Search Results - "CIACCIO, P. J"

Validation of an in vitro screen for phospholipidosis using a high-content biology platform by Morelli, J K, Buehrle, M, Pognan, F, Barone, L R, Fieles, W, Ciaccio, P J

“…Several cationic amphiphilic drugs cause local or systemic phospholipidosis (PLD) after chronic exposure in preclinical species. PLD is characterized by the…”
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Isozyme-specific glutathione S-transferase inhibitors potentiate drug sensitivity in cultured human tumor cell lines by MORGAN, A. S, CIACCIO, P. J, TEW, K. D, KAUVAR, L. M

“…Novel glutathione (GSH) analogs, previously shown to inhibit glutathione S-transferase (GST) activity at about 1 microM in vitro, were tested for their ability…”
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Investigation of the Positive Response of Ethyl Acrylate in the Mouse Lymphoma Genotoxicity Assay by Ciaccio, P. J., Gicquel, E., O'Neill, P. J., Scribner, H. E., Vandenberghe, Y. L.

“…To develop a better understanding of the relationship between ethyl acrylate (EA)-induced cytotoxicity and mutation frequency in the mouse lymphoma assay (MLA)…”
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Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid by Ciaccio, P J, Tew, K D, LaCreta, F P

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Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics by Ciaccio, P J, Jaiswal, A K, Tew, K D

“…A human oxidoreductase (H-37) that is overexpressed in ethacrynic acid-resistant HT29 colon cells (Ciaccio, P. J., Stuart, J.E., and Tew, K.D. (1993) Mol…”
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Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells by Ciaccio, P J, Stuart, J E, Tew, K D

“…We report the initial identification of a 37.5-kDa putative aldoketo reductase in human colon carcinoma cells. An aminoterminal trypsin fragment was sequenced…”
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Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors by Ciaccio, P J, Shen, H, Jaiswal, A K, Lyttle, M H, Tew, K D

“…We investigated the effects of glutathione-S-transferase (GST) inhibitor treatment on human colon HT29 cell mRNA levels of dihydrodiol dehydrogenase (DDH),…”
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Adaptive response to glutathione S-transferase inhibitors by Ciaccio, P J, Tew, K D

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cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase by Ciaccio, P J, Tew, K D

“…A 1.24 kbp cDNA encoding a human colon HT29 cell dihydrodiol dehydrogenase of 323 amino acid residues (M(r) 36,735) has been isolated and sequenced. The…”
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Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily by Ciaccio, P J, Halpert, J R

“…A cytochrome P450 called PBD-1 isolated from liver microsomes of an adult male Beagle dog treated with phenobarbital (PB) is structurally and functionally…”
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Selective inactivation by chloramphenicol of the major phenobarbital-inducible isozyme of dog liver cytochrome P-450 by Ciaccio, P J, Duignan, D B, Halpert, J R

“…Chloramphenicol (CAP) is a potent and effective mechanism-based inactivator of the major phenobarbital (PB)-inducible isozyme of dog liver cytochrome P-450…”
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Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation by Ranganathan, Sulabha, Ciaccio, Paul J., Walsh, Eileen S., Tew, Kenneth D.

“…Glyoxalase-I is a glutathione-binding protein involved in the detoxification of methylglyoxal, a by-product of glycolysis. Aberrations in the expression of…”
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The metabolism of xenobiotics and endogenous compounds by the constitutive dog liver cytochrome P450 PBD-2 by Duignan, D B, Sipes, I G, Ciaccio, P J, Halpert, J R

“…We have investigated the metabolism of polychlorinated biphenyls and endogenous steroids by the major phenobarbital (PB)-inducible hepatic cytochromes P450 in…”
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Cellular and in Vitro Transport of Glutathione Conjugates by MRP by Shen, Hongxie, Paul, Saptarshi, Breuninger, Lisa M, Ciaccio, Paul J, Laing, Naomi M, Helt, Marija, Tew, Kenneth D, Kruh, Gary D

“…MRP is a recently identified ATP-binding cassette transporter. We previously established that MRP confers resistance to a spectrum of natural product cytotoxic…”
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Effects of Chronic Ethacrynic Acid Exposure on Glutathione Conjugation and MRP Expression in Human Colon Tumor Cells by Ciaccio, Paul J., Shen, Hongxie, Kruh, Gary D., Tew, Kenneth D.

“…Chronic exposure to ethacrynic acid of a subcloned HT29 human colon cancer cell line produces a 3- to 4-fold increase in the level of resistance to this agent…”
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Promoter Analysis of a Human Dihydrodiol Dehydrogenase by Ciaccio, Paul J., Walsh, Eileen S., Tew, Kenneth D.

“…The 5′ flanking region of a human dihydrodiol dehydrogenase (DDH) gene was isolated and sequenced from bp +124 to −1161. It contains putative binding sites for…”
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The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione by Ciaccio, P J, Tew, K D, LaCreta, F P

“…Incubation of 100 microM chlorambucil (CMB) with 1 mM glutathione (GSH) in 0.1 M potassium phosphate buffer yielded a mixture of GSH conjugates and hydrolytic…”
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cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl by Graves, P E, Elhag, G A, Ciaccio, P J, Bourque, D P, Halpert, J R

“…The nucleotide sequence of a cDNA that codes for the major phenobarbital (PB)-inducible male beagle dog hepatic cytochrome P450 has been determined. Using a…”
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Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation by Milano, Joseph, McKay, Jenny, Dagenais, Claude, Foster-Brown, Linda, Pognan, Francois, Gadient, Reto, Jacobs, Robert T., Zacco, Anna, Greenberg, Barry, Ciaccio, Paul J.

“…It is anticipated that γ-secretase inhibitors (γ-Sec-I) that modulate Notch processing will alter differentiation in tissues whose architecture is governed by…”
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cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily by Ciaccio, P J, Graves, P E, Bourque, D P, Glinsmann-Gibson, B, Halpert, J R

“…A 1.96 kbp cDNA encoding a male Beagle dog liver cytochrome P-450 of 503 amino acid residues (Mr 57,636) has been isolated and sequenced. The deduced amino…”
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