Search Results - "CHOUKRI BEN MAMOUN"

Redesigning therapies for pantothenate kinase–associated neurodegeneration by Munshi, Muhammad I., Yao, Sarah J., Ben Mamoun, Choukri

“…Pantothenate kinase–associated neurodegeneration (PKAN) is an incurable rare genetic disorder of children and young adults caused by mutations in the PANK2…”
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Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies by Abraham, Amanah, Brasov, Ioana, Thekkiniath, Jose, Kilian, Nicole, Lawres, Lauren, Gao, Ruiyi, DeBus, Kai, He, Lan, Yu, Xue, Zhu, Guan, Graham, Morven M., Liu, Xinran, Molestina, Robert, Ben Mamoun, Choukri

“…Human babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the genus Babesia. Clinical cases caused by Babesia duncani have been…”
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The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching by Schneider, Victoria M, Visone, Joseph E, Harris, Chantal T, Florini, Francesca, Hadjimichael, Evi, Zhang, Xu, Gross, Mackensie R, Rhee, Kyu Y, Ben Mamoun, Choukri, Kafsack, Björn F C, Deitsch, Kirk W

“…The primary antigenic and virulence determinant of the human malaria parasite is a variant surface protein called PfEMP1. Different forms of PfEMP1 are encoded…”
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Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti by Cornillot, Emmanuel, Hadj-Kaddour, Kamel, Dassouli, Amina, Noel, Benjamin, Ranwez, Vincent, Vacherie, Benoît, Augagneur, Yoann, Brès, Virginie, Duclos, Aurelie, Randazzo, Sylvie, Carcy, Bernard, Debierre-Grockiego, Françoise, Delbecq, Stéphane, Moubri-Ménage, Karina, Shams-Eldin, Hosam, Usmani-Brown, Sahar, Bringaud, Frédéric, Wincker, Patrick, Vivarès, Christian P, Schwarz, Ralph T, Schetters, Theo P, Krause, Peter J, Gorenflot, André, Berry, Vincent, Barbe, Valérie, Ben Mamoun, Choukri

“…We have sequenced the genome of the emerging human pathogen Babesia microti and compared it with that of other protozoa. B. microti has the smallest nuclear…”
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Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone by Lawres, Lauren A, Garg, Aprajita, Kumar, Vidya, Bruzual, Igor, Forquer, Isaac P, Renard, Isaline, Virji, Azan Z, Boulard, Pierre, Rodriguez, Eduardo X, Allen, Alexander J, Pou, Sovitj, Wegmann, Keith W, Winter, Rolf W, Nilsen, Aaron, Mao, Jialing, Preston, Douglas A, Belperron, Alexia A, Bockenstedt, Linda K, Hinrichs, David J, Riscoe, Michael K, Doggett, J Stone, Ben Mamoun, Choukri

“…Human babesiosis is a tick-borne multisystem disease caused by Babesia species of the apicomplexan phylum. Most clinical cases and fatalities of babesiosis are…”
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Selection and identification of a precocious line of Eimeria intestinalis with enlarged oocysts and deletion of one generation of schizogony by Li, Chao, Tao, Geru, Gu, Xiaolong, Cui, Yujuan, Wang, Yunzhou, Suo, Jingxia, Lv, Yanli, Yu, Fang, Mamoun, Choukri Ben, Suo, Xun, Liu, Xianyong

“…Rabbit coccidiosis is a common parasitic disease and responsible for enormous economic losses in the rabbit industry. Eimeria intestinalis , one of the highly…”
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FT-GPI, a highly sensitive and accurate predictor of GPI-anchored proteins, reveals the composition and evolution of the GPI proteome in Plasmodium species by Sauer, Lena M, Canovas, Rodrigo, Roche, Daniel, Shams-Eldin, Hosam, Ravel, Patrice, Colinge, Jacques, Schwarz, Ralph T, Ben Mamoun, Choukri, Rivals, Eric, Cornillot, Emmanuel

“…Protozoan parasites are known to attach specific and diverse group of proteins to their plasma membrane via a GPI anchor. In malaria parasites, GPI-anchored…”
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Sequence and annotation of the apicoplast genome of the human pathogen Babesia microti by Garg, Aprajita, Stein, Anna, Zhao, William, Dwivedi, Ankit, Frutos, Roger, Cornillot, Emmanuel, Ben Mamoun, Choukri

“…The apicomplexan intraerythrocytic parasite Babesia microti is an emerging human pathogen and the primary cause of human babesiosis, a malaria-like illness…”
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Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum by Augagneur, Yoann, Wesolowski, Donna, Tae, Hyun Seop, Altman, Sidney, Ben Mamoun, Choukri

“…Unique peptide-morpholino oligomer (PMO) conjugates have been designed to bind and promote the cleavage of specific mRNA as a tool to inhibit gene function and…”
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Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum by Garg, Aprajita, Wesolowski, Donna, Alonso, Dulce, Deitsch, Kirk W, Ben Mamoun, Choukri, Altman, Sidney

“…Identification and genetic validation of new targets from available genome sequences are critical steps toward the development of new potent and selective…”
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Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission by Bobenchik, April M., Witola, William H., Augagneur, Yoann, Lochlainn, Laura Nic, Garg, Aprajita, Pachikara, Niseema, Choi, Jae-Yeon, Zhao, Yang O., Usmani-Brown, Sahar, Lee, Albert, Adjalley, Sophie H., Samanta, Swapna, Fidock, David A., Voelker, Dennis R., Fikrig, Erol, Ben Mamoun, Choukri

“…Efficient transmission of Plasmodium species between humans and Anopheles mosquitoes is a major contributor to the global burden of malaria. Gametocytogenesis,…”
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Babesia duncani in Culture and in Mouse (ICIM) Model for the Advancement of Babesia Biology, Pathogenesis, and Therapy by Kumari, Vandana, Pal, Anasuya C, Singh, Pallavi, Mamoun, Choukri Ben

“…Babesiosis is a tick-borne disease caused by pathogens belonging to the genus Babesia. In humans, the disease presents as a malaria-like illness and can be…”
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Babesia microti from humans and ticks hold a genomic signature of strong population structure in the United States by Carpi, Giovanna, Walter, Katharine S, Mamoun, Choukri Ben, Krause, Peter J, Kitchen, Andrew, Lepore, Timothy J, Dwivedi, Ankit, Cornillot, Emmanuel, Caccone, Adalgisa, Diuk-Wasser, Maria A

“…Babesia microti is an emerging tick-borne apicomplexan parasite with increasing geographic range and incidence in the United States. The rapid expansion of B…”
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Targeting the lipid metabolic pathways for the treatment of malaria by Ben Mamoun, Choukri, Prigge, Sean T., Vial, Henri

“…The control and eventual eradication of human malaria is considered one of the most important global public health goals of the 21st Century. Malaria, caused…”
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Whole genome mapping and re-organization of the nuclear and mitochondrial genomes of Babesia microti isolates by Cornillot, Emmanuel, Dassouli, Amina, Garg, Aprajita, Pachikara, Niseema, Randazzo, Sylvie, Depoix, Delphine, Carcy, Bernard, Delbecq, Stéphane, Frutos, Roger, Silva, Joana C, Sutton, Richard, Krause, Peter J, Mamoun, Choukri Ben

“…Babesia microti is the primary causative agent of human babesiosis, an emerging pathogen that causes a malaria-like illness with possible fatal outcome in…”
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Disruption of the Plasmodium falciparum PfPMT Gene Results in a Complete Loss of Phosphatidylcholine Biosynthesis via the Serine-Decarboxylase-Phosphoethanolamine-Methyltransferase Pathway and Severe Growth and Survival Defects by Witola, William Harold, El Bissati, Kamal, Pessi, Gabriella, Xie, Changan, Roepe, Paul D., Mamoun, Choukri Ben

“…Biochemical studies in the human malaria parasite, Plasmodium falciparum, indicated that in addition to the pathway for synthesis of phosphatidylcholine from…”
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Functional analysis of Plasmodium falciparum subpopulations associated with artemisinin resistance in Cambodia by Dwivedi, Ankit, Reynes, Christelle, Kuehn, Axel, Roche, Daniel B, Khim, Nimol, Hebrard, Maxim, Milanesi, Sylvain, Rivals, Eric, Frutos, Roger, Menard, Didier, Mamoun, Choukri Ben, Colinge, Jacques, Cornillot, Emmanuel

“…Plasmodium falciparum malaria is one of the most widespread parasitic infections in humans and remains a leading global health concern. Malaria elimination…”
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The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation by Chiu, Joy E., Thekkiniath, Jose, Choi, Jae-Yeon, Perrin, Benjamin A., Lawres, Lauren, Plummer, Mark, Virji, Azan Z., Abraham, Amanah, Toh, Justin Y., Zandt, Michael Van, Aly, Ahmed S. I., Voelker, Dennis R., Mamoun, Choukri Ben

“…The biosynthesis of the major acyl carrier Coenzyme A from pantothenic acid (PA) is critical for survival of Plasmodium falciparum within human erythrocytes…”
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Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers by Stahl, Philipp, Poinsignon, Yves, Pouedras, Pascal, Ciubotaru, Vasilica, Berry, Laurence, Emu, Brinda, Krause, Peter J, Ben Mamoun, Choukri, Cornillot, Emmanuel

“…Abstract Background In 2002, a previously healthy 69-year-old man travelled to France from the United States and presented to our hospital with a febrile…”
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A Pathway for Phosphatidylcholine Biosynthesis in Plasmodium falciparum Involving Phosphoethanolamine Methylation by Pessi, Gabriella, Kociubinski, Guillermo, Ben Mamoun, Choukri, Borst, P.

“…Plasmodium falciparum is the causative agent of the most severe form of human malaria. The rapid multiplication of the parasite within human erythrocytes…”
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