Search Results - "CHOKSHI, Shilpa"

Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment by McQuitty, Claire E, Williams, Roger, Chokshi, Shilpa, Urbani, Luca

“…Chronic liver disease when accompanied by underlying fibrosis, is characterized by an accumulation of extracellular matrix (ECM) proteins and chronic…”
Get full text

Novel therapeutic strategies for chronic hepatitis B by Phillips, Sandra, Jagatia, Ravi, Chokshi, Shilpa

“…The last few years have seen a resurgence of activity in the hepatitis B drug pipeline, with many compounds in various stages of development. This review aims…”
Get full text

PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation by Iansante, Valeria, Choy, Pui Man, Fung, Sze Wai, Liu, Ying, Chai, Jian-Guo, Dyson, Julian, Del Rio, Alberto, D’Santos, Clive, Williams, Roger, Chokshi, Shilpa, Anders, Robert A, Bubici, Concetta, Papa, Salvatore

“…Most tumour cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and evade apoptosis. Intriguingly, the molecular mechanisms that link…”
Get full text

Epigenetic upregulation of TET2 is an independent poor prognostic factor for intrahepatic cholangiocarcinoma by Yamashita, Hironori, Tourna, Aikaterini, Akita, Masayuki, Itoh, Tomoo, Chokshi, Shilpa, Ajiki, Tetsuo, Fukumoto, Takumi, Youngson, Neil A., Zen, Yoh

“…Mutations in IDH1/2 and the epigenetic silencing of TET2 occur in leukaemia or glioma in a mutually exclusive manner. Although intrahepatic cholangiocarcinoma…”
Get full text

Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease by Rastovic, Una, Bozzano, Sergio Francesco, Riva, Antonio, Simoni-Nieves, Arturo, Harris, Nicola, Miquel, Rosa, Lackner, Carolin, Zen, Yoh, Zamalloa, Ane, Menon, Krishna, Heaton, Nigel, Chokshi, Shilpa, Palma, Elena

“…Alcohol-related liver disease (ALD) encompasses a range of pathological conditions that are complex to study at the clinical and preclinical levels. Despite…”
Get full text

High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy of Paired Clinical Liver Tissue Samples from Hepatocellular Cancer and Surrounding Region by Fernandes, Wendy M, Harris, Nicola, Zamalloa, Ane, Adofina, Lissette, Srinivasan, Parthi, Menon, Krishna, Heaton, Nigel, Miquel, Rosa, Zen, Yoh, Kelly, Geoff, Jarvis, James A, Oregioni, Alain, Chokshi, Shilpa, Riva, Antonio, Cox, I Jane

“…The global burden of liver cancer is increasing. Timely diagnosis is important for optimising the limited available treatment options. Understanding the…”
Get full text

Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e‐antigen seroconversion by Evans, Alexander, Riva, Antonio, Cooksley, Helen, Phillips, Sandra, Puranik, Smrithi, Nathwani, Amit, Brett, Sara, Chokshi, Shilpa, Naoumov, Nikolai V.

“…Hyperexpression of the programmed death 1 (PD‐1) molecule is a hallmark of exhausted T‐cells, having a negative impact on T‐cell activation and function. We…”
Get full text

A permeability assay for mouse intestinal organoids by den Daas, Stijn Aaron, Soffientini, Ugo, Chokshi, Shilpa, Mehta, Gautam

“…Here, we describe an assay for intestinal permeability in mouse intestinal organoids, although this may also be adapted for other species. Propidium iodide…”
Get full text

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease by Assante, Gabriella, Chandrasekaran, Sriram, Ng, Stanley, Tourna, Aikaterini, Chung, Carolina H, Isse, Kowsar A, Banks, Jasmine L, Soffientini, Ugo, Filippi, Celine, Dhawan, Anil, Liu, Mo, Rozen, Steven G, Hoare, Matthew, Campbell, Peter, Ballard, J William O, Turner, Nigel, Morris, Margaret J, Chokshi, Shilpa, Youngson, Neil A

“…The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous…”
Get full text

Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-bacterial Immunity by Riva, Antonio, Palma, Elena, Devshi, Dhruti, Corrigall, Douglas, Adams, Huyen, Heaton, Nigel, Menon, Krishna, Preziosi, Melissa, Zamalloa, Ane, Miquel, Rosa, Ryan, Jennifer M, Wright, Gavin, Fairclough, Sarah, Evans, Alexander, Shawcross, Debbie, Schierwagen, Robert, Klein, Sabine, Uschner, Frank E, Praktiknjo, Michael, Katzarov, Krum, Hadzhiolova, Tanya, Pavlova, Slava, Simonova, Marieta, Trebicka, Jonel, Williams, Roger, Chokshi, Shilpa

“…Immunoregulatory checkpoint receptors (CR) contribute to the profound immunoparesis observed in alcohol-related liver disease (ALD) and neutralization of…”
Get full text

Peg-Interferon Lambda Treatment Induces Robust Innate and Adaptive Immunity in Chronic Hepatitis B Patients by Phillips, Sandra, Mistry, Sameer, Riva, Antonio, Cooksley, Helen, Hadzhiolova-Lebeau, Tanya, Plavova, Slava, Katzarov, Krum, Simonova, Marieta, Zeuzem, Stephan, Woffendin, Clive, Chen, Pei-Jer, Peng, Cheng-Yuan, Chang, Ting-Tsung, Lueth, Stefan, De Knegt, Robert, Choi, Moon-Seok, Wedemeyer, Heiner, Dao, Michael, Kim, Chang-Wook, Chu, Heng-Chen, Wind-Rotolo, Megan, Williams, Roger, Cooney, Elizabeth, Chokshi, Shilpa

“…IFN-lambda (IFNλ) is a member of the type III IFN family and is reported to possess anti-pathogen, anti-cancer, and immunomodulatory properties; however, there…”
Get full text

Human Immunocompetent Model of Neuroendocrine Liver Metastases Recapitulates Patient-Specific Tumour Microenvironment by Doornebal, Ewald Jan, Harris, Nicola, Riva, Antonio, Jagatia, Ravi, Pizanias, Michail, Prachalias, Andreas, Menon, Krishna, Preziosi, Melissa, Zamalloa, Ane, Miquel, Rosa, Zen, Yoh, Orford, Michael Robert, Eaton, Simon, Heaton, Nigel, Ramage, John, Palma, Elena, Srirajaskanthan, Rajaventhan, Chokshi, Shilpa

“…Neuroendocrine liver metastases (LM-NEN) develop in a considerable proportion of patients with gastroenteropancreatic neuroendocrine neoplasms. There is a…”
Get full text

Correction: Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease by Assante, Gabriella, Chandrasekaran, Sriram, Ng, Stanley, Tourna, Aikaterini, Chung, Carolina H, Isse, Kowsar A, Banks, Jasmine L, Soffientini, Ugo, Filippi, Celine, Dhawan, Anil, Liu, Mo, Rozen, Steven G, Hoare, Matthew, Campbell, Peter, Ballard, J William O, Turner, Nigel, Morris, Margaret J, Chokshi, Shilpa, Youngson, Neil A

Get full text

A Pathogenic Role of Non-Parenchymal Liver Cells in Alcohol-Associated Liver Disease of Infectious and Non-Infectious Origin by Kharbanda, Kusum K, Chokshi, Shilpa, Tikhanovich, Irina, Weinman, Steven A, New-Aaron, Moses, Ganesan, Murali, Osna, Natalia A

“…Now, much is known regarding the impact of chronic and heavy alcohol consumption on the disruption of physiological liver functions and the induction of…”
Get full text

An alcohol-related liver disease multi-stakeholder hub (ARMS-Hub) to enhance research activity in underserved communities in the UK by Dhanda, Ashwin, Allgar, Victoria, Bhala, Neeraj, Callaghan, Lynne, Castro, Joana, Chokshi, Shilpa, Clements, Amanda, Clyne, Wendy, Drummond, Colin, Forrest, Ewan, Manning, Lesley, Parker, Richard, Shawcross, Debbie, Towey, Jennifer

“…Background Alcohol use is the third leading risk factor of death and disability in the UK and costs the NHS £3.5 billion per year. Despite the high prevalence…”
Get full text

Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis by Coombes, Jason D., Choi, Steve S., Swiderska-Syn, Marzena, Manka, Paul, Reid, Danielle T., Palma, Elena, Briones-Orta, Marco A., Xie, Guanhua, Younis, Rasha, Kitamura, Naoto, della Peruta, Marco, Bitencourt, Shanna, Dollé, Laurent, Oo, Ye Htun, Mi, Zhiyong, Kuo, Paul C., Williams, Roger, Chokshi, Shilpa, Canbay, Ali, Claridge, Lee C., Eksteen, Bertus, Diehl, Anna Mae, Syn, Wing-Kin

“…Liver fibrosis develops when hepatic stellate cells (HSC) are activated into collagen-producing myofibroblasts. In non-alcoholic steatohepatitis (NASH), the…”
Get full text

Faecal cytokine profiling as a marker of intestinal inflammation in acutely decompensated cirrhosis by Riva, Antonio, Gray, Elizabeth H., Azarian, Sarah, Zamalloa, Ane, McPhail, Mark J.W., Vincent, Royce P., Williams, Roger, Chokshi, Shilpa, Patel, Vishal C., Edwards, Lindsey A.

“…Gut dysbiosis and inflammation perpetuate loss of gut barrier integrity (GBI) and pathological bacterial translocation (BT) in cirrhosis, contributing to…”
Get full text

Neutrophil Toll-Like Receptor 9 Expression and the Systemic Inflammatory Response in Acetaminophen-Induced Acute Liver Failure by Manakkat Vijay, Godhev K, Ryan, Jennifer M, Abeles, Robin D, Ramage, Stephen, Patel, Vishal, Bernsmeier, Christine, Riva, Antonio, McPhail, Mark J W, Tranah, Thomas H, Markwick, Lee J L, Taylor, Nicholas J, Bernal, William, Auzinger, Georg, Willars, Chris, Chokshi, Shilpa, Wendon, Julia A, Ma, Yun, Shawcross, Debbie L

“…OBJECTIVES:There is a marked propensity for patients with acetaminophen-induced acute liver failure to develop sepsis, which may culminate in multiple organ…”
Get full text

A Perfusion Bioreactor for Longitudinal Monitoring of Bioengineered Liver Constructs by Sassi, Lisa, Ajayi, Omolola, Campinoti, Sara, Natarajan, Dipa, McQuitty, Claire, Siena, Riccardo Rayan, Mantero, Sara, De Coppi, Paolo, Pellegata, Alessandro F, Chokshi, Shilpa, Urbani, Luca

“…In the field of in vitro liver disease models, decellularised organ scaffolds maintain the original biomechanical and biological properties of the…”
Get full text

Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression by Osna, Natalia A, Tikhanovich, Irina, Ortega-Ribera, Martí, Mueller, Sebastian, Zheng, Chaowen, Mueller, Johannes, Li, Siyuan, Sakane, Sadatsugu, Weber, Raquel Carvalho Gontijo, Kim, Hyun Young, Lee, Wonseok, Ganguly, Souradipta, Kimura, Yusuke, Liu, Xiao, Dhar, Debanjan, Diggle, Karin, Brenner, David A, Kisseleva, Tatiana, Attal, Neha, McKillop, Iain H, Chokshi, Shilpa, Mahato, Ram, Rasineni, Karuna, Szabo, Gyongyi, Kharbanda, Kusum K

“…Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with…”
Get full text