Search Results - "CHUAI, Shannon"

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED by Qi, Wei, Zhao, Kehao, Gu, Justin, Huang, Ying, Wang, Youzhen, Zhang, Hailong, Zhang, Man, Zhang, Jeff, Yu, Zhengtian, Li, Ling, Teng, Lin, Chuai, Shannon, Zhang, Chao, Zhao, Mengxi, Chan, HoMan, Chen, Zijun, Fang, Douglas, Fei, Qi, Feng, Leying, Feng, Lijian, Gao, Yuan, Ge, Hui, Ge, Xinjian, Li, Guobin, Lingel, Andreas, Lin, Ying, Liu, Yueqin, Luo, Fangjun, Shi, Minlong, Wang, Long, Wang, Zhaofu, Yu, Yanyan, Zeng, Jue, Zeng, Chenhui, Zhang, Lijun, Zhang, Qiong, Zhou, Shaolian, Oyang, Counde, Atadja, Peter, Li, En

“…H3K27me3 binding to the EED pocket of the Polycomb repressive complex 2 (PRC2) is required to activate PRC2. An allosteric small-molecule inhibitor of PRC2 was…”
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Intratumoral Heterogeneity of ALK-Rearranged and ALK/EGFR Coaltered Lung Adenocarcinoma by Cai, Weijing, Lin, Dongmei, Wu, Chunyan, Li, Xuefei, Zhao, Chao, Zheng, Limou, Chuai, Shannon, Fei, Ke, Zhou, Caicun, Hirsch, Fred R

“…Genetic intratumoral heterogeneity has a profound influence on the selection of clinical treatment strategies and on addressing resistance to targeted therapy…”
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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation by Qi, Wei, Chan, HoMan, Tenga, Lin, Li, Ling, Chuai, Shannon, Zhang, Ruipeng, Zeng, Jue, Li, Min, Fan, Hong, Lin, Ying, Gu, Justin, Ardayfio, Ophelia, Zhang, Ji-Hu, Yan, Xiaoxia, Fang, Jialuo, Mi, Yuan, Zhang, Man, Zhou, Tao, Feng, Grace, Chen, Zijun, Li, Guobin, Yang, Teddy, Zhao, Kehao, Liu, Xianghui, Yu, Zhengtian, Lu, Chris X., Atadja, Peter, Li, En

“…Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by…”
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Acquired MET Y1248H and D1246N Mutations Mediate Resistance to MET Inhibitors in Non-Small Cell Lung Cancer by Li, Anna, Yang, Jin-Ji, Zhang, Xu-Chao, Zhang, Zhou, Su, Jian, Gou, Lan-Ying, Bai, Yu, Zhou, Qing, Yang, Zhenfan, Han-Zhang, Han, Zhong, Wen-Zhao, Chuai, Shannon, Zhang, Qi, Xie, Zhi, Gao, Hongfei, Chen, Huajun, Wang, Zhen, Wang, Zheng, Yang, Xue-Ning, Wang, Bin-Chao, Gan, Bin, Chen, Zhi-Hong, Jiang, Ben-Yuan, Wu, Si-Pei, Liu, Si-Yang, Xu, Chong-Rui, Wu, Yi-Long

“…amplification, responsible for 20% of acquired resistance to EGFR tyrosine kinase inhibitor (TKI) in patients with advanced non-small cell lung cancer (NSCLC),…”
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Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53 by Fei, Qi, Shang, Ke, Zhang, Jianhua, Chuai, Shannon, Kong, Desheng, Zhou, Tianlun, Fu, Shijun, Liang, Ying, Li, Chong, Chen, Zhi, Zhao, Yuan, Yu, Zhengtian, Huang, Zheng, Hu, Min, Ying, Haiyan, Chen, Zhui, Zhang, Yun, Xing, Feng, Zhu, Jidong, Xu, Haiyan, Zhao, Kehao, Lu, Chris, Atadja, Peter, Xiao, Zhi-Xiong, Li, En, Shou, Jianyong

“…SETDB1 is a histone H3K9 methyltransferase that has a critical role in early development. It is located within a melanoma susceptibility locus and facilitates…”
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Monitoring of circulating tumor DNA and its aberrant methylation in the surveillance of surgical lung Cancer patients: protocol for a prospective observational study by Kang, Guannan, Chen, Kezhong, Yang, Fan, Chuai, Shannon, Zhao, Heng, Zhang, Kai, Li, Bingsi, Zhang, Zhihong, Wang, Jun

“…Detection of circulating tumor DNA (ctDNA) is a promising method for postoperative surveillance of lung cancer. However, relatively low positive rate in early…”
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Hobnail variant of papillary thyroid carcinoma: molecular profiling and comparison to classical papillary thyroid carcinoma, poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma by Teng, Lianghong, Deng, Wanglong, Lu, Junliang, Zhang, Jing, Ren, Xinyu, Duan, Huanli, Chuai, Shannon, Duan, Feidie, Gao, Wei, Lu, Tao, Wu, Huanwen, Liang, Zhiyong

“…As a rare but aggressive papillary thyroid carcinoma (PTC) variant, the genetic changes of hobnail variant of PTC (HVPTC) are still unclear. The prevalence of…”
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NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma by ZHENG HUANG, HAIPING WU, GU, Justin, MAN ZHANG, YANG, Teddy, KEHAO ZHAO, YANYAN YU, JINGQUAN DAI, WEI YI, SHAOLIAN ZHOU, QIAN LI, JING WU, SHANNON CHUAI, JUN LIU, XU WU, CHAN, Homan, LU, Chris, ATADJA, Peter, EN LI, YAN WANG, MIN HU, FIONA XU, FENG YAN, ENGLUND, Nathan, ZHAOFU WANG, HAILONG ZHANG, MING FANG, YOUZHEN WANG

“…Histone lysine methyltransferase NSD2 (WHSC1/MMSET) is overexpressed frequently in multiple myeloma due to the t(4;14) translocation associated with 15% to 20%…”
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Mutation Landscape of Homologous Recombination Repair Genes in Epithelial Ovarian Cancer in China and Its Relationship With Clinicopathlological Characteristics by Yao, Qianlan, Liu, Yanhui, Zhang, Lihua, Dong, Lin, Bao, Longlong, Bai, Qianming, Cui, Qian, Xu, Jie, Li, Min, Liu, Jing, Chuai, Shannon, Ying, Jianming, Zhang, Zhihong, Zhou, Xiaoyan

“…The status of homologous recombination repair (HRR) gene mutations and their impact on the survival of patients with Chinese epithelial ovarian cancer (EOC)…”
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Randomized multicenter feasibility trial of myofascial physical therapy for the treatment of urological chronic pelvic pain syndromes by FitzGerald, Mary P, Anderson, Rodney U, Potts, Jeannette, Payne, Christopher K, Peters, Kenneth M, Clemens, J Quentin, Kotarinos, Rhonda, Fraser, Laura, Cosby, Annemarie, Fortman, Carole, Neville, Cynthia, Badillo, Suzanne, Odabachian, Lisa, Sanfield, Andrea, O'Dougherty, Betsy, Halle-Podell, Rick, Cen, Liyi, Chuai, Shannon, Landis, J Richard, Mickelberg, Keith, Barrell, Ted, Kusek, John W, Nyberg, Leroy M

“…We determined the feasibility of conducting a randomized clinical trial designed to compare 2 methods of manual therapy (myofascial physical therapy and global…”
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Alfuzosin and Symptoms of Chronic Prostatitis–Chronic Pelvic Pain Syndrome by Nickel, J. Curtis, Krieger, John N, McNaughton-Collins, Mary, Anderson, Rodney U, Pontari, Michel, Shoskes, Daniel A, Litwin, Mark S, Alexander, Richard B, White, Paige C, Berger, Richard, Nadler, Robert, O'Leary, Michael, Liong, Men Long, Zeitlin, Scott, Chuai, Shannon, Landis, J. Richard, Kusek, John W, Nyberg, Leroy M, Schaeffer, Anthony J

“…In this multicenter, randomized, double-blind, placebo-controlled trial, treatment with the alpha-adrenergic receptor blocker alfuzosin (as compared with…”
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Global gene expression profiling of pleural mesotheliomas : Overexpression of aurora kinases and P16/CDKN2A deletion as prognostic factors and critical evaluation of microarray-based prognostic prediction by LOPEZ-RIOS, Fernando, CHUAI, Shannon, RUSCH, Valerie, OLSHEN, Adam B, LADANYI, Marc, FLORES, Raja, SHIMIZU, Shigeki, OHNO, Takatoshi, WAKAHARA, Kazuhiko, ILLEI, Peter B, HUSSAIN, Sanaa, KRUG, Lee, ZAKOWSKI, Maureen F

“…Most gene expression profiling studies of mesothelioma have been based on relatively small sample numbers, limiting their statistical power. We did Affymetrix…”
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Involvement of histone acetylation of Sox17 and Foxa2 promoters during mouse definitive endoderm differentiation revealed by microRNA profiling by Fu, Shijun, Fei, Qi, Jiang, Hua, Chuai, Shannon, Shi, Song, Xiong, Wen, Jiang, Lei, Lu, Chris, Atadja, Peter, Li, En, Shou, Jianyong

“…Generation of hepatocyte from embryonic stem cells (ESCs) holds great promise for hepatocyte replacement therapy to treat liver diseases. Achieving high…”
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Effect of Mammography on Breast Cancer Risk in Women with Mutations in BRCA1 or BRCA2 by GOLDFRANK, Deborah, CHUAI, Shannon, ROBSON, Mark, BERNSTEIN, Jonine L, Y CAJAL, Teresa Ramon, LEE, Johanna B, ALONSO, M. Carmen, DIEZ, Orland, BAIGET, Monserrat, KAUFF, Noah D, OFFIT, Kenneth

“…Women who carry mutations in either the BRCA1 or BRCA2 genes are at risk for early-onset breast cancer and are recommended to begin screening mammography at…”
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Wasting or Obesity at Time of Transplant Does Not Predict Pediatric Heart Transplant Outcomes: Analysis of ISHLT Pediatric Heart Transplant Registry by Kaufman, Beth D., MD, Chuai, Shannon, MS, Dobbels, Fabienne, PhD, Shaddy, Robert E., MD

“…Background Body mass index (BMI) both before and after heart transplant (HT) is used to risk stratify in adult HT. Single-center studies identify BMI as a…”
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Response to crizotinib in advanced ALK-rearranged non-small cell lung cancers with different ALK-fusion variants by Li, Yan, Zhang, Tongtong, Zhang, Jing, Li, Wenbin, Yuan, Pei, Xing, Puyuan, Zhang, Zhou, Chuai, Shannon, Li, Junling, Ying, Jianming

“…•Described the patterns of ALK variant in Chinese ALK-fusion NSCLCs.•Investigated the clinical outcomes among different ALK variants with crizotinib.•Variant 2…”
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Capture-Based Targeted Ultradeep Sequencing in Paired Tissue and Plasma Samples Demonstrates Differential Subclonal ctDNA-Releasing Capability in Advanced Lung Cancer by Mao, Xiaowei, Zhang, Zhou, Zheng, Xiaoxuan, Xie, Fangfang, Duan, Feidie, Jiang, Liyan, Chuai, Shannon, Han-Zhang, Han, Han, Baohui, Sun, Jiayuan

“…Circulating tumor DNA (ctDNA), which represents an unbiased way to assess tumor genetic profile noninvasively, facilitates studying intratumor heterogeneity…”
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Individualized tumor-informed circulating tumor DNA analysis for postoperative monitoring of non-small cell lung cancer by Chen, Kezhong, Yang, Fan, Shen, Haifeng, Wang, Chenyang, Li, Xi, Chervova, Olga, Wu, Shuailai, Qiu, Fujun, Peng, Di, Zhu, Xin, Chuai, Shannon, Beck, Stephan, Kanu, Nnennaya, Carbone, David, Zhang, Zhihong, Wang, Jun

“…We report a personalized tumor-informed technology, Patient-specific pROgnostic and Potential tHErapeutic marker Tracking (PROPHET) using deep sequencing of 50…”
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Combinational Analysis of FISH and Immunohistochemistry Reveals Rare Genomic Events in ALK Fusion Patterns in NSCLC that Responds to Crizotinib Treatment by Li, Wenbin, Zhang, Jing, Guo, Lei, Chuai, Shannon, Shan, Ling, Ying, Jianming

“…The purpose of this study was to explore the complicated rearrangement mechanisms underlying cases with atypical and negative anaplastic lymphoma receptor…”
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Noninvasive genotyping and monitoring of anaplastic lymphoma kinase (ALK) rearranged non-small cell lung cancer by capture-based next-generation sequencing by Wang, Ye, Tian, Pan-Wen, Wang, Wei-Ya, Wang, Ke, Zhang, Zhou, Chen, Bo-Jiang, He, Yan-Qi, Li, Lei, Liu, Hao, Chuai, Shannon, Li, Wei-Min

“…Noninvasive genotyping of driver genes and monitoring of tumor dynamics help make better personalized therapeutic decisions. However, neither PCR-based assays…”
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