Search Results - "CILLI, Michele"

LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β by Rossi, Martina, Bucci, Gabriele, Rizzotto, Dario, Bordo, Domenico, Marzi, Matteo J., Puppo, Margherita, Flinois, Arielle, Spadaro, Domenica, Citi, Sandra, Emionite, Laura, Cilli, Michele, Nicassio, Francesco, Inga, Alberto, Briata, Paola, Gherzi, Roberto

“…Long noncoding RNAs (lncRNAs) are emerging as regulators of fundamental biological processes. Here we report on the characterization of an intergenic lncRNA…”
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Amniotic liquid derived stem cells as reservoir of secreted angiogenic factors capable of stimulating neo-arteriogenesis in an ischemic model by Mirabella, Teodelinda, Cilli, Michele, Carlone, Sebastiano, Cancedda, Ranieri, Gentili, Chiara

“…Abstract Most urgent health problems are related to a blood vessel formation failure. The use of stem cells from different sources or species for both in vitro…”
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Bevacizumab-mediated tumor vasculature remodelling improves tumor infiltration and antitumor efficacy of GD2-CAR T cells in a human neuroblastoma preclinical model by Bocca, Paola, Di Carlo, Emma, Caruana, Ignazio, Emionite, Laura, Cilli, Michele, De Angelis, Biagio, Quintarelli, Concetta, Pezzolo, Annalisa, Raffaghello, Lizzia, Morandi, Fabio, Locatelli, Franco, Pistoia, Vito, Prigione, Ignazia

“…GD2-redirected chimeric antigen receptor (CAR) T lymphocytes represent a promising therapeutic option for immunotherapy of neuroblastoma (NB). However, despite…”
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Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer by Marini, Cecilia, Salani, Barbara, Massollo, Michela, Amaro, Adriana, Esposito, Alessia Isabella, Maria Orengo, Anna, Capitanio, Selene, Emionite, Laura, Riondato, Mattia, Bottoni, Gianluca, Massara, Cinzia, Boccardo, Simona, Fabbi, Marina, Campi, Cristina, Ravera, Silvia, Angelini, Giovanna, Morbelli, Silvia, Cilli, Michele, Cordera, Renzo, Truini, Mauro, Maggi, Davide, Pfeffer, Ulrich, Sambuceti, Gianmario

“…Emerging evidence suggests that metformin, a widely used anti-diabetic drug, may be useful in the prevention and treatment of different cancers. In the present…”
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Manganese-enhanced MRI (MEMRI) in breast and prostate cancers: Preliminary results exploring the potential role of calcium receptors by Baio, Gabriella, Fabbi, Marina, Cilli, Michele, Rosa, Francesca, Boccardo, Simona, Valdora, Francesca, Salvi, Sandra, Basso, Luca, Emionite, Laura, Gianolio, Eliana, Aime, Silvio, Neumaier, Carlo Emanuele

“…Procedures To preliminary assess the relationship between Manganese Enhanced Magnetic Resonance Imaging (MEMRI) and the expression of calcium receptors in…”
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A High-Content Screening of Anticancer Compounds Suggests the Multiple Tyrosine Kinase Inhibitor Ponatinib for Repurposing in Neuroblastoma Therapy by Sidarovich, Viktoryia, De Mariano, Marilena, Aveic, Sanja, Pancher, Michael, Adami, Valentina, Gatto, Pamela, Pizzini, Silvia, Pasini, Luigi, Croce, Michela, Parodi, Federica, Cimmino, Flora, Avitabile, Marianna, Emionite, Laura, Cilli, Michele, Ferrini, Silvano, Pagano, Aldo, Capasso, Mario, Quattrone, Alessandro, Tonini, Gian Paolo, Longo, Luca

“…Novel druggable targets have been discovered in neuroblastoma (NB), paving the way for more effective treatments. However, children with high-risk NB still…”
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Bone turnover in wild type and pleiotrophin-transgenic mice housed for three months in the International Space Station (ISS) by Tavella, Sara, Ruggiu, Alessandra, Giuliani, Alessandra, Brun, Francesco, Canciani, Barbara, Manescu, Adrian, Marozzi, Katia, Cilli, Michele, Costa, Delfina, Liu, Yi, Piccardi, Federica, Tasso, Roberta, Tromba, Giuliana, Rustichelli, Franco, Cancedda, Ranieri

“…Bone is a complex dynamic tissue undergoing a continuous remodeling process. Gravity is a physical force playing a role in the remodeling and contributing to…”
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Tumor vascular targeted liposomal-bortezomib minimizes side effects and increases therapeutic activity in human neuroblastoma by Zuccari, Guendalina, Milelli, Andrea, Pastorino, Fabio, Loi, Monica, Petretto, Andrea, Parise, Amelia, Marchetti, Chiara, Minarini, Anna, Cilli, Michele, Emionite, Laura, Di Paolo, Daniela, Brignole, Chiara, Piaggio, Francesca, Perri, Patrizia, Tumiatti, Vincenzo, Pistoia, Vito, Pagnan, Gabriella, Ponzoni, Mirco

“…Neuroblastoma is a childhood cancer with poor long-term prognosis in advanced stages. A major aim in neuroblastoma therapy is to develop targeted drug delivery…”
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Oct 4＋/Tenascin C＋ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells by Pezzolo, Annalisa, Parodi, Federica, Marimpietri, Danilo, Raffaghello, Lizzia, Cocco, Claudia, Pistorio, Angela, Mosconi, Manuela, Gambini, Claudio, Cilli, Michele, Deaglio, Silvia, Malavasi, Fabio, Pistoia, Vito

“…Neuroblastoma （NB）-associated endothelial microvesseis （EMs） may be lined by tumor-derived endothelial cells （TECs）, that are genetically unstable and…”
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Enhancement of Tumor Homing by Chemotherapy‐Loaded Nanoparticles by Ponzoni, Mirco, Curnis, Flavio, Brignole, Chiara, Bruno, Silvia, Guarnieri, Daniela, Sitia, Leopoldo, Marotta, Roberto, Sacchi, Angelina, Bauckneht, Matteo, Buschiazzo, Ambra, Rossi, Andrea, Di Paolo, Daniela, Perri, Patrizia, Gori, Alessandro, Sementa, Angela R., Emionite, Laura, Cilli, Michele, Tamma, Roberto, Ribatti, Domenico, Pompa, Pier Paolo, Marini, Cecilia, Sambuceti, Gianmario, Corti, Angelo, Pastorino, Fabio

“…Targeted delivery of anticancer drugs with nanocarriers can reduce side effects and ameliorate therapeutic efficacy. However, poorly perfused and dysfunctional…”
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Cell surface Nucleolin represents a novel cellular target for neuroblastoma therapy by Brignole, Chiara, Bensa, Veronica, Fonseca, Nuno A, Del Zotto, Genny, Bruno, Silvia, Cruz, Ana F, Malaguti, Fabiana, Carlini, Barbara, Morandi, Fabio, Calarco, Enzo, Perri, Patrizia, Moura, Vera, Emionite, Laura, Cilli, Michele, De Leonardis, Francesco, Tondo, Annalisa, Amoroso, Loredana, Conte, Massimo, Garaventa, Alberto, Sementa, Angela R, Corrias, Maria V, Ponzoni, Mirco, Moreira, Joao N, Pastorino, Fabio

“…Neuroblastoma (NB) represents the most frequent and aggressive form of extracranial solid tumor of infants. Nucleolin (NCL) is a protein overexpressed and…”
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Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature- specific ligands potentiates therapeutic efficacy by PASTORINO, Fabio, BRIGNOLE, Chiara, RIBATTI, Domenico, CORTI, Angelo, ALLEN, Theresa M, PONZONI, Mirco, DI PAOLO, Daniela, NICO, Bice, PEZZOLO, Annalisa, MARIMPIETRI, Danilo, PAGNAN, Gabriella, PICCARDI, Federica, CILLI, Michele, LONGHI, Renato

“…Neuroblastoma, the most common solid tumor of infancy derived from the sympathetic nervous system, continues to present a formidable clinical challenge…”
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Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma by Lucarini, Valeria, Melaiu, Ombretta, D’Amico, Silvia, Pastorino, Fabio, Tempora, Patrizia, Scarsella, Marco, Pezzullo, Marco, De Ninno, Adele, D’Oria, Valentina, Cilli, Michele, Emionite, Laura, Infante, Paola, Di Marcotullio, Lucia, De Ioris, Maria Antonietta, Barillari, Giovanni, Alaggio, Rita, Businaro, Luca, Ponzoni, Mirco, Locatelli, Franco, Fruci, Doriana

“…Abstract Background Poor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a…”
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Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation by Tomati, Valeria, Sondo, Elvira, Armirotti, Andrea, Caci, Emanuela, Pesce, Emanuela, Marini, Monica, Gianotti, Ambra, Ju Jeon, Young, Cilli, Michele, Pistorio, Angela, Mastracci, Luca, Ravazzolo, Roberto, Scholte, Bob, Ronai, Ze’ev, Galietta, Luis J. V., Pedemonte, Nicoletta

“…Cystic fibrosis (CF) is caused by mutations in the CFTR chloride channel. Deletion of phenylalanine 508 (F508del), the most frequent CF mutation, impairs CFTR…”
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Enhanced anti-tumor and anti-angiogenic efficacy of a novel liposomal fenretinide on human neuroblastoma by Di Paolo, Daniela, Pastorino, Fabio, Zuccari, Guendalina, Caffa, Irene, Loi, Monica, Marimpietri, Danilo, Brignole, Chiara, Perri, Patrizia, Cilli, Michele, Nico, Beatrice, Ribatti, Domenico, Pistoia, Vito, Ponzoni, Mirco, Pagnan, Gabriella

“…Neuroblastoma is an embryonal tumor originating from the simpatico-adrenal lineage of the neural crest. It approximately accounts for about 15% of all…”
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Tumor Regression and Curability of Preclinical Neuroblastoma Models by PEGylated SN38 (EZN-2208), a Novel Topoisomerase I Inhibitor by PASTORINO, Fabio, LOI, Monica, SAPRA, Puja, BECHERINI, Pamela, CILLI, Michele, EMIONITE, Laura, RIBATTI, Domenico, GREENBERGER, Lee M, HORAK, Ivan D, PONZONI, Mirco

“…Treatment of neuroblastoma is successful in less than half of patients with high-risk disease. The antitumor activity of a water soluble pegylated SN38 drug…”
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The Neuronal Pentraxin-2 Pathway Is an Unrecognized Target in Human Neuroblastoma, Which Also Offers Prognostic Value in Patients by Bartolini, Alice, Di Paolo, Daniela, Noghero, Alessio, Murgia, Daniele, Sementa, Angela R, Cilli, Michele, Pasqualini, Renata, Arap, Wadih, Bussolino, Federico, Ponzoni, Mirco, Pastorino, Fabio, Marchiò, Serena

“…Neuronal pentraxins (NPTX) and their corresponding receptors (NPTXR) have been studied as synapse-associated proteins in the nervous system, but their role in…”
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Antitumor activity of the investigational B7-H3 antibody-drug conjugate, vobramitamab duocarmazine, in preclinical models of neuroblastoma by Brignole, Chiara, Calarco, Enzo, Bensa, Veronica, Giusto, Elena, Perri, Patrizia, Ciampi, Eleonora, Corrias, Maria Valeria, Astigiano, Simonetta, Cilli, Michele, Loo, Derik, Bonvini, Ezio, Pastorino, Fabio, Ponzoni, Mirco

“…Introduction B7-H3 is a potential target for pediatric cancers, including neuroblastoma (NB). Vobramitamab duocarmazine (also referred to as MGC018 and herein…”
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Mda-9/syntenin is expressed in uveal melanoma and correlates with metastatic progression by Gangemi, Rosaria, Mirisola, Valentina, Barisione, Gaia, Fabbi, Marina, Brizzolara, Antonella, Lanza, Francesco, Mosci, Carlo, Salvi, Sandra, Gualco, Marina, Truini, Mauro, Angelini, Giovanna, Boccardo, Simona, Cilli, Michele, Airoldi, Irma, Queirolo, Paola, Jager, Martine J, Daga, Antonio, Pfeffer, Ulrich, Ferrini, Silvano

“…Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of the patients, with a high lethality rate. Identification of patients at…”
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Therapeutic Potential of Proteasome Inhibition in Duchenne and Becker Muscular Dystrophies by Gazzerro, Elisabetta, Assereto, Stefania, Bonetto, Andrea, Sotgia, Federica, Scarfì, Sonia, Pistorio, Angela, Bonuccelli, Gloria, Cilli, Michele, Bruno, Claudio, Zara, Federico, Lisanti, Michael P, Minetti, Carlo

“…Duchenne muscular dystrophy (DMD) and its milder allelic variant, Becker muscular dystrophy (BMD), result from mutations of the dystrophin gene and lead to…”
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