Search Results - "CHUANRUI XU"

β-Catenin signaling in hepatocellular carcinoma by Xu, Chuanrui, Xu, Zhong, Zhang, Yi, Evert, Matthias, Calvisi, Diego F, Chen, Xin

“…Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular carcinoma (HCC). Comprehensive genomic analyses have…”
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Bmal1 integrates mitochondrial metabolism and macrophage activation by Alexander, Ryan K, Liou, Yae-Huei, Knudsen, Nelson H, Starost, Kyle A, Xu, Chuanrui, Hyde, Alexander L, Liu, Sihao, Jacobi, David, Liao, Nan-Shih, Lee, Chih-Hao

“…Metabolic pathways and inflammatory processes are under circadian regulation. Rhythmic immune cell recruitment is known to impact infection outcomes, but…”
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Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway by Xiang, Ming, Liu, Tingting, Tian, Cheng, Ma, Kun, Gou, Jing, Huang, Rongrong, Li, Senlin, Li, Qing, Xu, Chuanrui, Li, Lei, Lee, Chih-Hao, Zhang, Yonghui

“…Kinsenoside (KD) exhibits anti-inflammatory and immunosuppressive effects. Dendritic cells (DCs) are critical regulators of the pathologic inflammatory milieu…”
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Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis by Li, Bin, Chen, Yuyuan, Wang, Fei, Guo, Jun, Fu, Wen, Li, Min, Zheng, Qichang, Liu, Yong, Fan, Lingling, Li, Lei, Xu, Chuanrui

“…Bmi1 is overexpressed in one-third of hepatocellular carcinoma (HCC) patients and acts as an oncogene in hepatocarcinogenesis. However, the underlying…”
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Enhanced anti-tumor effect of liposomal Fasudil on hepatocellular carcinoma in vitro and in vivo by Zhao, Ying, Zhang, Yu, Vazirinejad Mehdiabad, Milad, Zhou, Ke, Chen, Yuyuan, Li, Lei, Guo, Jun, Xu, Chuanrui

“…Hepatocellular carcinoma (HCC) is one of the most malignant cancers and the treatment options for this disease are limited and generally not effective. ROCK…”
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Integrating bulk and single‐cell RNA sequencing reveals cellular heterogeneity and immune infiltration in hepatocellular carcinoma by Wang, Tingjie, Dang, Ningxin, Tang, Guangbo, Li, Zihang, Li, Xiujuan, Shi, Bingyin, Xu, Zhong, Li, Lei, Yang, Xiaofei, Xu, Chuanrui, Ye, Kai

“…Efficacy of immunotherapy in hepatocellular carcinoma (HCC) is blocked by its high degree of inter‐ and intra‐tumor heterogeneity and immunosuppressive tumor…”
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MicroRNA-139-5p inhibits bladder cancer proliferation and self-renewal by targeting the Bmi1 oncogene by Luo, Hongbo, Yang, Rui, Li, Chun, Tong, Yongqing, Fan, Lingling, Liu, Xiuheng, Xu, Chuanrui

“…MiR-139-5p has been reported to be overexpressed in many types of cancers, but its role in bladder cancer has not been elucidated yet. Here, we report that…”
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Optimization of immunoturbidimetric assay system enhanced by β2-microglobulin latex by Hu, Mingjie, Xu, Chuanrui, Yan, Dandan, Gao, Le, Zhang, Hao

“…In this study, three-factor and three-level orthogonal experiment was used to optimize the detection system of clinical renal function marker β2-microglobulin…”
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Nitric oxide-releasing micelles with intelligent targeting for enhanced anti-tumor effect of cisplatin in hypoxia by Chen, Yan, Fang, Lei, Zhou, Weixin, Chang, Jinghan, Zhang, Xiaojuan, He, Chuanchuan, Chen, Chen, Yan, Ruicong, Yan, Yakai, Lu, Yao, Xu, Chuanrui, Xiang, Guangya

“…Hypoxic tumor microenvironment (TME) promotes tumor metastasis and drug resistance, leading to low efficiency of cancer chemotherapy. The development of…”
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Indian Hedgehog Regulates Intestinal Stem Cell Fate Through Epithelial−Mesenchymal Interactions During Development by Kosinski, Cynthia, Stange, Daniel E, Xu, Chuanrui, Chan, Annie Sy, Ho, Coral, Yuen, Siu Tsan, Mifflin, Randy C, Powell, Don W, Clevers, Hans, Leung, Suet Yi, Chen, Xin

“…Background & Aims Intestinal stem cells (ISCs) are regulated by the mesenchymal environment via physical interaction and diffusible factors. We examined the…”
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Integrating cell interaction with transcription factors to obtain a robust gene panel for prognostic prediction and therapies in cholangiocarcinoma by Wang, Tingjie, Xu, Chuanrui, Xu, Dan, Yang, Xiaofei, Liu, Yaxin, Li, Xiujuan, Li, Zihang, Dang, Ningxin, Lv, Yi, Zhang, Zhijing, Li, Lei, Ye, Kai

“…The efficacy of immunotherapy for cholangiocarcinoma (CCA) is blocked by a high degree of tumor heterogeneity. Cell communication contributes to heterogeneity…”
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Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo by Li, Weijie, Yan, Ruicong, Liu, Yong, He, Chuanchuan, Zhang, Xiaojuan, Lu, Yao, Khan, Muhammad Waseem, Xu, Chuanrui, Yang, Tan, Xiang, Guangya

“…Overexpression of Bmi1 gene is an important feature of cancer stem cell in various human tumors. Therefore, Bmi1 gene can be a potential target for small…”
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Bmi1 is required for hepatic progenitor cell expansion and liver tumor development by Fan, Lingling, Xu, Chuanrui, Wang, Chunmei, Tao, Junyan, Ho, Coral, Jiang, Lijie, Gui, Bing, Huang, Shiang, Evert, Matthias, Calvisi, Diego F, Chen, Xin

“…Bmi1 is a polycomb group transcriptional repressor and it has been implicated in regulating self-renewal and proliferation of many types of stem or progenitor…”
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Validation of Bmi1 as a therapeutic target of hepatocellular carcinoma in mice by Qi, Shibo, Li, Bin, Yang, Tan, Liu, Yong, Cao, Shanshan, He, Xingxing, Zhang, Peng, Li, Lei, Xu, Chuanrui

“…Bmi1 is a member of the polycomb group family of proteins, and it drives the carcinogenesis of various cancers and governs the self-renewal of multiple types…”
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RNA interference as therapeutics for hepatocellular carcinoma by Xu, Chuanrui, Lee, Susie A, Chen, Xin

“…Hepatocellular carcinoma (HCC), a major form of primary liver cancer, is one of the leading causes of cancer related deaths worldwide. Hepatitis B and C…”
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A novel chenodeoxycholic acid-verticinone ester induces apoptosis and cell cycle arrest in HepG2 cells by Liang, Dong, Zhou, Qing, Zhang, Jiuliang, Gong, Wei, Xu, Chuanrui, Li, Bin, Wang, Yi, Li, Jiangtao

“…► CDCA-Ver inhibited HepG2 cell viability and induced apoptotic cell death. ► CDCA-Ver induced G0/G1 cell cycle arrest. ► We concluded that CDCA-Ver may be a…”
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Inhibition of miR-96 expression reduces cell proliferation and clonogenicity of HepG2 hepatoma cells by XU, DONG, HE, XINGXING, CHANG, YING, XU, CHUANRUI, JIANG, XIANG, SUN, SHUZHEN, LIN, JUSHENG

“…microRNAs (miRNAs) are negative regulators of gene expression and can function as tumor suppressors or oncogenes. Several miRNAs are associated with the…”
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Co-delivery of doxorubicin and Bmi1 siRNA by folate receptor targeted liposomes exhibits enhanced anti-tumor effects in vitro and in vivo by Yang, Tan, Li, Bin, Qi, Shibo, Liu, Yong, Gai, Yongkang, Ye, Peng, Yang, Guang, Zhang, Wendian, Zhang, Peng, He, Xingxing, Li, Weijie, Zhang, Zhiping, Xiang, Guangya, Xu, Chuanrui

“…Bmi1 gene overexpression is found in various human tumors and has been shown as a potential target for gene treatment. However, siRNA-based treatments…”
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Resveratrol Attenuates High-Fat Diet-Induced Hepatic Lipotoxicity by Upregulating Bmi-1 Expression by Yuan, Weigang, Zhang, Mi, Wang, Chunxu, Li, Bin, Li, Lei, Ye, Feng, Xu, Chuanrui

“…Resveratrol (RES), a natural polyphenol phytoalexin, has been reported to attenuate nonalcoholic fatty liver disease (NAFLD). However, its roles on protection…”
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Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progression by Wang, Tingjie, Xu, Chuanrui, Zhang, Zhijing, Wu, Hua, Li, Xiujuan, Zhang, Yu, Deng, Nan, Dang, Ningxin, Tang, Guangbo, Yang, Xiaofei, Shi, Bingyin, Li, Zihang, Li, Lei, Ye, Kai

“…Background and Aims Intrahepatic cholangiocarcinoma (ICC) is not fully investigated, and how stromal cells contribute to ICC formation is poorly understood. We…”
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