Search Results - "CIANA, P"

Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment by Garofalo, M., Saari, H., Somersalo, P., Crescenti, D., Kuryk, L., Aksela, L., Capasso, C., Madetoja, M., Koskinen, K., Oksanen, T., Mäkitie, A., Jalasvuori, M., Cerullo, V., Ciana, P., Yliperttula, M.

“…Standard of care for cancer is commonly a combination of surgery with radiotherapy or chemoradiotherapy. However, in some advanced cancer patients this…”
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Extracellular vesicles enhance the targeted delivery of immunogenic oncolytic adenovirus and paclitaxel in immunocompetent mice by Garofalo, M., Villa, A., Rizzi, N., Kuryk, L., Rinner, B., Cerullo, V., Yliperttula, M., Mazzaferro, V., Ciana, P.

“…Extracellular vesicles (EVs), are naturally occurring cargo delivery tools with the potential to be used as drug vehicles of single agents or combination…”
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The environmental chemical tributyltin chloride (TBT) shows both estrogenic and adipogenic activities in mice which might depend on the exposure dose by Penza, M., Jeremic, M., Marrazzo, E., Maggi, A., Ciana, P., Rando, G., Grigolato, P.G., Di Lorenzo, D.

“…Exposure during early development to chemicals with hormonal action may be associated with weight gain during adulthood because of altered body homeostasis. It…”
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Endocrine influence on neuroinflammation: the use of reporter systems by Rizzi, N., Villa, A., Benedusi, V., Brunialti, E., Cesari, N., Ciana, P., Maggi, A.

“…Most of the ageing‐associated pathologies are coupled with a strong inflammatory component that accelerates the progress of the physiopathological functional…”
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Estrogen Prevents the Lipopolysaccharide-Induced Inflammatory Response in Microglia by Vegeto, Elisabetta, Bonincontro, Cinzia, Pollio, Giuseppe, Sala, Angelo, Viappiani, Serena, Nardi, Francesca, Brusadelli, Alessia, Viviani, Barbara, Ciana, Paolo, Maggi, Adriana

“…After neuronal injury and in several neurodegenerative diseases, activated microglia secrete proinflammatory molecules that can contribute to the progressive…”
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Molecular imaging: A new way to study molecular processes in vivo by Ottobrini, L., Ciana, P., Biserni, A., Lucignani, G., Maggi, A.

“…Non-invasive imaging of reporter gene expression using different imaging modalities is increasing its role for the in vivo assessment of molecular processes…”
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In vitro estrogenic activity of Achillea millefolium L by Innocenti, G., Vegeto, E., Dall’Acqua, S., Ciana, P., Giorgetti, M., Agradi, E., Sozzi, A., Fico, G., Tomè, F.

“…Isolation and biological characterization of pure compounds was used to identify and characterize estrogenic activity and estrogen receptors (ER) preference in…”
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Estrogen Receptor-mediated Transcriptional Activity of Genistein in the Mouse Testis by Montani, C., Penza, M., Jeremic, M., Rando, G., Ciana, P., Maggi, A., La Sala, G., De Felici, M., Di Lorenzo, D.

“…Here we show that genistein, through an estrogen receptor‐mediated action, modulates gene expression in the mouse testis throughout development. Genistein…”
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Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory by Cooper, C'iana P., Shafer, Andrea T., Armstrong, Nicole M., An, Yang, Erus, Guray, Davatzikos, Christos, Ferrucci, Luigi, Rapp, Peter R., Resnick, Susan M.

“…•Cross-sectional and longitudinal cerebellar volume and verbal memory were examined.•Identified age-dependent cross-sectional associations with baseline…”
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Cerebellum Purkinje cell vulnerability in aged rats with memory impairment by Cooper, C'iana P., Cheng, Liam H., Bhatti, Jafar A., Rivera, Edward L., Huell, Derek, Banuelos, Cristina, Perez, Evelyn J., Long, Jeffrey M., Rapp, Peter R.

“…The cerebellum is involved in higher order cognitive function and is susceptible to age‐related atrophy. However, limited evidence has directly examined the…”
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Recognition Memory is Associated with Distinct Patterns of Regional Gray Matter Volumes in Young and Aged Monkeys by Cooper, C’iana P, Shafer, Andrea T, Armstrong, Nicole M, Rossi, Sharyn L, Young, Jennifer, Herold, Christa, Gu, Hong, Yang, Yihong, Stein, Elliot A, Resnick, Susan M, Rapp, Peter R

“…Abstract Cognitive aging varies tremendously across individuals and is often accompanied by regionally specific reductions in gray matter (GM) volume, even in…”
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Estrogen blocks inducible nitric oxide synthase accumulation in LPS-activated microglia cells by Vegeto, E, Pollio, G, Ciana, P, Maggi, A

“…Estrogens are thought to play a protective role against neurodegeneration through a variety of mechanisms including the activation of growth factors and…”
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Multimodality imaging: novel pharmacological applications of reporter systems by Stell, A, Belcredito, S, Ramachandran, B, Biserni, A, Rando, G, Ciana, P, Maggi, A

“…The development of novel drugs is a lengthy process requiring years of preclinical research and many steps indispensable to ensure that the molecule of…”
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Isomer-Specific Activity of Dichlorodyphenyl-trichloroethane with Estrogen Receptor in Adult and Suckling Estrogen Reporter Mice by Di Lorenzo, D, Villa, R, Biasiotto, G, Belloli, S, Ruggeri, G, Albertini, A, Apostoli, P, Raviscioni, M, Ciana, P, Maggi, A

“…We investigated the tissue-specific effects of dichlorodyphenyltrichloroethane (DDT) isomers in adult and suckling newborn mice, using a novel mouse line…”
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Activation of brain estrogen receptors in mice lactating from mothers exposed to DDT by Mussi, P., Ciana, P., Raviscioni, M., Villa, R., Regondi, S., Agradi, E., Maggi, A., Lorenzo, D. Di

“…The insecticide dichlorodiphenyltrichloroethane (DDT) interferes with physiological endocrine processes modulating estrogens receptor activity. Most of the…”
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The dynamics of estrogen receptor activity by Ciana, P., Scarlatti, F., Biserni, A., Ottobrini, L., Brena, A., Lana, A., Zagari, F., Lucignani, G., Maggi, A.

“…In the latest few years, the merging of imaging and animal engineering technologies has led to the generation of innovative tools that provide the opportunity…”
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Target-specific action of organochlorine compounds in reproductive and nonreproductive tissues of estrogen-reporter male mice by Villa, R, Bonetti, E., Penza, M.L., Iacobello, C., Bugari, G., Bailo, M., Parolini, O., Apostoli, P., Caimi, L., Ciana, P., Maggi, A., Di Lorenzo, D.

“…Organochlorines are lipophylic molecules that accumulate in the fat where they remain for years. During weight loss, they are mobilized and their concentration…”
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Oestrogen Prevention of Neural Cell Death Correlates with Decreased Expression of mRNA for the Pro-Apoptotic Protein Nip-2 by Meda, C., Vegeto, E., Pollio, G., Ciana, P., Patrone, C., Pellicciari, C., Maggi, A.

“…We have recently identified nip‐2 as a gene target for 17β‐oestradiol activity in the neuroblastoma SK‐ER3 cells expressing the oestrogen receptor (ER) α. Here…”
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Whole body action of xenoestrogens with different chemical structures in estrogen reporter male mice by Penza, M., Bonetti, E., Villa, R., Ganzerla, S., Bergonzi, R., Biasiotto, G., Caimi, L., Apostoli, P., Ciana, P., Maggi, A., Lorenzo, D. Di

“…The present work tested the estrogenic activity of three weak environmental estrogens p, p′DDT [1,1,1-trichloro-2,2-bis( p-chlorophenyl) ethane], p, p′DDE…”
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Heterogeneous Chromosomal Aberrations Generate 3′ Truncations of the NFKB2/lyt-10 Gene in Lymphoid Malignancies by Migliazza, Anna, Lombardi, Luigia, Rocchi, Mariano, Trecca, Dino, Chang, Chih-Chao, Antonacci, Rachele, Fracchiolla, Nicola Stefano, Ciana, Paolo, Maiolo, Anna Teresa, Neri, Antonino

“…The IMFKB2 (Iyt-10) gene codes for a protein that is a member of the NF-κB/rel family of transcription factors containing a DNA-binding rel domain and a…”
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