Search Results - "CHU, YIWEI"

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3-CCL2 Signaling by Yang, Xuguang, Lin, Yuli, Shi, Yinghong, Li, Bingji, Liu, Weiren, Yin, Wei, Dang, Yongjun, Chu, Yiwei, Fan, Jia, He, Rui

“…Cancer-associated fibroblasts (CAF) are components of the tumor microenvironment whose contributions to malignant progression are not fully understood. Here,…”
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Lipid metabolism in inflammation-related diseases by Zhang, Cuiping, Wang, Ke, Yang, Lujie, Liu, Ronghua, Chu, Yiwei, Qin, Xue, Yang, Pengyuan, Yu, Hongxiu

“…There are thousands of lipid species existing in cells, which belong to eight different categories. Lipids are the essential building blocks of cells. Recent…”
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Strategies for overcoming bottlenecks in allogeneic CAR-T cell therapy by Lv, Zixin, Luo, Feifei, Chu, Yiwei

“…Patient-derived autologous chimeric antigen receptor (CAR)-T cell therapy is a revolutionary breakthrough in immunotherapy and has made impressive progress in…”
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The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy by Qian, Jiawen, Wang, Chen, Wang, Bo, Yang, Jiao, Wang, Yuedi, Luo, Feifei, Xu, Junying, Zhao, Chujun, Liu, Ronghua, Chu, Yiwei

“…PD-L1 is an immune inhibitory receptor ligand that leads to T cell dysfunction and apoptosis by binding to its receptor PD-1, which works in braking…”
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SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice by Wang, Fang, Wang, Ke, Xu, Wei, Zhao, Shimin, Ye, Dan, Wang, Yi, Xu, Ying, Zhou, Lisha, Chu, Yiwei, Zhang, Cuiping, Qin, Xue, Yang, Pengyuan, Yu, Hongxiu

“…LPS-activated macrophages undergo a metabolic shift from dependence on mitochondria-produced ATP to reliance on aerobic glycolysis, where PKM2 is a critical…”
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Safety and clinical efficacy of BCMA CAR-T-cell therapy in multiple myeloma by Roex, Gils, Timmers, Marijke, Wouters, Kristien, Campillo-Davo, Diana, Flumens, Donovan, Schroyens, Wilfried, Chu, Yiwei, Berneman, Zwi N, Lion, Eva, Luo, Feifei, Anguille, Sébastien

“…B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T-cell therapy is an emerging treatment option for multiple myeloma. The aim of this…”
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MicroRNA-7 inhibits the growth of human non-small cell lung cancer A549 cells through targeting BCL-2 by Xiong, Shudao, Zheng, Yijie, Jiang, Pei, Liu, Ronghua, Liu, Xiaoming, Chu, Yiwei

“…MicroRNAs(miRNAs) are emerging as important regulators in tumorigenesis. Increasing evidences have indicated microRNA-7(miR-7) to be a potential tumor…”
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β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion by Zhang, Yihua, Li, Manman, Li, Liuyan, Qian, Gui, Wang, Yu, Chen, Zijuan, Liu, Jing, Fang, Chao, Huang, Feng, Guo, Daqiao, Zou, Quanming, Chu, Yiwei, Yan, Dapeng

“…Virus infection may induce excessive interferon (IFN) responses that can lead to host tissue injury or even death. β-arrestin 2 regulates multiple cellular…”
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SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1α-Dependent Glycolysis by Liu, Guangwei, Bi, Yujing, Shen, Bo, Yang, Hui, Zhang, Yan, Wang, Xiao, Liu, Huanrong, Lu, Yun, Liao, Jiongbo, Chen, Xi, Chu, Yiwei

“…Myeloid-derived suppressor cells (MDSC) display an immature phenotype that may assume a classically activated (M1) or alternatively activated phenotype (M2) in…”
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Chemokines and receptors in intestinal B lymphocytes by Zhiming, Wang, Luman, Wang, Tingting, Qian, Yiwei, Chu

“…Recent studies indicate that chemoattractant cytokines (chemokines) and their receptors modulate intestinal B lymphocytes in different ways, including…”
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Dendritic cell SIRT1–HIF1α axis programs the differentiation of CD4⁺ T cells through IL-12 and TGF-β1 by Liu, Guangwei, Bi, Yujing, Xue, Lixiang, Zhang, Yan, Yang, Hui, Chen, Xi, Lu, Yun, Zhang, Zhengguo, Liu, Huanrong, Wang, Xiao, Wang, Ruoning, Chu, Yiwei, Yang, Ruifu

“…The differentiation of naive CD4 ⁺ T cells into distinct lineages plays critical roles in mediating adaptive immunity or maintaining immune tolerance. In…”
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Editorial: Insights into Regulatory B Cells by Wang, Luman, Xu, Damo, Chu, Yiwei

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Prognostic significance of the IASLC/ATS/ERS classification in Chinese patients-A single institution retrospective study of 292 lung adenocarcinoma by Gu, Jie, Lu, Chunlai, Guo, Jing, Chen, Lingli, Chu, Yiwei, Ji, Yuan, Ge, Di

“…Background A new classification of pulmonary adenocarcinoma has been recently proposed by the International Association for the Study of Lung Cancer, American…”
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LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma by Qian, Guojun, Jiang, Wei, Zou, Benkun, Feng, Jintao, Cheng, Xiaofang, Gu, Jie, Chu, Tianqing, Niu, Chen, He, Rui, Chu, Yiwei, Lu, Mingfang

“…Allergic asthma is a chronic inflammatory disease primarily mediated by Th2 immune mechanisms. Numerous studies have suggested that early life exposure to…”
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Optimization of T Cell Redirecting Strategies: Obtaining Inspirations From Natural Process of T Cell Activation by Gao, Yiyuan, Wang, Yuedi, Luo, Feifei, Chu, Yiwei

“…Chimeric antigen receptors (CARs) or bispecific antibodies (bsAbs) redirected T cell against tumors is one of the most promising immunotherapy approaches…”
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T follicular helper cells and regulatory B cells dynamics in systemic lupus erythematosus by Yang, Xue, Yang, Ji, Chu, Yiwei, Xue, Yu, Xuan, Dandan, Zheng, Shucong, Zou, Hejian

“…T follicular helper (Tfh) cells aid effector B cells, and augment autoimmunity, whereas the role of Tfh cells on regulatory B (Breg) cells in systemic lupus…”
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The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth by Luo, Zhongguang, Yu, Guangyang, Lee, Hyuk Woo, Li, Lihui, Wang, Lingyan, Yang, Dongqin, Pan, Yongfu, Ding, Chan, Qian, Jing, Wu, Lijun, Chu, Yiwei, Yi, Jing, Wang, Xiangdong, Sun, Yi, Jeong, Lak Shin, Liu, Jie, Jia, Lijun

“…Posttranslational neddylation of cullins in the Cullin-Ring E3 ligase (CRL) complexes is needed for proteolytic degradation of CRL substrates, whose…”
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DNMT1-microRNA126 epigenetic circuit contributes to esophageal squamous cell carcinoma growth via ADAM9-EGFR-AKT signaling by Liu, Ronghua, Gu, Jie, Jiang, Pei, Zheng, Yijie, Liu, Xiaoming, Jiang, Xuechao, Huang, Enyu, Xiong, Shudao, Xu, Fengkai, Liu, Guangwei, Ge, Di, Chu, Yiwei

“…MicroRNAs (miRNA) are involved in and are controlled by epigenetic regulation, and thereby form a reciprocal regulatory circuit. Using next-generation…”
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MiR-34a inhibits lipopolysaccharide-induced inflammatory response through targeting Notch1 in murine macrophages by Jiang, Pei, Liu, Ronghua, Zheng, Yijie, Liu, Xiaoming, Chang, Lijun, Xiong, Shudao, Chu, Yiwei

“…Inflammatory responses are complex events occurring when the host immune system fights against invading pathogens, which are double-edged swords requiring…”
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CD47 Blockade Inhibits Tumor Progression through Promoting Phagocytosis of Tumor Cells by M2 Polarized Macrophages in Endometrial Cancer by Wang, Yudong, Sun, Xiao, Huang, Ting, Wang, Yiwei, Fan, Qiong, Liu, Yao, Wang, Jing, Ni, Ting, Gu, Shenglan, Chu, Yiwei

“…There are rapidly emerging efforts to explore tumor-associated macrophages (TAMs) as a tumor therapy target. Tumor cells express CD47, which can interact with…”
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