Search Results - "CHU, Gerald C"

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer by Kapoor, Avnish, Yao, Wantong, Ying, Haoqiang, Hua, Sujun, Liewen, Alison, Wang, Qiuyun, Zhong, Yi, Wu, Chang-Jiun, Sadanandam, Anguraj, Hu, Baoli, Chang, Qing, Chu, Gerald C., Al-Khalil, Ramsey, Jiang, Shan, Xia, Hongai, Fletcher-Sananikone, Eliot, Lim, Carol, Horwitz, Gillian I., Viale, Andrea, Pettazzoni, Piergiorgio, Sanchez, Nora, Wang, Huamin, Protopopov, Alexei, Zhang, Jianhua, Heffernan, Timothy, Johnson, Randy L., Chin, Lynda, Wang, Y. Alan, Draetta, Giulio, DePinho, Ronald A.

“…Activating mutations in KRAS are among the most frequent events in diverse human carcinomas and are particularly prominent in human pancreatic ductal…”
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Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism by Biancur, Douglas E., Paulo, Joao A., Małachowska, Beata, Quiles Del Rey, Maria, Sousa, Cristovão M., Wang, Xiaoxu, Sohn, Albert S. W., Chu, Gerald C., Gygi, Steven P., Harper, J. Wade, Fendler, Wojciech, Mancias, Joseph D., Kimmelman, Alec C.

“…Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these…”
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Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism by Ying, Haoqiang, Kimmelman, Alec C., Lyssiotis, Costas A., Hua, Sujun, Chu, Gerald C., Fletcher-Sananikone, Eliot, Locasale, Jason W., Son, Jaekyoung, Zhang, Hailei, Coloff, Jonathan L., Yan, Haiyan, Wang, Wei, Chen, Shujuan, Viale, Andrea, Zheng, Hongwu, Paik, Ji-hye, Lim, Carol, Guimaraes, Alexander R., Martin, Eric S., Chang, Jeffery, Hezel, Aram F., Perry, Samuel R., Hu, Jian, Gan, Boyi, Xiao, Yonghong, Asara, John M., Weissleder, Ralph, Wang, Y. Alan, Chin, Lynda, Cantley, Lewis C., DePinho, Ronald A.

“…Tumor maintenance relies on continued activity of driver oncogenes, although their rate-limiting role is highly context dependent. Oncogenic Kras mutation is…”
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Oncogenic Kras drives invasion and maintains metastases in colorectal cancer by Boutin, Adam T, Liao, Wen-Ting, Wang, Melody, Hwang, Soyoon Sarah, Karpinets, Tatiana V, Cheung, Hannah, Chu, Gerald C, Jiang, Shan, Hu, Jian, Chang, Kyle, Vilar, Eduardo, Song, Xingzhi, Zhang, Jianhua, Kopetz, Scott, Futreal, Andrew, Wang, Y Alan, Kwong, Lawrence N, DePinho, Ronald A

“…Human colorectal cancer (CRC) is a major cause of cancer mortality and frequently harbors activating mutations in the gene. To understand the role of oncogenic…”
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Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases by Ding, Zhihu, Wu, Chang-Jiun, Jaskelioff, Mariela, Ivanova, Elena, Kost-Alimova, Maria, Protopopov, Alexei, Chu, Gerald C., Wang, Guocan, Lu, Xin, Labrot, Emma S., Hu, Jian, Wang, Wei, Xiao, Yonghong, Zhang, Hailei, Zhang, Jianhua, Zhang, Jingfang, Gan, Boyi, Perry, Samuel R., Jiang, Shan, Li, Liren, Horner, James W., Wang, Y. Alan, Chin, Lynda, DePinho, Ronald A.

“…To determine the role of telomere dysfunction and telomerase reactivation in generating pro-oncogenic genomic events and in carcinoma progression, an inducible…”
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Animal Models of Human Prostate Cancer: The Consensus Report of the New York Meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee by ITTMANN, Michael, JIAOTI HUANG, LODA, Massimo, THOMAS, George, BOROWSKY, Alexander, CARDIFF, Robert D, RADAELLI, Enrico, MARTIN, Philip, SIGNORETTI, Sabina, SULLIVAN, Ruth, SIMONS, Brian W, WARD, Jerrold M, ROBINSON, Brian D, CHU, Gerald C

“…Animal models, particularly mouse models, play a central role in the study of the etiology, prevention, and treatment of human prostate cancer. While tissue…”
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GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation by Nolan-Stevaux, Olivier, Lau, Janet, Truitt, Morgan L, Chu, Gerald C, Hebrok, Matthias, Fernández-Zapico, Martin E, Hanahan, Douglas

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by the deregulation of the hedgehog signaling pathway. The Sonic Hedgehog ligand (Shh), absent in the…”
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p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation by DePinho, Ronald A, Zheng, Hongwu, Ying, Haoqiang, Yan, Haiyan, Kimmelman, Alec C, Hiller, David J, Chen, An-Jou, Perry, Samuel R, Tonon, Giovanni, Chu, Gerald C, Ding, Zhihu, Stommel, Jayne M, Dunn, Katherine L, Wiedemeyer, Ruprecht, You, Mingjian J, Brennan, Cameron, Wang, Y. Alan, Ligon, Keith L, Wong, Wing H, Chin, Lynda

“…Glioblastoma (GBM) is a highly lethal brain tumour presenting as one of two subtypes with distinct clinical histories and molecular profiles. The primary GBM…”
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Stromal biology of pancreatic cancer by Chu, Gerald C., Kimmelman, Alec C., Hezel, Aram F., DePinho, Ronald A.

“…The genetic paradigm of cancer, focused largely on sequential molecular aberrations and associated biological impact in the neoplastic cell compartment of…”
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Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer by Bardeesy, Nabeel, Cheng, Kuang-Hung, Berger, Justin H, Chu, Gerald C, Pahler, Jessica, Olson, Peter, Hezel, Aram F, Horner, James, Lauwers, Gregory Y, Hanahan, Douglas, DePinho, Ronald A

“…SMAD4 is inactivated in the majority of pancreatic ductal adenocarcinomas (PDAC) with concurrent mutational inactivation of the INK4A/ARF tumor suppressor…”
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Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras by Friedlander, Sharon Y. Gidekel, Chu, Gerald C., Snyder, Eric L., Girnius, Nomeda, Dibelius, Gregory, Crowley, Denise, Vasile, Eliza, DePinho, Ronald A., Jacks, Tyler

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. To investigate the cellular origin(s) of this cancer, we determined the…”
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Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes by Scott, Kenneth L., Nogueira, Cristina, Heffernan, Timothy P., van Doorn, Remco, Dhakal, Sabin, Hanna, Jason A., Min, Chengyin, Jaskelioff, Mariela, Xiao, Yonghong, Wu, Chang-Jiun, Cameron, Lisa A., Perry, Samuel R., Zeid, Rhamy, Feinberg, Tamar, Kim, Minjung, Vande Woude, George, Granter, Scott R., Bosenberg, Marcus, Chu, Gerald C., DePinho, Ronald A., Rimm, David L., Chin, Lynda

“…Clinical and genomic evidence suggests that the metastatic potential of a primary tumor may be dictated by prometastatic events that have additional oncogenic…”
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Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma by Olson, Peter, Chu, Gerald C, Perry, Samuel R, Nolan-Stevaux, Olivier, Hanahan, Douglas

“…Preclinical trials in mice represent a critical step in the evaluation of experimental therapeutics. Genetically engineered mouse models (GEMMs) represent a…”
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Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation by David, Gregory, Grandinetti, Kathryn B, Finnerty, Patricia M, Simpson, Natalie, Chu, Gerald C, DePinho, Ronald A

“…The Sin3-histone deacetylase (HDAC) corepressor complex is conserved from yeast to humans. Mammals possess two highly related Sin3 proteins, mSin3A and mSin3B,…”
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Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression by Wang, Yufang, Velho, Sérgia, Vakiani, Efsevia, Peng, Shouyong, Bass, Adam J, Chu, Gerald C, Gierut, Jessica, Bugni, James M, Der, Channing J, Philips, Mark, Solit, David B, Haigis, Kevin M

“…N-RAS is one member of a family of oncoproteins that are commonly mutated in cancer. Activating mutations in NRAS occur in a subset of colorectal cancers, but…”
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Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer by Kimmelman, Alec C, Hezel, Aram F, Aguirre, Andrew J, Zheng, Hongwu, Paik, Ji-hye, Ying, Haoqiang, Chu, Gerald C, Zhang, Jean X, Sahin, Ergun, Yeo, Giminna, Ponugoti, Aditya, Nabioullin, Roustem, Deroo, Scott, Yang, Shenghong, Wang, Xiaoxu, McGrath, John P, Protopopova, Marina, Ivanova, Elena, Zhang, Jianhua, Feng, Bin, Tsao, Ming S, Redston, Mark, Protopopov, Alexei, Xiao, Yonghong, Futreal, P. Andrew, Hahn, William C, Klimstra, David S, Chin, Lynda, DePinho, Ronald A

“…Pancreas ductal adenocarcinoma (PDAC) is a highly lethal cancer that typically presents as advanced, unresectable disease. This invasive tendency, coupled with…”
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Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development by Wiedemeyer, Ruprecht, Brennan, Cameron, Heffernan, Timothy P., Xiao, Yonghong, Mahoney, John, Protopopov, Alexei, Zheng, Hongwu, Bignell, Graham, Furnari, Frank, Cavenee, Webster K., Hahn, William C., Ichimura, Koichi, Collins, V. Peter, Chu, Gerald C., Stratton, Michael R., Ligon, Keith L., Futreal, P. Andrew, Chin, Lynda

“…We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM),…”
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Ott1 (Rbm15) Is Essential for Placental Vascular Branching Morphogenesis and Embryonic Development of the Heart and Spleen by Raffel, Glen D., Chu, Gerald C., Jesneck, Jonathan L., Cullen, Dana E., Bronson, Roderick T., Bernard, Olivier A., Gilliland, D. Gary

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations by Yang, Annan, Rajeshkumar, N V, Wang, Xiaoxu, Yabuuchi, Shinichi, Alexander, Brian M, Chu, Gerald C, Von Hoff, Daniel D, Maitra, Anirban, Kimmelman, Alec C

“…Pancreatic ductal adenocarcinoma is refractory to available therapies. We have previously shown that these tumors have elevated autophagy and that inhibition…”
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Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma by Kwong, Lawrence N, Costello, James C, Liu, Huiyun, Jiang, Shan, Helms, Timothy L, Langsdorf, Aliete E, Jakubosky, David, Genovese, Giannicola, Muller, Florian L, Jeong, Joseph H, Bender, Ryan P, Chu, Gerald C, Flaherty, Keith T, Wargo, Jennifer A, Collins, James J, Chin, Lynda

“…NRAS-driven melanomas have limited therapeutic options. Combining genetically engineered models and oncogenic signaling inhibitors with rational…”
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