Search Results - "CHRISTOPHER, Lisa J"

Effects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor by Perera, Vidya, Wang, Zhaoqing, Lubin, Susan, Christopher, Lisa J., Chen, Wei, Xu, Sophia, Seiffert, Dietmar, DeSouza, Mary, Murthy, Bindu

“…Milvexian (BMS-986177/JNJ-70033093) is a potent, oral small molecule that inhibits the active form of factor XI with high affinity and selectivity. This study…”
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Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression by Shen, Hong, Liu, Tongtong, Morse, Bridget L, Zhao, Yue, Zhang, Yueping, Qiu, Xi, Chen, Cliff, Lewin, Anne C, Wang, Xi-Tao, Liu, Guowen, Christopher, Lisa J, Marathe, Punit, Lai, Yurong

“…The contribution of organic anion transporter OAT2 (SLC22A7) to the renal tubular secretion of creatinine and its exact localization in the kidney are…”
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Absolute oral bioavailability of milvexian spray‐dried dispersion formulation under fasted and fed conditions in healthy adult participants: An intravenous microtracer approach by Jarugula, Praneeth, Soleman, Sharif, Back, Hyunmoon, Christopher, Lisa J., Hawthorne, Dara, Aronson, Ronald, Bui, Anh, Mirzac, Angela, Ajavon‐Hartmann, Antoinette, Perera, Vidya, Murthy, Bindu, Merali, Samira

“…Milvexian is an oral, small‐molecule factor XIa inhibitor being developed to prevent thromboembolic events. This study assessed the absolute bioavailability…”
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Metabolism and Disposition of Dasatinib after Oral Administration to Humans by Lisa J. Christopher, Donghui Cui, Chiyuan Wu, Roger Luo, James A. Manning, Samuel J. Bonacorsi, Michael Lago, Alban Allentoff, Francis Y. F. Lee, Betty McCann, Susan Galbraith, Donald P. Reitberg, Kan He, Anthony Barros, Jr, Anne Blackwood-Chirchir, W. Griffith Humphreys, Ramaswamy A. Iyer

“…SPRYCEL (dasatinib, BMS-354825; Bristol-Myers Squibb, Princeton, NJ), a multiple kinase inhibitor, is currently approved to treat chronic myelogenous leukemia…”
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Pharmacokinetics of the Dipeptidyl Peptidase 4 Inhibitor Saxagliptin in Rats, Dogs, and Monkeys and Clinical Projections by FURA, Aberra, KHANNA, Ashish, HUMPHREYS, W. Griffith, KIRBY, Mark, VYAS, Viral, KOPLOWITZ, Barry, CHANG, Shu-Ying, CAPORUSCIO, Christian, BOULTON, David W, CHRISTOPHER, Lisa J, CHADWICK, Kristina D, HAMANN, Lawrence G

“…Saxagliptin is a potent, selective, reversible dipeptidyl peptidase 4 (DPP4) inhibitor specifically designed for extended inhibition of the DPP4 enzyme and is…”
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Identification of the Human Enzymes Involved in the Oxidative Metabolism of Dasatinib: An Effective Approach for Determining Metabolite Formation Kinetics by LIFEI WANG, CHRISTOPHER, Lisa J, DONGHUI CUI, WENYING LI, IYER, Ramaswamy, HUMPHREYS, W. Griffith, DONGLU ZHANG

“…N -(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide (dasatinib, Sprycel, BMS-354825;…”
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Lacteal Secretion, Fetal and Maternal Tissue Distribution of Dasatinib in Rats by KAN HE, LAGO, Michael W, IYER, Ramaswamy A, SHYU, Wen-Chyi, HUMPHREYS, William G, CHRISTOPHER, Lisa J

“…Dasatinib [ N -(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide; BMS-354825] is a potent…”
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Prediction of drug–drug interaction potential mediated by transporters between dasatinib and metformin, pravastatin, and rosuvastatin using physiologically based pharmacokinetic modeling by Chang, Ming, Bathena, Sai, Christopher, Lisa J., Shen, Hong, Roy, Amit

“…Purpose Recent in vitro studies demonstrated that dasatinib inhibits organic cation transporter 2 (OCT2), multidrug and toxin extrusion proteins (MATEs), and…”
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Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans by Ahire, Deepak, Basit, Abdul, Christopher, Lisa J, Iyer, Ramaswamy, Leeder, J Steven, Prasad, Bhagwat

“…Mitochondrial amidoxime-reducing component (mARC) enzymes are molybdenum-containing proteins that metabolize a number of endobiotics and xenobiotics. The…”
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In Vitro Characterization of the Metabolic Pathways and Cytochrome P450 Inhibition and Induction Potential of BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor by HAIZHENG HONG, HONG SU, LI MA, MING YAO, IYER, Ramaswamy A, HUMPHREYS, W. Griffith, CHRISTOPHER, Lisa J

“…(3R,4R)-4-Amino-1-((4-((3-methoxyphenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)methyl)-3-piperidinol (BMS-690514) is a potent inhibitor of ErbB human…”
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Biotransformation of [14C]Dasatinib: In Vitro Studies in Rat, Monkey, and Human and Disposition after Administration to Rats and Monkeys by Lisa J. Christopher, Donghui Cui, Wenying Li, Anthony Barros, Jr, Vinod K. Arora, Haiying Zhang, Lifei Wang, Donglu Zhang, James A. Manning, Kan He, Anthony M. Fletcher, Marc Ogan, Michael Lago, Samuel J. Bonacorsi, W. Griffith Humphreys, Ramaswamy A. Iyer

“…This study describes the in vitro metabolism of [ 14 C]dasatinib in liver tissue incubations from rat, monkey, and human and the in vivo metabolism in rat and…”
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The Importance of Tracking “Missing” Metabolites: How and Why? by Wang, Shuai, Ballard, T. Eric, Christopher, Lisa J., Foti, Robert S., Gu, Chungang, Khojasteh, S. Cyrus, Liu, Joyce, Ma, Shuguang, Ma, Bin, Obach, R. Scott, Schadt, Simone, Zhang, Zhoupeng, Zhang, Donglu

“…Technologies currently employed to find and identify drug metabolites in complex biological matrices generally yield results that offer a comprehensive picture…”
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Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein-Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo by Zhang, Yueping, Shipkova, Petia A, Warrack, Bethanne M, Nelson, David M, Wang, Linna, Huo, Runlan, Chen, Jian, Panfen, Erika, Chen, Xue-Qing, Fancher, R Marcus, Ruan, Qian, Christopher, Lisa J, Xue, Yongjun, Sinz, Michael, Shen, Hong

“…Advancement of endogenous biomarkers for drug transporters as a tool for assessing drug-drug interactions (DDIs) depends on initial identification of biomarker…”
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Hepatocyte spheroids as a viable in vitro model for recapitulation of complex in vivo metabolism pathways of loratadine in humans by Chacko, Silvi A., Ly, Van T., Christopher, Lisa J., Gan, Jinping

“…Accurate prediction of in vivo metabolic pathways in humans can be challenging because in vitro liver matrices may fail to produce certain in vivo metabolites…”
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Simultaneous oral therapeutic and intravenous 14C‐microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin by Boulton, David W., Kasichayanula, Sreeneeranj, Keung, Chi Fung (Anther), Arnold, Mark E., Christopher, Lisa J., Xu, Xiaohui (Sophia), LaCreta, Frank

“…Aim To determine the absolute oral bioavailability (Fp.o.) of saxagliptin and dapagliflozin using simultaneous intravenous 14C‐microdose/therapeutic oral…”
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Effects of Itraconazole and Diltiazem on the Pharmacokinetics and Pharmacodynamics of Milvexian, A Factor XIa Inhibitor by Perera, Vidya, Wang, Zhaoqing, Lubin, Susan, Christopher, Lisa J., Chen, Wei, Xu, Sophia, Seiffert, Dietmar, DeSouza, Mary, Murthy, Bindu

“…Introduction Modulation of Factor XIa (FXIa) may provide a novel mechanism for systemic anticoagulation with the potential to improve the risk-benefit profile…”
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Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor by Chacko, Silvi A., Yang, Wu, Wang, Yufeng, Tian, Yuan, Hong, Yang, Wallace, Michael, Wang, Bonnie, Ewing, William R., Luettgen, Joseph M., Shu, Yue-Zhong, Christopher, Lisa J.

“…FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species. The objectives of this study…”
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Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human by Su, Hong, Boulton, David W, Barros, Jr, Anthony, Wang, Lifei, Cao, Kai, Bonacorsi, Jr, Samuel J, Iyer, Ramaswamy A, Humphreys, W Griffith, Christopher, Lisa J

“…Saxagliptin is a potent dipeptidyl peptidase-4 inhibitor approved for the treatment of type 2 diabetes mellitus. The pharmacokinetics and disposition of…”
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A validated LC-MS/MS method for the quantitative measurement of creatinine as an endogenous biomarker in human plasma by Zhao, Yue, Liu, Guowen, Angeles, Aida, Christopher, Lisa J, Wang, Zhaoqing, Arnold, Mark E, Shen, Jim X

“…Creatinine is an endogenous compound generated from creatine by normal muscular metabolism. It is an important indicator of renal function and the serum level…”
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Liquid chromatography and tandem mass spectrometry method for the quantitative determination of saxagliptin and its major pharmacologically active 5-monohydroxy metabolite in human plasma: Method validation and overcoming specific and non-specific binding at low concentrations by Xu, Xiaohui (Sophia), Demers, Roger, Gu, Huidong, Christopher, Lisa J., Su, Hong, Cojocaru, Laura, Boulton, David W., Kirby, Mark, Stouffer, Bruce, Humphreys, William G., Arnold, Mark E.

“…► A liquid chromatography and tandem mass spectrometry (LC–MS/MS) method was developed and validated to simultaneously determine the concentrations of…”
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