Search Results - "CHUNHAI HAO"

SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression by Bellail, Anita C., Olson, Jeffrey J., Hao, Chunhai

“…Ubiquitination governs oscillation of cyclin-dependent kinase (CDK) activity through a periodic degradation of cyclins for orderly cell cycle progression;…”
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Fibrinogen in the glioblastoma microenvironment contributes to the invasiveness of brain tumor‐initiating cells by Dzikowski, Lauren, Mirzaei, Reza, Sarkar, Susobhan, Kumar, Mehul, Bose, Pinaki, Bellail, Anita, Hao, Chunhai, Yong, V. Wee

“…Glioblastomas (GBMs) are highly aggressive, recurrent, and lethal brain tumors that are maintained via brain tumor‐initiating cells (BTICs). The aggressiveness…”
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Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation by Yan, Dan, Ng, Wooi Loon, Zhang, Xiangming, Wang, Ping, Zhang, Zhaobin, Mo, Yin-Yuan, Mao, Hui, Hao, Chunhai, Olson, Jeffrey J, Curran, Walter J, Wang, Ya

“…Radiotherapy kills tumor-cells by inducing DNA double strand breaks (DSBs). However, the efficient repair of tumors frequently prevents successful treatment…”
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Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis by Shu, Hui-Kuo G, Yoon, Younghyoun, Hong, Samuel, Xu, Kaiming, Gao, Huiying, Hao, Chunhai, Torres-Gonzalez, Edilson, Nayra, Cardenes, Rojas, Mauricio, Shim, Hyunsuk

“…A devastating late injury caused by radiation is pulmonary fibrosis. This risk may limit the volume of irradiation and compromise potentially curative therapy…”
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A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma by Bellail, Anita C, Olson, Jeffrey J, Yang, Xiaolu, Chen, Zhijian J, Hao, Chunhai

“…The TNF-related apoptosis-inducing ligand (TRAIL) apoptotic pathway has emerged as a therapeutic target for the treatment of cancer. However, clinical trials…”
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CXCR4 Is a Major Chemokine Receptor on Glioma Cells and Mediates Their Survival by Zhou, Yan, Larsen, Peter H., Hao, Chunhai, Yong, V. Wee

“…Chemokines were described originally in the context of providing migrational cues for leukocytes. They are now known to have broader activities, including…”
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Celecoxib Promotes c-FLIP Degradation through Akt-Independent Inhibition of GSK3 by SHUZHEN CHEN, WEI CAO, PING YUE, CHUNHAI HAO, KHURI, Fadlo R, SUN, Shi-Yong

“…Celecoxib is a COX-2 inhibitor that reduces the risk of colon cancer. However, the basis for its cancer chemopreventive activity is not fully understood. In…”
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Lipid rafts and nonrafts mediate tumor necrosis factor-related apoptosis-inducing ligand-induced apoptotic and nonapoptotic signals in non-small cell lung carcinoma cells by SONG, Jin H, TSE, Margaret C. L, BELLAIL, Anita, PHUPHANICH, Surasak, KHURI, Fadlo, KNETEMAN, Norman M, CHUNHAI HAO

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is capable of inducing apoptosis in non-small cell lung carcinoma (NSCLC). However, many of the…”
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TRAIL agonists on clinical trials for cancer therapy: the promises and the challenges by Bellail, Anita C, Qi, Ling, Mulligan, Patrick, Chhabra, Vaninder, Hao, Chunhai

“…Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is normally expressed in the human immune system and plays a critical role in antitumor…”
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RNAi-Mediated Targeting of Noncoding and Coding Sequences in DNA Repair Gene Messages Efficiently Radiosensitizes Human Tumor Cells by ZHIMING ZHENG, WOOI LOON NG, XIANGMING ZHANG, OLSON, Jeffrey J, CHUNHAI HAO, CURRAN, Walter J, YA WANG

“…Human tumor cell death during radiotherapy is caused mainly by ionizing radiation (IR)-induced DNA double-strand breaks (DSB), which are repaired by either…”
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Cisplatin Restores TRAIL Apoptotic Pathway in Glioblastoma-Derived Stem Cells through Up-regulation of DR5 and Down-regulation of c-FLIP by Ding, Lijuan, Yuan, Changji, Wei, Feng, Wang, Guangyi, Zhang, Jing, Bellail, Anita C., Zhang, Zhaobin, Olson, Jeffrey J., Hao, Chunhai

“…Glioblastoma-derived stem cells (GSCs) are responsible for the cancer resistance to therapies. We show here that GSC-enriched neurospheres are resistant to the…”
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Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma by Wang, Quan, Wei, Feng, Li, Chunsheng, Lv, Guoyue, Wang, Guangyi, Liu, Tongjun, Bellail, Anita C, Hao, Chunhai

“…Mammalian target of rapamycin complex 1 and 2 (mTORC1/2) are overactive in colorectal carcinomas; however, the first generation of mTOR inhibitors such as…”
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Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Death-inducing Signaling Complex and Its Modulation by c-FLIP and PED/PEA-15 in Glioma Cells by Xiao, Chang, Yang, Bao Feng, Asadi, Neda, Beguinot, Francesco, Hao, Chunhai

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can trigger apoptosis in some tumor cells but not other tumor cells. To explore the signal…”
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Apolipoprotein E ϵ4 and catechol-O-methyltransferase alleles in autopsy-proven Parkinson's disease: Relationship to dementia and hallucinations by Camicioli, Richard, Rajput, Ali, Rajput, Michelle, Reece, Christian, Payami, Haydeh, Hao, Chunhai, Rajput, Alex

“…We determined whether apolipoprotein E ϵ4 (ApoE4) or catechol‐O‐methyltransferase (COMT) genotypes were associated with dementia, hallucinations, Alzheimer's…”
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Th1 and Th2 Immune Response in Chronic Hepatitis B Patients during a Long-Term Treatment with Adefovir Dipivoxil by Niu, Junqi, Zhao, Pingwei, Jiang, Yan-Fang, Hao, Chunhai, Xu, Huining, Li, Wan-Yu, Ma, Zhenhua, Xin, Guijie, Yan, Hongqing

“…Adefovir dipivoxil treatment has significantly improved the outcome of chronic hepatitis B virus (HBV) infection. However, it remains largely unknown how…”
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Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome by Chan, Chi-Bun, Abe, Michiyo, Hashimoto, Noriyoshi, Hao, Chunhai, Williams, Ifor R, Liu, Xia, Nakao, Shinji, Yamamoto, Akitsugu, Li, Shi-Yong, Hara-Nishimura, Ikuko, Asano, Masahide, Ye, Keqiang

“…Asparaginyl endopeptidase (AEP or legumain) is a lysosomal cysteine protease that cleaves protein substrates on the C-terminal side of asparagine. AEP plays a…”
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Inhibition of RIP and c-FLIP enhances TRAIL-induced apoptosis in pancreatic cancer cells by Wang, Peng, Zhang, Jing, Bellail, Anita, Jiang, Wen, Hugh, Judith, Kneteman, Norman M., Hao, Chunhai

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has recently emerged as a cancer therapeutic agent because it is capable of preferentially…”
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TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice by HAO, Chunhai, SONG, Jin H, HSI, Belinda, LEVIS, Jamie, SONG, Doyoun K, PETRUK, Kenneth C, TYRRELL, David L. J, KNETEMAN, Norman M

“…Tumor necrosis factor (TNF) family ligand TNF-alpha and Fas ligand (FasL) can trigger apoptosis in solid tumors, but their clinical usage has been limited by…”
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Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells by CHUNHAI HAO, BEGUINOT, Francesco, CONDORELLI, Gerolama, TRENCIA, Alessandra, VAN MEIR, Erwin G, YONG, V. Wee, PARNEY, Ian F, ROA, Wilson H, PETRUK, Kenneth C

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially triggers apoptosis in tumor cells versus normal cells, thus providing a…”
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Simultaneous targeting of EGFR and mTOR inhibits the growth of colorectal carcinoma cells by BO LI, SHUOHUI GAO, FENG WEI, BELLAIL, Anita C, CHUNHAI HAO, TONGJUN LIU

“…Epidermal growth factor receptor (EGFR) is highly expressed in colorectal carcinomas and, as a result, it leads to the activation of downstream mammalian…”
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