Search Results - "CHURN, S. B"

Ischemia‐Induced Inhibition of Calcium Uptake into Rat Brain Microsomes Mediated by Mg2+/Ca2+ ATPase by Parsons, J. T., Churn, S. B., DeLorenzo, R. J.

“…: It is well established that ischemia is associated with prolonged increases in neuronal intracellular free calcium levels. Recent data suggest that…”
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Status epilepticus results in an N-methyl-D-aspartate receptor-dependent inhibition of Ca2+/calmodulin-dependent kinase II activity in the rat by KOCHAN, L. D, CHURN, S. B, OMOJOKUN, O, RICE, A, DELORENZO, R. J

“…Status epilepticus is a major medical emergency that results in significant alteration of neuronal function. Status epilepticus involves seizure activity…”
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Temperature modulation of ischemic neuronal death and inhibition of calcium/calmodulin-dependent protein kinase II in gerbils by CHURN, S. B, TAFT, W. C, BILLINGSLEY, M. S, BLAIR, R. E, DELORENZO, R. J

“…We used brief bilateral carotid artery occlusion in gerbils to examine the effects of temperature on ischemia-induced inhibition of…”
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Inability to restore resting intracellular calcium levels as an early indicator of delayed neuronal cell death by Limbrick, David D., Churn, Severn B., Sombati, Sompong, DeLorenzo, Robert J.

“…The hippocampus is especially vulnerable to excitotoxicity and delayed neuronal cell death. Chronic elevations in free intracellular calcium concentration ([Ca…”
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Long-lasting decrease in neuronal Ca2+/calmodulin-dependent protein kinase II activity in a hippocampal neuronal culture model of spontaneous recurrent seizures by BLAIR, R. E, CHURN, S. B, SOMBATI, S, LOU, J. K, DELORENZO, R. J

“…Ca2+/calmodulin-dependent protein kinase II (CaM Kinase II) activity was evaluated in a well-characterized in vitro model of epileptiform activity…”
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Expression of the α and β subunits of Ca2+/calmodulin kinase II in the cerebellum of jaundiced Gunn rats during development : a quantitative light microscopic analysis by CONLEE, J. W, SHAPIRO, S. M, CHURN, S. B

“…The homozygous (jj) jaundiced Gunn rat model for hyperbilirubinemia displays pronounced cerebellar hypoplasia. To examine the cellular mechanisms involved in…”
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Modulation of GABAergic receptor binding by activation of calcium and calmodulin-dependent kinase II membrane phosphorylation by Churn, Severn B., DeLorenzo, Robert J.

“…γ-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system (CNS). Because of the important role that GABA plays in the…”
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Global forebrain ischemia results in decreased immunoreactivity of calcium/calmodulin-dependent protein kinase II by Churn, S B, Yaghmai, A, Povlishock, J, Rafiq, A, DeLorenzo, R J

“…Previous studies utilizing crude brain homogenates have shown that forebrain ischemia results in inhibition of calcium/calmodulin-dependent protein kinase II…”
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Bilirubin induces a calcium-dependent inhibition of multifunctional Ca2+/calmodulin-dependent kinase II activity in vitro by CHURN, S. B, DELORENZO, R. J, SHAPIRO, S. M

“…Excessive bilirubin levels in newborn infants result in long-term neurologic deficits that remain after bilirubin levels return to normal. Much of the observed…”
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Excitotoxicity affects membrane potential and calmodulin kinase II activity in cultured rat cortical neurons by CHURN, S. B, SOMBATI, S, TAFT, W. C, DELORENZO, R. J, ZIVIN, J

“…Glutamate-induced excitotoxicity has been implicated as a causative factor for selective neuronal loss in ischemia and hypoxia. Toxic exposure of neurons to…”
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Effects of ischemia on multifunctional calcium/calmodulin-dependent protein kinase type II in the gerbil by Churn, S B, Taft, W C, DeLorenzo, R J

“…Cerebral ischemia produces a disruption of calcium homeostasis in neurons. This may explain the extreme sensitivity of these cells to ischemic insult…”
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Loss of type II calcium/calmodulin-dependent kinase activity correlates with stages of development of electrographic seizures in status epilepticus in rat by Perlin, J B, Churn, S B, Lothman, E W, DeLorenzo, R J

“…Understanding the molecular basis of altered neuronal excitability in epilepsy is a major challenge in neuroscience research. The present study suggests an…”
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A persistent change in subcellular distribution of calcineurin following fluid percussion injury in the rat by Kurz, Jonathan E., Hamm, Robert J., Singleton, Richard H., Povlishock, John T., Churn, Severn B.

“…Calcineurin, a neuronally enriched, calcium-stimulated phosphatase, is an important modulator of many neuronal processes, including several that are…”
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Chronic inhibition of Ca(2+)/calmodulin kinase II activity in the pilocarpine model of epilepsy by Churn, S B, Kochan, L D, DeLorenzo, R J

“…The development of symptomatic epilepsy is a model of long-term plasticity changes in the central nervous system. The rat pilocarpine model of epilepsy was…”
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A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus by Kurz, Jonathan E., Sheets, Dan, Parsons, J. Travis, Rana, Aniruddha, Delorenzo, Robert J., Churn, Severn B.

“…This study focused on the effects of status epilepticus on the activity of calcineurin, a neuronally enriched, calcium‐dependent phosphatase. Calcineurin is an…”
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Ischemic brain injury selectively alters ATP binding of calcium and calmodulin-dependent protein kinase II by Churn, S B, Sankaran, B, Haley, B E, DeLorenzo, R J

“…Calmodulin and ATP affinity and total binding capacity were characterized for CaM kinase II isolated from control and ischemic animals. Ischemic CaM kinase II…”
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Exposure of hippocampal slices to magnesium-free medium produces epileptiform activity and simultaneously decreases calcium and calmodulin-dependent protein kinase II activity by Churn, S B, Anderson, W W, DeLorenzo, R J

“…The effect of magnesium-free medium on electrical and CaM kinase II activity in the rat hippocampal slice was examined. Experimental slices were incubated in 2…”
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Chronic inhibition of Ca2+/calmodulin kinase II activity in the pilocarpine model of epilepsy by CHURN, S. B, KOCHAN, L. D, DELORENZO, R. J

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Inhibition of Calcium/Calmodulin Kinase II Alpha Subunit Expression Results in Epileptiform Activity in Cultured Hippocampal Neurons by Churn, Severn B., Sombati, Sompong, Jakoi, Emma R., Sievert, Lawrence, DeLorenzo, Robert J.

“…Several models that develop epileptiform discharges and epilepsy have been associated with a decrease in the activity of calmodulin-dependent kinase II…”
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Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons by Churn, SB, Limbrick, D, Sombati, S, DeLorenzo, RJ

“…Neurotoxic effects of excitatory amino acids have been implicated in various neurological disorders, and have been utilized for excitotoxic models of delayed…”
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