Search Results - "CHU, Felix"

Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth by Yakes, F Michael, Chen, Jason, Tan, Jenny, Yamaguchi, Kyoko, Shi, Yongchang, Yu, Peiwen, Qian, Fawn, Chu, Felix, Bentzien, Frauke, Cancilla, Belinda, Orf, Jessica, You, Andrew, Laird, A Douglas, Engst, Stefan, Lee, Lillian, Lesch, Justin, Chou, Yu-Chien, Joly, Alison H

“…The signaling pathway of the receptor tyrosine kinase MET and its ligand hepatocyte growth factor (HGF) is important for cell growth, survival, and motility…”
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CD8+ T cell infiltration in breast and colon cancer: A histologic and statistical analysis by Ziai, James, Gilbert, Houston N, Foreman, Oded, Eastham-Anderson, Jeffrey, Chu, Felix, Huseni, Mahrukh, Kim, Jeong M

“…The prevalence of cytotoxic tumor infiltrating lymphocytes (TILs) has demonstrated prognostic value in multiple tumor types. In particular, CD8 counts (in…”
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In vitro and in vivo activity of cabozantinib (XL184), an inhibitor of RET, MET, and VEGFR2, in a model of medullary thyroid cancer by Bentzien, Frauke, Zuzow, Marcus, Heald, Nathan, Gibson, Anna, Shi, Yongchang, Goon, Leanne, Yu, Peiwen, Engst, Stefan, Zhang, Wentao, Huang, Donghui, Zhao, Lora, Vysotskaia, Valentina, Chu, Felix, Bautista, Rajana, Cancilla, Belinda, Lamb, Peter, Joly, Alison H, Yakes, F Michael

“…A limited number of approved therapeutic options are available to metastatic medullary thyroid cancer (MTC) patients, and the response to conventional…”
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A Phase I Study of Foretinib, a Multi-Targeted Inhibitor of c-Met and Vascular Endothelial Growth Factor Receptor 2 by EDER, Joseph Paul, SHAPIRO, Geoffrey I, MCCALLUM, Stewart, HEATH, Elisabeth I, BOERNER, Scott A, LORUSSO, Patricia M, APPLEMAN, Leonard J, ZHU, Andrew X, MILES, Dale, KEER, Harold, CANCILLA, Belinda, CHU, Felix, HITCHCOCK-BRYAN, Suzanne, SHERMAN, Laurie

“…Foretinib is an oral multikinase inhibitor targeting Met, RON, Axl, and vascular endothelial growth factor receptor. We conducted a phase I,…”
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Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma by Sahu, Nisebita, Chan, Emily, Chu, Felix, Pham, Thinh, Koeppen, Hartmut, Forrest, William, Merchant, Mark, Settleman, Jeff

“…Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal human diseases and remains largely refractory to available drug treatments. Insufficient…”
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The Selective PI3K Inhibitor XL147 (SAR245408) Inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models by Foster, Paul, Yamaguchi, Kyoko, Hsu, Pin P, Qian, Fawn, Du, Xiangnan, Wu, Jianming, Won, Kwang-Ai, Yu, Peiwen, Jaeger, Christopher T, Zhang, Wentao, Marlowe, Charles K, Keast, Paul, Abulafia, Wendy, Chen, Jason, Young, Jenny, Plonowski, Artur, Yakes, F Michael, Chu, Felix, Engell, Kelly, Bentzien, Frauke, Lam, Sanh T, Dale, Stephanie, Yturralde, Olivia, Matthews, David J, Lamb, Peter, Laird, A Douglas

“…Dysregulation of PI3K/PTEN pathway components, resulting in hyperactivated PI3K signaling, is frequently observed in various cancers and correlates with tumor…”
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Immunohistochemical Detection of FLAG-Tagged Endogenous Proteins in Knock-In Mice by Ferrando, Ronald E., Newton, Kim, Chu, Felix, Webster, Joshua D., French, Dorothy M.

“…With recent advances in immunohistochemical (IHC) techniques, immunohistochemistry now plays a more important role in research, especially in mouse models…”
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Inhibition of the T790M Gatekeeper Mutant of the Epidermal Growth Factor Receptor by EXEL-7647 by GENDREAU, Steven B, VENTURA, Richard, JACKMAN, Lisa, YONGCHANG SHI, PEIWEN YU, JING WANG, AFTAB, Dana T, JAEGER, Christopher T, MEYER, Stephanie M, DE COSTA, Anushka, ENGELL, Kelly, CHEN, Jason, KEAST, Paul, MARTINI, Jean-Francois, JOLY, Alison H, LAIRD, A. Douglas, YAKES, F. Michael, WENTAO ZHANG, BENTZIEN, Frauke, CANCILLA, Belinda, LUTMAN, Jeffery, CHU, Felix

“…Purpose: Agents inhibiting the epidermal growth factor receptor (EGFR) have shown clinical benefit in a subset of non–small cell lung cancer patients…”
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689 ATRC-101 Drives Potent Single-Agent Activity in Mouse Syngeneic Tumor Models via a Novel Cellular Mechanism of Action by Leung, Yvonne, Vad, Nikhil, Ye, Anne, Santos, Daniel, Cao, Wei, Czupalla, Cathrin, Vivian, John, Williams, Carlene, Sapugay, Judevin, Harbell, Michael, Lippow, Shaun, Carroll, Chantia, Kates, Lance, Haugen, Benjamin, Bolton, Gary, Armanini, Mark, Aydin, Iraz, Whidden, Mark, Velasco-Delgado, Mauricio, Chu, Felix, Wechsler, Erin, Nguyen, Ngan, Robinson, William, Serafini, Tito, Emerling, Daniel, Greenberg, Norman, Manning-Bog, Amy, Scholz, Alexander

“…BackgroundWe have previously demonstrated adaptive antibody responses targeting public tumor antigens in cancer patients. ATRC-101, a clinical stage,…”
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Cerebrospinal fluid rhinorrhea: diagnosis and management by Kerr, Julie T, Chu, Felix W K, Bayles, Stephen W

“…Advances in imaging and endoscopic techniques have improved the ability to diagnose, localize, and treat in a less morbid fashion CSF leaks of the anterior…”
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Non-progressing cancer patients have persistent B cell responses expressing shared antibody paratopes that target public tumor antigens by DeFalco, Jeff, Harbell, Michael, Manning-Bog, Amy, Baia, Gilson, Scholz, Alexander, Millare, Beatriz, Sumi, May, Zhang, Danhui, Chu, Felix, Dowd, Christine, Zuno-Mitchell, Patricia, Kim, Dongkyoon, Leung, Yvonne, Jiang, Shuwei, Tang, Xiaobin, Williamson, Kevin S., Chen, Xiaomu, Carroll, Sean M., Espiritu Santo, Gregg, Haaser, Nicole, Nguyen, Ngan, Giladi, Eldar, Minor, David, Tan, Yann Chong, Sokolove, Jeremy B., Steinman, Lawrence, Serafini, Tito A., Cavet, Guy, Greenberg, Norman M., Glanville, Jacob, Volkmuth, Wayne, Emerling, Daniel E., Robinson, William H.

“…There is significant debate regarding whether B cells and their antibodies contribute to effective anti-cancer immune responses. Here we show that patients…”
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Technocracy or transformation? Mapping women's policy agencies and orienting gender (in)equality in the Canadian provinces by Paterson, Stephanie, Marier, Patrik, Chu, Felix

“…Canadian gender equality policy has taken a “technocratic turn” that favours bureaucratic expertise to monitor and measure (in)equality rather than…”
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Librarian-faculty relations in collection development by Chu, Felix T.

“…This study addresses the relationship between librarians and faculty regarding collection development. Data are examined in light of existing studies on…”
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Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain by Newton, Kim, Dugger, Debra L., Sengupta-Ghosh, Arundhati, Ferrando, Ronald E., Chu, Felix, Tao, Janet, Lam, Wendy, Haller, Susan, Chan, Sara, Sa, Susan, Dunlap, Debra, Eastham-Anderson, Jeffrey, Ngu, Hai, Hung, Jeffrey, French, Dorothy M., Webster, Joshua D., Bolon, Brad, Liu, Jinfeng, Reja, Rohit, Kummerfeld, Sarah, Chen, Ying-Jiun, Modrusan, Zora, Lewcock, Joseph W., Dixit, Vishva M.

“…The E3 ubiquitin ligase CRL4COP1/DET1 is active in the absence of ERK signaling, modifying the transcription factors ETV1, ETV4, ETV5, and c-JUN with…”
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Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway by Yu, Peiwen, Laird, A Douglas, Du, Xiangnan, Wu, Jianming, Won, Kwang-Ai, Yamaguchi, Kyoko, Hsu, Pin Pin, Qian, Fawn, Jaeger, Christopher T, Zhang, Wentao, Buhr, Chris A, Shen, Paula, Abulafia, Wendy, Chen, Jason, Young, Jenny, Plonowski, Arthur, Yakes, F Michael, Chu, Felix, Lee, Michelle, Bentzien, Frauke, Lam, Sanh Tan, Dale, Stephanie, Matthews, David J, Lamb, Peter, Foster, Paul

“…Activation of the PI3K (phosphoinositide 3-kinase) pathway is a frequent occurrence in human tumors and is thought to promote growth, survival, and resistance…”
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Chronic Sulforaphane Application Does Not Induce Resistance in Renal Cell Carcinoma Cells by Rutz, Jochen, Juengel, Eva, Euler, Stephanie, Maxeiner, Sebastian, Justin, Saira, Roos, Frederik, Chun, Felix K-H, Blaheta, Roman A

“…Since the natural compound sulforaphane (SFN) has been shown to stop tumor growth, renal cell carcinoma (RCC) patients often use this drug in addition to their…”
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Abstract 1543: Discovery of antibodies for ADC therapy from cancer patients who show durable clinical response to checkpoint inhibitors by Scholz, Alexander, Aurellano, Jerald, Harbell, Michael, Zhang, Danhui, O'Connor, Samantha, Millare, Beatriz, Chu, Felix, Fernandez, Sheila, Czupalla, Cathrin J., Aydin, Iraz, Manning-Bog, Amy, Leung, Yvonne, Williamson, Kevin, Carroll, Chantia, Kim, Dongkyoon, Chen, Xiaomu, Carroll, Sean M., Dhawan, Ish, Nguyen, Ngan, Thyagarajan, Shweta, Whidden, Mark, Santo, Gregg Espiritu, Haaser, Nicole, Cavet, Guy, Steinman, Lawrence, Serafini, Tito A., Volkmuth, Wayne, Benjamin, Jonathan, Robinson, William H., Greenberg, Norman M., Emerling, Daniel, DeFalco, Jeff

“…Abstract Successful anti-tumor therapy using antibody-drug conjugates (ADCs) depends, in part, on antibodies that bind tumor selective targets that are…”
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Impact on immune effectors of anti-tumor antibodies isolated from cancer patients by Manning-Bog, Amy, Baia, Gilson, Defalco, Jeff, Aydin, Iraz T, Harbell, Michael G, Zuno-Mitchell, Patricia, Sapugay, Judevin Lugar, Zhang, Danhui, Chu, Felix, Millare, Beatriz, Scholz, Alexander, Sumi, May, Fernandez, Sheila, Haaser, Nicole, Benjamin, Jonathan Eliot, Nguyen, Ngan, Volkmuth, Wayne, Robinson, William H., Greenberg, Norman M, Emerling, Daniel

“…Abstract only…”
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Anti-tumor immune responses in metastatic breast cancer exceptional responder patients by Mamchak, Alusha A, Nguyen, Ngan, Zhang, Danhui, Chu, Felix, Harbell, Michael G, Millare, Beatriz, Williamson, Kevin S, Jiang, Shuwei, Kim, Dongkyoon, Reponen, Sini, Carroll, Sean, Haaser, Nicole, Hippely, Sarah, Levin, Maren K., Manning-Bog, Amy, Defalco, Jeff, Emerling, Daniel, Greenberg, Norman M, Cavet, Guy, O'Shaughnessy, Joyce

“…Abstract only…”
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Abstract 3966: Mining the cancer immuno-responsome: The identification of functional antitumor antibodies from patients receiving checkpoint inhibitors by Baia, Gilson, Manning-Bog, Amy, Scholz, Alexander, DeFalco, Jeff, Harbell, Michael, Zhang, Danhui, Chu, Felix, Millare, Beatriz, Sumi, May, Zuno, Patricia, Sapugay, Judevin Lugar, Kim, Dongkyoon, Leung, Yvonne, Jiang, Shuwei, Tang, Xiaobin, Williamson, Kevin, Chen, Xiaomu, Carroll, Sean, Dowd, Christine, Dhawan, Ish, Benjamin, Jonathan, Santo, Gregg Espiritu, Haaser, Nicole, Nguyen, Ngan, Giladi, Eldar, Minor, David, Tan, Yann Chong, Sokolove, Jeremy B., Steinman, Lawrence, Serafini, Tito, Cavet, Guy, Greenberg, Norman M., Glanville, Jacob, Volkmuth, Wayne, Emerling, Daniel E., Robinson, William H.

“…Abstract Background: The role of B cells and antibodies in anticancer immune responses may correlate with improved prognosis in several types of cancer…”
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