmaceuticals - pharmacokinetics Tomography, Emission-Computed Radionuclide study Nervous system diseases C11-methionine Malignant tumor Glucose histopathological classification Uptake Oligodendroglioma Malignant glioma Central nervous system disease Classification positron emission tomography F18-fluorodeoxyglucose Positron Emission tomography
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Summary:	Classification and treatment strategy of oligodendrogliomas (ODG) remain controversial. Imaging relies essentially on contrast enhancement using CT or MRI. The aim of our study was to use positron emission tomography (PET) using [18F]-flurodeoxyglucose (FDG) and [11C]-L-methyl-methionine (MET) to evaluate metabolic characteristics of ODG. We studied 19 patients with proven ODG, comparing standardized uptake values (SUV) and maximal tumor/contralateral normal tissues ratios (T/N). Imaging findings were compared with WHO, Smith and Daumas-Duport classifications. Uptake of FDG was decreased only in 8 patients, independently of grading, while MET uptake was always increased. MET uptake was significantly higher for high grade tumors grouped according to Smith or Daumas-Duport classifications, while no significant difference in MET uptake was found when using WHO classification. A different correlation was found between FDG and MET uptakes in normal tissues and high grade tumors. A trend for improved progression free survival was found for tumors that lacked contrast enhancement on MRI or those showing low FDG or MET uptake. In conclusion, MET appeared more sensitive than FDG to detect proliferation in ODG. The preferential protein metabolism, already noticeable for low-grade tumor, correlated with glucose metabolism and helped to separate, in vivo, high and low grade tumors.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0167-594X 1573-7373
DOI:	10.1023/b:neon.0000033384.43417.82