Search Results - "CHRISTOPHERSON, R. I"

Phenotypic protein profiling of different B cell sub-populations using antibody CD-microarrays by Ellmark, P, Högerkorp, C.M, Ek, S, Belov, L, Berglund, M, Rosenquist, R, Christopherson, R.I, Borrebaeck, C.A.K

“…Abstract Antibody microarrays enable extensive protein expression profiling, and provide a valuable complement to DNA microarray-based gene expression…”
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Accumulation of 5-phosphoribosyl-1-pyrophosphate in human CCRF-CEM leukaemia cells treated with antifolates by Kamal, M.A., Christopherson, R.I.

“…Amido phosphoribosyltransferase (APRT) catalyzes the first step of the de novo biosynthesis of purine nucleotides, the conversion of…”
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Multiple forms of nuclear p53 formed in human Raji and MEC1 cells treated with fludarabine by Henrich, S, Christopherson, R I

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P17.54 NOVEL PROTEINS ASSOCIATED WITH INVADOPODIA STRUCTURES IN GLIOBLASTOMA MULTIFORME by Mallawaaratchy, D. M., McDonald, K. L., Sykes, E. K., Buckland, M. E., Christopherson, R. I., Kaufman, K. L.

“…Glioblastoma multiforme (GBM) tumours are diffusely infiltrative making surgical resection virtually impossible. Invasion of brain parenchyma is facilitated by…”
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Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrug-resistant human CCRF-CEM leukaemia cells by SYED, S. K, CHRISTOPHERSON, R. I, ROUFOGALIS, B. D

“…The mechanism of action of 2-chlorpromazine (2-chloro-10-(3-dimethylaminopropyl)-phenothiazine) as a reversal agent for P-glycoprotein-mediated multidrug…”
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P17.47 COMPREHENSIVE PROTEOMIC PROFILING OF BEVACIZUMAB-RESISTANT GLIOBLASTOMA MULTIFORME by Kaufman, K. L., Ly, L., McKay, M., Mallawaaratchy, D. M., Mactier, S., Crossett, B., Molloy, M., Buckland, M. E., McDonald, K. L., Christopherson, R. I.

“…Drugs that impair tumour angiogenesis, i.e. therapeutic antibody anti-vascular endothelial growth factor, bevacizumab (BEV), are becoming standard therapy for…”
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Immunophenotyping of leukemias using a cluster of differentiation antibody microarray by Belov, L, de la Vega, O, dos Remedios, C G, Mulligan, S P, Christopherson, R I

“…Different leukemias express on their plasma membranes particular subsets of the 247 defined cluster of differentiation (CD) antigens, which may resemble those…”
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B-RAF: A contributor to the melanoma phenotype by Heath, E.M.L., Kaufman, K.L., Christopherson, R.I.

“…B-RAF, a serine–threonine protein kinase, is one of the three RAF paralogs in humans. B-RAF participates in the RAS-RAF-MEK-ERK pathway, a conserved protein…”
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Cloning and Expression of Malarial Pyrimidine Enzymes by Christopherson, R. I., Cinquin, O., Shojaei, M., Kuehn, D., Menz, R. I.

“…We have cloned genes encoding three enzymes of the de novo pyrimidine pathway using genomic DNA from Plasmodium falciparum and sequence information from the…”
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Antifolates induce inhibition of amido phosphoribosyltransferase in leukemia cells by SANT, M. E, LYONS, S. D, PHILLIPS, L, CHRISTOPHERSON, R. I

“…The pathway for de novo biosynthesis of purine nucleotides contains two one-carbon transfer reactions catalyzed by glycinamide ribotide (GAR) and…”
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Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia by LYONS, S. D, SANT, M. E, CHRISTOPHERSON, R. I

“…The glutamine antagonists, acivicin (NSC 163501), azaserine (NSC 742), and 6-diazo-5-oxo-L-norleucine (DON) (NSC 7365), are potent inhibitors of many…”
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Identification of repertoires of surface antigens on leukemias using an antibody microarray by Belov, Larissa, Huang, Pauline, Barber, Nicole, Mulligan, Stephen P., Christopherson, Richard I.

“…We have previously described a microarray of cluster of differentiation (CD) antibodies that enables concurrent determination of more than 60 CD antigens on…”
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Antibody arrays: an embryonic but rapidly growing technology by Lal, Sean P., Christopherson, Richard I., dos Remedios, Cristobal G.

“…Protein arrays are now an attractive proposition as they can measure a diverse range of protein interactions not possible with traditional DNA arrays. Antibody…”
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Synthesis and Enzymic Evaluation of 4-Mercapto-6-oxo-1,4-azaphosphinane-2-carboxylic Acid 4-Oxide as an Inhibitor of Mammalian Dihydroorotase by Manthey, Michael K, Huang, Danny T. C, Bubb, William A, Christopherson, Richard I

“…The design, synthesis, and enzymic evaluation of cis- and trans-4-mercapto-6-oxo-1,4-azaphosphinane-2-carboxylic acid 4-oxide 5 against mammalian…”
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Effects of dual combinations of antifolates with atovaquone or dapsone on nucleotide levels in Plasmodium falciparum by Yeo, Anthony E.T., Seymour, Kristen K., Rieckmann, Karl H., Christopherson, Richard I.

“…The triazine antifolates, cycloguanil and 4,6-diamino-l,2-dihydro-2,2-dimethyl-l-[(2,4,5-trichlorophenoxy)propyloxy]-l,3,5-triazine hydrobromide (WR99210), and…”
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Screening microarrays of novel monoclonal antibodies for binding to T-, B- and myeloid leukaemia cells by Belov, Larissa, Huang, Pauline, Chrisp, Jeremy S., Mulligan, Stephen P., Christopherson, Richard I.

“…We have developed a microarray (DotScan) that enables rapid immunophenotyping and classification of leukaemias and lymphomas by measuring the capture of cells…”
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Fludarabine Induces Differential Expression of Proteins in Human Leukemia and Lymphoma Cells by Henrich, S., Gez, S., Crossett, B., Mulligan, S. P., Christopherson, R. I.

“…The purine analog fludarabine (FdAMP) is widely used for chemotherapy of B-lymphoid malignancies, and multiple mechanisms of action leading to apoptosis have…”
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Metabolism of adenosine and deoxyadenosine by human erythrocytes and CCRF-CEM leukemia cells by Szabados, Eve, Duggleby, Ronald G., Christopherson, Richard I.

“…Human lymphocytes lacking adenosine deaminase die and T-cell leukemias are killed by deoxycoformycin (dCf), an inhibitor of adenosine deaminase, due to…”
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Effects of acivicin and dichloroallyl lawsone upon pyrimidine biosynthesis in mouse L1210 leukemia cells by Kemp, A J, Lyons, S D, Christopherson, R I

“…Acivicin (NSC 163501) and dichloroallyl lawsone (NSC 126771) are potent inhibitors of nucleotide biosynthesis with consequent anti-cancer activity against…”
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Identification of the replication terminator protein binding sites in the terminus region of the Bacillus subtilis chromosome and stoichiometry of the binding by Lewis, P J, Ralston, G B, Christopherson, R I, Wake, R G

“…DNase I footprinting of the interaction between the replication terminator protein (RTP) of Bacillus subtilis and the inverted repeat region (IRR) at the…”
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