Transfer of carbapenem-resistant plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in patient

Klebsiella pneumoniae carbapenemase (KPC) 3-producing Escherichia coli was isolated from a carrier of KPC-3-producing K. pneumoniae. The KPC-3 plasmid was identical in isolates of both species. The patient's gut flora contained a carbapenem-susceptible E. coli strain isogenic with the KPC-3-pro...

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Bibliographic Details
Published in:	Emerging infectious diseases Vol. 16; no. 6; pp. 1014 - 1017
Main Authors:	GOREN, M.G, CARMELI, Y, SCHWABER, M.J, CHMELNISTSKY, I, SCHECHNER, V, NAVON-VENEZIA, S
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01-06-2010 Centers for Disease Control and Prevention
Subjects:	Aged, 80 and over Anti-Bacterial Agents - administration & dosage bacteria Bacterial pneumonia Bacterial Proteins - biosynthesis Bacterial Proteins - genetics beta-Lactamases - biosynthesis beta-Lactamases - genetics beta-Lactams - administration & dosage Biological and medical sciences carbapenem-resistant plasmid Colistin - administration & dosage Conjugation, Genetic Disease transmission Dispatch Drug resistance Drug Resistance, Bacterial - genetics Drug Therapy, Combination Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Infections - complications Escherichia coli Infections - metabolism Escherichia coli Infections - microbiology Gastrointestinal Tract - microbiology Health aspects Horizontal gene transfer Humans Israel Klebsiella Infections - complications Klebsiella Infections - drug therapy Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics KPC Male Medical sciences Metronidazole - administration & dosage Miscellaneous plasmids Plasmids - genetics Plasmids - metabolism Pneumonia Public health. Hygiene Public health. Hygiene-occupational medicine Vancomycin - administration & dosage Israel Drug Nosocomial infection Antibiotic Sensitivity resistance Hemodialysis Escherichia coli Bacteria Hospital Hygiene Enterobacteriaceae
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Summary:	Klebsiella pneumoniae carbapenemase (KPC) 3-producing Escherichia coli was isolated from a carrier of KPC-3-producing K. pneumoniae. The KPC-3 plasmid was identical in isolates of both species. The patient's gut flora contained a carbapenem-susceptible E. coli strain isogenic with the KPC-3-producing isolate, which suggests horizontal interspecies plasmid transfer.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1606.091671