Search Results - "CICALESE, Angelo"

p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling by Memmi, Elisa Maria, Sanarico, Anna Giulia, Giacobbe, Arianna, Peschiaroli, Angelo, Frezza, Valentina, Cicalese, Angelo, Pisati, Federica, Tosoni, Daniela, Zhou, Huiqing, Tonon, Giovanni, Antonov, Alexey, Melino, Gerry, Pelicci, Pier Giuseppe, Bernassola, Francesca

“…Significance p63, the sister homolog of p53, is a master regulator of epithelial stem cell (SC) biology. p63 is indeed intimately implicated in the maintenance…”
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DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions by Insinga, Alessandra, Cicalese, Angelo, Faretta, Mario, Gallo, Barbara, Albano, Luisa, Ronzoni, Simona, Furia, Laura, Viale, Andrea, Pelicci, Pier Giuseppe

“…DNA damage leads to a halt in proliferation owing to apoptosis or senescence, which prevents transmission of DNA alterations. This cellular response depends on…”
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In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype by Bossi, Daniela, Cicalese, Angelo, Dellino, Gaetano I, Luzi, Lucilla, Riva, Laura, D'Alesio, Carolina, Diaferia, Giuseppe R, Carugo, Alessandro, Cavallaro, Elena, Piccioni, Rossana, Barberis, Massimo, Mazzarol, Giovanni, Testori, Alessandro, Punzi, Simona, Pallavicini, Isabella, Tosti, Giulio, Giacó, Luciano, Melloni, Giorgio, Heffernan, Timothy P, Natoli, Gioacchino, Draetta, Giulio F, Minucci, Saverio, Pelicci, PierGiuseppe, Lanfrancone, Luisa

“…The identification of genes maintaining cancer growth is critical to our understanding of tumorigenesis. We report the first in vivo genetic screen of…”
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A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis by TRINEI, Mirella, GIORGIO, Marco, PETRONILLI, Valeria, MINUCCI, Saverio, BERNARDI, Paolo, LANFRANCONE, Luisa, PELICCI, Pier Giuseppe, CICALESE, Angelo, BAROZZI, Sara, VENTURA, Andrea, MIGLIACCIO, Enrica, MILIA, Elisabetta, PADURA, Ines Martin, RAKER, Veronica A, MACCARANA, Marco

“…Correlative evidence links stress, accumulation of oxidative cellular damage and ageing in lower organisms and in mammals. We investigated their mechanistic…”
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DNA damage response activation in mouse embryonic fibroblasts undergoing replicative senescence and following spontaneous immortalization by Di Micco, Raffaella, Cicalese, Angelo, Fumagalli, Marzia, Dobreva, Miryana, Verrecchia, Alessandro, Pelicci, Pier Giuseppe, di Fagagna, Fabrizio d'Adda

“…Primary mouse embryonic fibroblasts (MEFs) are a popular tool for molecular and cell biology studies. However, when MEFs are grown in vitro under standard…”
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The emerging role of p53 in stem cells by Bonizzi, Giuseppina, Cicalese, Angelo, Insinga, Alessandra, Pelicci, Pier Giuseppe

“…Among the hundreds of oncogenes and tumor suppressors that have been identified in the past 50 years, p53 is probably the best characterized; nevertheless, new…”
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DNA damage response in adult stem cells by Insinga, Alessandra, Cicalese, Angelo, Pelicci, Pier Giuseppe

“…This review discusses the processes of DNA-damage-response and DNA-damage repair in stem and progenitor cells of several tissues. The long life-span of stem…”
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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication by d'Adda di Fagagna, Fabrizio, Di Micco, Raffaella, Fumagalli, Marzia, Cicalese, Angelo, Piccinin, Sara, Gasparini, Patrizia, Luise, Chiara, Schurra, Catherine, Garre', Massimiliano, Giovanni Nuciforo, Paolo, Bensimon, Aaron, Maestro, Roberta, Giuseppe Pelicci, Pier

“…Early tumorigenesis is associated with the engagement of the DNA-damage checkpoint response (DDR). Cell proliferation and transformation induced by oncogene…”
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In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer by Carugo, Alessandro, Genovese, Giannicola, Seth, Sahil, Nezi, Luigi, Rose, Johnathon Lynn, Bossi, Daniela, Cicalese, Angelo, Shah, Parantu Krushnakant, Viale, Andrea, Pettazzoni, Piergiorgio Francesco, Akdemir, Kadir Caner, Bristow, Christopher Aaron, Robinson, Frederick Scott, Tepper, James, Sanchez, Nora, Gupta, Sonal, Estecio, Marcos Roberto, Giuliani, Virginia, Dellino, Gaetano Ivan, Riva, Laura, Yao, Wantong, Di Francesco, Maria Emilia, Green, Tessa, D’Alesio, Carolina, Corti, Denise, Kang, Ya’an, Jones, Philip, Wang, Huamin, Fleming, Jason Bates, Maitra, Anirban, Pelicci, Pier Giuseppe, Chin, Lynda, DePinho, Ronald Anthony, Lanfrancone, Luisa, Heffernan, Timothy Paul, Draetta, Giulio Francesco

“…Current treatment regimens for pancreatic ductal adenocarcinoma (PDAC) yield poor 5-year survival, emphasizing the critical need to identify druggable targets…”
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RNAi screens identify CHD4 as an essential gene in breast cancer growth by D'Alesio, Carolina, Punzi, Simona, Cicalese, Angelo, Fornasari, Lorenzo, Furia, Laura, Riva, Laura, Carugo, Alessandro, Curigliano, Giuseppe, Criscitiello, Carmen, Pruneri, Giancarlo, Pelicci, Pier Giuseppe, Faretta, Mario, Bossi, Daniela, Lanfrancone, Luisa

“…Epigenetic regulation plays an essential role in tumor development and epigenetic modifiers are considered optimal potential druggable candidates. In order to…”
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The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells by Cicalese, Angelo, Bonizzi, Giuseppina, Pasi, Cristina E., Faretta, Mario, Ronzoni, Simona, Giulini, Barbara, Brisken, Cathrin, Minucci, Saverio, Di Fiore, Pier Paolo, Pelicci, Pier Giuseppe

“…Stem-like cells may be integral to the development and maintenance of human cancers. Direct proof is still lacking, mainly because of our poor understanding of…”
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Abstract B43: PILOT: a patient-oriented in vivo functional platform to identify new lethalities and optimize cancer treatment by Carugo, Alessandro, Genovese, Giannicola, Seth, Sahil, Nezi, Luigi, Cicalese, Angelo, Bossi, Daniela, Rose, Johnathon L., Viale, Andrea, Lanfrancone, Luisa, Heffernan, Timothy P., Draetta, Giulio F.

“…Abstract Large-scale genomics efforts have provided the opportunity to access a comprehensive catalog of genetic alterations in multiple cancers. However, it…”
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Abstract A28: Challenging new epigenetic vulnerabilities in human metastatic melanoma PDXs by Bossi, Daniela, Cicalese, Angelo, Dellino, Ivan Gaetano, Luzi, Lucilla, Punzi, Simona, D'Alesio, Carolina, Cavallaro, Elena, Minucci, Saverio, Pelicci, PierGiuseppe, Lanfrancone, Luisa

“…Abstract Metastatic melanoma is one of the most aggressive cancers, refractory to most of the current therapies in its late stage. Melanoma is characterized by…”
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A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis by Trinei, M, Giorgio, M, Cicalese, A, Barozzi, S, Ventura, A, Migliaccio, E, Milia, E, Padura, I M, Raker, V A, Maccarana, M, Petronilli, V, Minucci, S, Bernardi, P, Lanfrancone, L, Pelicci, P G

“…Correlative evidence links stress, accumulation of oxidative cellular damage and ageing in lower organisms and in mammals. We investigated their mechanistic…”
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Abstract 1701: Identification of epigenetic modifiers able to suppress growth of pancreatic ductal adenocarcinoma: A patient-oriented in vivo functional platform by Carugo, Alessandro, Genovese, Giannicola, Seth, Sahil, Nezi, Luigi, Rose, Johnathon L., Viale, Andrea, Pettazzoni, Piergiorgio F., Cicalese, Angelo, Bossi, Daniela, Yao, Wantong, Fleming, Jason B., Lanfrancone, Luisa, Heffernan, Timothy P., Draetta, Giulio F.

“…Abstract We have seen great advances in our knowledge of the genetic regulation of various cancers in recent years, thanks in large part to large-scale genome…”
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Precision Photometer Heads as Primary Transducers in Devices Used to Measure Luminous Quantities by Ivanov, V S, Kotyuk, A F, Sapritskii, V I, Stolyarevskaya, R I

“…A precision photometer head that serves as a primary transducer in the block diagram of a modern physical photometer is described. Results are presented from…”
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