Search Results - "CHUNG, W. K"

Investigation of the Mechanism of C(sp3)−H Bond Cleavage in Pd(0)-Catalyzed Intramolecular Alkane Arylation Adjacent to Amides and Sulfonamides by Rousseaux, Sophie, Gorelsky, Serge I, Chung, Benjamin K. W, Fagnou, Keith

“…The reactivity of C(sp3)−H bonds adjacent to a nitrogen atom can be tuned to allow intramolecular alkane arylation under Pd(0) catalysis. Diminishing the Lewis…”
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Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis by Josson, S, Gururajan, M, Sung, S Y, Hu, P, Shao, C, Zhau, H E, Liu, C, Lichterman, J, Duan, P, Li, Q, Rogatko, A, Posadas, E M, Haga, C L, Chung, L W K

“…Tumor–stromal interaction is a dynamic process that promotes tumor growth and metastasis via cell–cell interaction and extracellular vesicles. Recent studies…”
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Snail promotes epithelial mesenchymal transition in breast cancer cells in part via activation of nuclear ERK2 by Smith, Bethany N, Burton, Liza J, Henderson, Veronica, Randle, Diandra D, Morton, Derrick J, Smith, Basil A, Taliaferro-Smith, Latonia, Nagappan, Peri, Yates, Clayton, Zayzafoon, Majd, Chung, Leland W K, Odero-Marah, Valerie A

“…Snail transcription factor is up-regulated in several cancers and associated with increased tumor migration and invasion via induction of…”
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KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway by Yin, Lijuan, Li, Qinlong, Mrdenovic, Stefan, Chu, Gina Chia-Yi, Wu, Boyang Jason, Bu, Hong, Duan, Peng, Kim, Jayoung, You, Sungyong, Lewis, Michael S, Liang, Gangning, Wang, Ruoxiang, Zhau, Haiyen E, Chung, Leland W K

“…Keratins (KRTs) are intermediate filament proteins that interact with multiple regulatory proteins to initiate signaling cascades. Keratin 13 (KRT13) plays an…”
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Kinship of conditionally immortalized cells derived from fetal bone to human bone-derived mesenchymal stroma cells by Marozin, S., Simon-Nobbe, B., Irausek, S., Chung, L. W. K., Lepperdinger, G.

“…The human fetal osteoblast cell line (hFOB 1.19) has been proposed as an accessible experimental model for study of osteoblast biology relating to drug…”
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KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer by Cao, Zhi, Shi, Xiaolei, Tian, Feng, Fang, Yu, Wu, Jason Boyang, Mrdenovic, Stefan, Nian, Xinwen, Ji, Jin, Xu, Huan, Kong, Chen, Xu, Yalong, Chen, Xi, Huang, Yuhua, Wei, Xuedong, Yu, Yongwei, Yang, Bo, Chung, Leland W. K., Wang, Fubo

“…Lysine (K)-specific demethylase 6B (KDM6B), a stress-inducible H3K27me3 demethylase, plays oncogenic or antitumoral roles in malignant tumors depending on the…”
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LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling by Lue, Hui-Wen, Yang, Xiaojian, Wang, Ruoxiang, Qian, Weiping, Xu, Roy Z H, Lyles, Robert, Osunkoya, Adeboye O, Zhou, Binhua P, Vessella, Robert L, Zayzafoon, Majd, Liu, Zhi-Ren, Zhau, Haiyen E, Chung, Leland W K

“…LIV-1, a zinc transporter, is an effector molecule downstream from soluble growth factors. This protein has been shown to promote epithelial-to-mesenchymal…”
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RANK-mediated signaling network and cancer metastasis by Chu, Gina Chia-Yi, Chung, Leland W. K.

“…Cancer metastasis is highly inefficient and complex. Common features of metastatic cancer cells have been observed using cancer cell lines and genetically…”
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β2-Microglobulin Induces Epithelial to Mesenchymal Transition and Confers Cancer Lethality and Bone Metastasis in Human Cancer Cells by JOSSON, Sajni, NOMURA, Takeo, LIN, Jen-Tai, HUANG, Wen-Chin, DAQING WU, ZHAU, Haiyen E, ZAYZAFOON, Majd, WEIZMANN, M. Neale, GURURAJAN, Murali, CHUNG, Leland W. K

“…Bone metastasis is one of the predominant causes of cancer lethality. This study demonstrates for the first time how β2-microglobulin (β2-M) supports lethal…”
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A cisplatin conjugate with tumor cell specificity exhibits antitumor effects in renal cancer models by Mrdenovic, Stefan, Wang, Yanping, Yin, Lijuan, Chu, Gina Chia-Yi, Ou, Yan, Lewis, Michael S, Heffer, Marija, Posadas, Edwin M, Zhau, Haiyen E, Chung, Leland W K, Edderkaoui, Mouad, Pandol, Stephen J, Wang, Ruoxiang, Zhang, Yi

“…Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and is notorious for its resistance to both chemotherapy and small-molecule…”
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Ethanol ablation of predominantly cystic thyroid nodules: Evaluation of recurrence rate and factors related to recurrence by Suh, C.H, Baek, J.H, Ha, E.J, Choi, Y.J, Lee, J.H, Kim, J.K, Chung, K.-W, Kim, T.Y, Kim, W.B, Shong, Y.K

“…Aim To evaluate recurrence rate and associated risk factors for recurrence after ethanol ablation (EA) in patients with predominantly cystic thyroid nodules…”
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miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer by JOSSON, Sajni, GURURAJAN, Murali, LICHTERMAN, Jake, NANDANA, Srinivas, QUANLIN LI, ROGATKO, Andre, BEREL, Dror, POSADAS, Edwin M, FAZLI, Ladan, SAREEN, Dhruv, CHUNG, Leland W. K, PEIZHEN HU, CHEN SHAO, CHU, Ginachia-Yi, ZHAU, Haiyen E, CHUNYAN LIU, KAIQIN LAO, LU, Chia-Lun, LU, Yi-Tsung

“…miR-409-3p/-5p is a miRNA expressed by embryonic stem cells, and its role in cancer biology and metastasis is unknown. Our pilot studies demonstrated elevated…”
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Photocatalytic oxidation of polycyclic aromatic hydrocarbons: Intermediates identification and toxicity testing by Woo, O.T., Chung, W.K., Wong, K.H., Chow, Alex T., Wong, P.K.

“…Polycyclic aromatic hydrocarbons (PAHs) are hydrophobic pollutants and their low water solubility limits their degradation in aqueous solution. The presence of…”
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Spontaneous cancer-stromal cell fusion as a mechanism of prostate cancer androgen-independent progression by Wang, Ruoxiang, Sun, Xiaojuan, Wang, Christopher Y, Hu, Peizhen, Chu, Chia-Yi, Liu, Shurong, Zhau, Haiyen E, Chung, Leland W K

“…We have previously shown that human prostate cancer cells are capable of acquiring malignant attributes through interaction with stromal cells in the tumor…”
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Six-Minute Walk Test demonstrates motor fatigue in spinal muscular atrophy by MONTES, J, MCDERMOTT, M. P, CHUNG, W. K, DARRAS, B. T, DE VIVO, D. C, KAUFMANN, P, FINKEL, R. S, MARTENS, W. B, DUNAWAY, S, GLANZMAN, A. M, RILEY, S, QUIGLEY, J, MONTGOMERY, M. J, SPROULE, D, TAWIL, R

“…In spinal muscular atrophy (SMA), weakness, decreased endurance, and fatigue limit mobility. Scales have been developed to measure function across the wide…”
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Genetic association analysis of 30 genes related to obesity in a European American population by Li, P, Tiwari, H K, Lin, W-Y, Allison, D B, Chung, W K, Leibel, R L, Yi, N, Liu, N

“…OBJECTIVE: Obesity, which is frequently associated with diabetes, hypertension and cardiovascular diseases, is primarily the result of a net excess of caloric…”
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Multiplexed quantum dot labeling of activated c-Met signaling in castration-resistant human prostate cancer by Hu, Peizhen, Chu, Gina C-Y, Zhu, Guodong, Yang, Hua, Luthringer, Daniel, Prins, Gail, Habib, Fouad, Wang, Yuzhuo, Wang, Ruoxiang, Chung, Leland W K, Zhau, Haiyen E

“…The potential application of multiplexed quantum dot labeling (MQDL) for cancer detection and prognosis and monitoring therapeutic responses has attracted the…”
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Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2-WNT Signaling Axis by Nandana, Srinivas, Tripathi, Manisha, Duan, Peng, Chu, Chia-Yi, Mishra, Rajeev, Liu, Chunyan, Jin, Renjie, Yamashita, Hironobu, Zayzafoon, Majd, Bhowmick, Neil A, Zhau, Haiyen E, Matusik, Robert J, Chung, Leland W K

“…Identification of factors that mediate visceral and bone metastatic spread and subsequent bone remodeling events is highly relevant to successful therapeutic…”
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Reactive oxygen species–mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression by Hsieh, Chia-Ling, Liu, Che-Ming, Chen, Hsin-An, Yang, Shun-Tai, Shigemura, Katsumi, Kitagawa, Koichi, Yamamichi, Fukashi, Fujisawa, Masato, Liu, Yun-Ru, Lee, Wei-Hua, Chen, Kuan-Chou, Shen, Chia-Ning, Lin, Cheng-Chieh, Chung, Leland W. K., Sung, Shian-Ying

“…Studies on the aberrant control of extracellular matrices (ECMs) have mainly focused on the role of malignant cells but less on that of stromal fibroblasts…”
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Being small for gestational age is not an independent risk factor for mortality in neonates with congenital diaphragmatic hernia: a multicenter study by Zenilman, A., Fan, W., Hernan, R., Wynn, J., Abramov, A., Farkouh-Karoleski, C., Aspelund, G., Krishnan, U. S., Khlevner, J., Azarow, K., Crombleholme, T., Cusick, R., Chung, D., Danko, M. E., Potoka, D., Lim, F. Y., McCulley, D. J., Mychaliska, G. B., Schindel, D., Soffer, S., Wagner, A. J., Warner, B. W., Chung, W. K., Duron, V. P.

“…Background Congenital diaphragmatic hernia (CDH) accounts for 8% of all major congenital anomalies. Neonates who are small for gestational age (SGA) generally…”
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