Search Results - "CHOUDHURY, Somesh"

Combination of pasireotide and octreotide: effects on GH and IGF-I secretion and glucose metabolism in healthy volunteers by Tauchmanova, Libuse, Breitschaft, Astrid, Holder, Geoffrey, Han, Kevin Tianxiang, Choudhury, Somesh, Darstein, Christelle, Paul, Michaela, Drutinus, Eric, Gericke, Germo, Schmid, Herbert A., Pedroncelli, Alberto M.

“…Purpose To assess the pharmacokinetics, pharmacodynamics and tolerability of different doses of octreotide and pasireotide (subcutaneous [sc] and long-acting…”
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First human trial of FTY720, a novel immunomodulator, in stable renal transplant patients by BUDDE, Klemens, SCHMOUDER, Robert L, BRUNKHORST, Reinhard, NASHAN, Bjorn, LÜCKER, Peter W, MAYER, Thomas, CHOUDHURY, Somesh, SKERJANEC, Andrej, KRAUS, Gerolf, NEUMAYER, Hans H

“…FTY720 is a novel immunomodulator to be developed for use in organ transplantation. The primary objective of this study was to measure safety, single-dose…”
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Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose-Escalation and Dose-Expansion Study by Nogova, Lucia, Sequist, Lecia V, Perez Garcia, Jose Manuel, Andre, Fabrice, Delord, Jean-Pierre, Hidalgo, Manuel, Schellens, Jan H M, Cassier, Philippe A, Camidge, D Ross, Schuler, Martin, Vaishampayan, Ulka, Burris, Howard, Tian, G Gary, Campone, Mario, Wainberg, Zev A, Lim, Wan-Teck, LoRusso, Patricia, Shapiro, Geoffrey I, Parker, Katie, Chen, Xueying, Choudhury, Somesh, Ringeisen, Francois, Graus-Porta, Diana, Porter, Dale, Isaacs, Randi, Buettner, Reinhard, Wolf, Jürgen

“…Purpose This two-part, first-in-human study was initiated in patients with advanced solid tumors harboring genetic alterations in fibroblast growth factor…”
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Abstract CT171: Phase I study of BLZ945 alone and with spartalizumab (PDR001) in patients (pts) with advanced solid tumors by Lin, Chia-Chi, Gil-Martin, Marta, Bauer, Todd M., Naing, Aung, Lim, Darren Wan-Teck, Sarantopoulos, John, Geva, Ravit, Ando, Yuichi, Fan, Liqiong, Choudhury, Somesh, Tu, Pei-Jung, Quadt, Cornelia, Santoro, Armando

“…Background: CSF-1R signaling regulates the function of tumor-associated macrophages (TAMs) which are poor prognostic indicators in several cancers. In animal…”
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Comparative Bioavailability of a Single Dose of Trametinib (TMT212) Containing 9% vs 11% Dimethyl Sulfoxide in Randomized Healthy Volunteers to Assess Long‐Term Storage at Room Temperature by Tan, Eugene Y., Chiparus, Ovidiu, Choudhury, Somesh, Kim, Christina, Lau, Mike, Ziltener, Christoph, Ilankumaran, Palanichamy

“…Storage of trametinib tablets outside of 2‐8°C protected from moisture may lead to loss of dimethyl sulfoxide (DMSO) and adversely impact trametinib…”
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Distribution of Lenalidomide Into Semen of Healthy Men After Multiple Oral Doses by Chen, Nianhang, Lau, Henry, Choudhury, Somesh, Wang, Xiaomin, Assaf, Mahmoud, Laskin, Oscar L.

“…Lenalidomide is a thalidomide analog and an immunomodulatory drug with demonstrated efficacy in various hematological malignancies. The distribution of…”
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Phase I dose-escalation study of the protein kinase C (PKC) inhibitor AEB071 in patients with metastatic uveal melanoma by Piperno-Neumann, Sophie, Kapiteijn, Ellen, Larkin, James M. G., Carvajal, Richard D., Luke, Jason J., Seifert, Heike, Roozen, Inge, Zoubir, Mustapha, Yang, Lin, Choudhury, Somesh, Yerramilli-Rao, Padmaja, Hodi, F. Stephen, Schwartz, Gary K.

“…Abstract only…”
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Enteric-coated mycophenolate sodium delivers bioequivalent MPA exposure compared with mycophenolate mofetil by Arns, Wolfgang, Breuer, Stephan, Choudhury, Somesh, Taccard, Guy, Lee, James, Binder, Vera, Roettele, Jürgen, Schmouder, Robert

“…:  Mycophenolic acid (MPA), the active moiety of mycophenolate mofetil (MMF), is routinely used as an adjunct immunosuppressant therapy in renal…”
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A multiphase model of the dynamics of HBV infection in HBeAg-negative patients during pegylated interferon-α2a, lamivudine and combination therapy by COLOMBATTO, Piero, CIVITANO, Luigi, BIZZARRI, Ranieri, OLIVERI, Filippo, CHOUDHURY, Somesh, GIESCHKE, Ronald, BONINO, Ferruccio, BRUNETTO, Maurizia R

“…Using a multiphase bio-mathematical model, we studied the dynamics of hepatitis B virus (HBV) infection in 72 HBeAg-negative patients who received 48 weeks of…”
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Cardioteratogenic dose of ethanol in the chick embryo results in albumin ethanol concentrations comparable to human blood alcohol levels by Bruyere, Jr, H J, Choudhury, S, Nelson, E, Stith, C E

“…Three-day-old chick embryos (Hamburger-Hamilton stages 18-19) were exposed to a dose of ethyl alcohol (0.32 ml of 50% ethanol) that causes cardiac…”
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Pharmacokinetic model for the disposition of 3-methylcholanthrene in channel catfish after slow intraaortic infusion by SOMESH CHOUDHURY, KARARA, A. H, ACE, L. N

“…An inducer of hepatic microsomal oxygenases, 3-methylcholanthrene (3MC), was infused into channel catfish through the dorsal aorta during 2.2-2.7 h to a final…”
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A multiphase model of the dynamics of HBV infection in HBeAg-negative patients during pegylated interferon-alpha2a, lamivudine and combination therapy by Colombatto, Piero, Civitano, Luigi, Bizzarri, Ranieri, Oliveri, Filippo, Choudhury, Somesh, Gieschke, Ronald, Bonino, Ferruccio, Brunetto, Maurizia R

“…Using a multiphase bio-mathematical model, we studied the dynamics of hepatitis B virus (HBV) infection in 72 HBeAg-negative patients who received 48 weeks of…”
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Single-Dose Pharmacokinetics of Nateglinide in Subjects with Hepatic Cirrhosis by Choudhury, Somesh, Hirschberg, Yulia, Filipek, Ronald, Lasseter, Kenneth, McLeod, James F.

“…This single‐dose, open‐label, parallel‐group study compared the pharmacokinetics and tolerability of 120 mg doses of nateglinide, a physiologic mealtime…”
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Pharmacokinetics of flunisolide administered via metered dose inhaler with and without a spacer device and following oral administration by Dickens, G R, Wermeling, D P, Matheny, C J, John, W, Abramowitz, W, Sista, S M, Foster, T, Choudhury, S

“…After inhalation of a glucocorticoid from a meter dose inhaler (MDI), a certain portion of the delivered dose is deposited in the lungs, and the remainder is…”
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ABSORPTION AND DISPOSITION OF MULTIPLE DOSE FTY720 IN HUMANS: Abstract# 183 Poster Board #-Session: P30-I by Choudhury, Somesh, Kahan, Barry D., Leichtman, Allen B., Ferguson, Ronald M., Karlix, Janet L., Schmouder, Robert L., Chodoff, Lawrence, Sablinski, Tomasz

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Differences in bioavailability between oral cyclosporine formulations in maintenance renal transplant patients by Curtis, John J., Barbeito, Ralph, Pirsch, John, Lewis, Richard M., Van Buren, David H., Choudhury, Somesh

“…Previous studies of healthy volunteers and small numbers of transplant recipients have suggested that the oral solution formulation of Sandimmune (cyclosporine…”
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High-performance liquid chromatographic method for the determination of 3-methylcholanthrene in channel catfish plasma by Choudhury, S, Karara, A H, Ace, L N, McFarland, V A

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