Search Results - "CHO, KEVIN"
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Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State
Published in Cell chemical biology (21-03-2019)“…The initiation and execution of cell death can be regulated by various lipids. How the levels of environmental (exogenous) lipids impact cell death sensitivity…”
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An accelerated workflow for untargeted metabolomics using the METLIN database
Published in Nature biotechnology (01-09-2012)“…Metabolites, which are typically recognized as small molecules that are involved in cellular reactions, provide a functional signature of phenotype that is…”
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3
Using mass spectrometry imaging to map fluxes quantitatively in the tumor ecosystem
Published in Nature communications (19-05-2023)“…Tumors are comprised of a multitude of cell types spanning different microenvironments. Mass spectrometry imaging (MSI) has the potential to identify metabolic…”
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4
Metabolism Links Bacterial Biofilms and Colon Carcinogenesis
Published in Cell metabolism (02-06-2015)“…Bacterial biofilms in the colon alter the host tissue microenvironment. A role for biofilms in colon cancer metabolism has been suggested but to date has not…”
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5
BAP1 promotes osteoclast function by metabolic reprogramming
Published in Nature communications (22-09-2023)“…Treatment of osteoporosis commonly diminishes osteoclast number which suppresses bone formation thus compromising fracture prevention. Bone formation is not…”
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Race Is Associated With Risk of Salvage Procedures and Postoperative Complications After Hip Procedures in Children With Cerebral Palsy
Published in Journal of pediatric orthopaedics (01-10-2022)“…Background: Despite the many surgical interventions available for spastic hip dysplasia in children with cerebral palsy, a radical salvage hip procedure may…”
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Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock
Published in Cell reports (Cambridge) (22-10-2024)“…Organisms integrate circadian and metabolic signals to optimize substrate selection to survive starvation, yet precisely how this occurs is unclear. Here, we…”
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Mapping thalamocortical functional connectivity with large-scale brain networks in patients with first-episode psychosis
Published in Scientific reports (06-10-2021)“…Abnormal thalamocortical networks involving specific thalamic nuclei have been implicated in schizophrenia pathophysiology. While comparable topography of…”
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MYC sensitises cells to apoptosis by driving energetic demand
Published in Nature communications (09-08-2022)“…The MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. MYC induces…”
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A High-Valent Iron–Oxo Corrolazine Activates C–H Bonds via Hydrogen-Atom Transfer
Published in Journal of the American Chemical Society (02-05-2012)“…Oxidation of the FeIII complex (TBP8Cz)FeIII [TBP8Cz = octakis(4-tert-butylphenyl)corrolazinate] with O-atom transfer oxidants under a variety of conditions…”
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A View from Above: Cloud Plots to Visualize Global Metabolomic Data
Published in Analytical chemistry (Washington) (15-01-2013)“…Global metabolomics describes the comprehensive analysis of small molecules in a biological system without bias. With mass spectrometry-based methods, global…”
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Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug-resistant Mycobacterium tuberculosis
Published in mBio (13-03-2024)“…Of the approximately 10 million cases of ( ) infections each year, over 10% are resistant to the frontline antibiotic isoniazid (INH). INH resistance is…”
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Aberrant temporal behavior of mismatch negativity generators in schizophrenia patients and subjects at clinical high risk for psychosis
Published in Clinical neurophysiology (01-02-2017)“…Highlights • Schizophrenic patients and clinical high risk subjects show decreased mismatch negativity (MMN) strength in frontal and temporal cortices. •…”
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Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness
Published in eLife (18-07-2019)“…Metabolic cycles are a fundamental element of cellular and organismal function. Among the most critical in higher organisms is the Cori Cycle, the systemic…”
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After the feature presentation: technologies bridging untargeted metabolomics and biology
Published in Current opinion in biotechnology (01-08-2014)“…Graphical abstract…”
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Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism
Published in Molecular metabolism (Germany) (01-04-2023)“…The mitochondrial pyruvate carrier (MPC) has emerged as a therapeutic target for treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis…”
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Regulation of obesity and insulin resistance by hypoxia-inducible factors
Published in Hypoxia (01-01-2014)“…In obesity, dysregulated metabolism and aberrant expansion of adipose tissue lead to the development of tissue hypoxia that plays an important role in…”
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Journal Article Book Review -
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The Bacteriophage pEp_SNUABM_08 Is a Novel Singleton Siphovirus with High Host Specificity for Erwinia pyrifoliae
Published in Viruses (25-06-2021)“…Species belonging to the genus Erwinia are predominantly plant pathogens. A number of bacteriophages capable of infecting Erwinia have been used for the…”
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Investigation of the structure of detonation waves in a non-premixed hydrogen–air rotating detonation engine using mid-infrared imaging
Published in Proceedings of the Combustion Institute (2019)“…The structure of detonation waves propagating through the annular channel of an optically accessible non-premixed rotating detonation engine (RDE) are…”
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An experimental study of the effects of catalysts on an ammonium perchlorate based composite propellant using 5 kHz PLIF
Published in Combustion and flame (01-04-2012)“…The catalytic effect of iron (III) oxide (Fe2O3) and copper (II) oxide (CuO) on an ammonium perchlorate (AP) and hydroxyl-terminated polybutadiene (HTPB)…”
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