Search Results - "CHIU, Anna"
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Impact of Infectious Disease Consultation on Quality of Care, Mortality, and Length of Stay in Staphylococcus aureus Bacteremia: Results From a Large Multicenter Cohort Study
Published in Clinical infectious diseases (15-05-2015)“…Background. We assessed the impact of infectious disease (ID) consultation on management and outcome in patients with Staphylococcus aureus bacteremia (SAB)…”
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A Case of Remote Asymmetric Induction in the Peptide-Catalyzed Desymmetrization of a Bis(phenol)
Published in Journal of the American Chemical Society (03-12-2008)“…We report a catalytic approach to the synthesis of a key intermediate on the synthetic route to a pharmaceutical drug candidate in single enantiomer form. In…”
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Asymmetric Syntheses of Pectenotoxins-4 and -8, Part II: Synthesis of the C20-C30 and C31-C40 Subunits and Fragment Assembly
Published in Angewandte Chemie International Edition (02-12-2002)“…The total syntheses of the marine macrolides pectenotoxins‐4 and ‐8 have been realized. The pectenotoxins are a new class of marine macrolides that exhibit a…”
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Usefulness of previous methicillin-resistant Staphylococcus aureus screening results in guiding empirical therapy for S aureus bacteremia
Published in The Canadian journal of infectious diseases & medical microbiology (01-07-2015)“…Staphylococcus aureus bacteremia (SAB) is an important infection. Methicillin-resistant S aureus (MRSA) screening is performed on hospitalized patients for…”
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Use of Transthoracic Echocardiography in the Management of Low-Risk Staphylococcus aureus Bacteremia
Published in JACC. Cardiovascular imaging (01-08-2015)“…Abstract Objectives The aim of this study was to develop a prediction model to identify patients with low-risk Staphylococcus aureus bacteremia (SAB), in whom…”
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Clinical targeting of HIV capsid protein with a long-acting small molecule
Published in Nature (London) (27-08-2020)“…Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis 1…”
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Lenacapavir Exhibits Atropisomerism-Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway
Published in The Journal of pharmacology and experimental therapeutics (18-09-2024)“…Lenacapavir (LEN), a long-acting injectable, is the first approved human immunodeficiency virus type 1 capsid inhibitor and one of a few Food and Drug…”
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Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent
Published in Molecular pharmaceutics (04-12-2023)“…Lenacapavir (LEN) is a picomolar first-in-class capsid inhibitor of human immunodeficiency virus type 1 (HIV-1) with a multistage mechanism of action and no…”
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Comparative effectiveness of cefazolin versus cloxacillin as definitive antibiotic therapy for MSSA bacteraemia: results from a large multicentre cohort study
Published in Journal of antimicrobial chemotherapy (01-05-2015)“…We compared the effectiveness of cefazolin versus cloxacillin in the treatment of MSSA bacteraemia in terms of mortality and relapse. A retrospective cohort…”
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Synthesis of Rovafovir Etalafenamide (Part I): Active Pharmaceutical Ingredient Process Development, Scale-Up, and Impurity Control Strategy
Published in Organic process research & development (21-05-2021)“…This manuscript describes the chemical process development and multi-kilogram synthesis of rovafovir etalafenamide (GS-9131), a phosphonamidate prodrug…”
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Use of Transthoracic Echocardiography in the Management of Low-Risk Staphylococcus aureus Bacteremia: Results From a Retrospective Multicenter Cohort Study
Published in JACC. Cardiovascular imaging (01-08-2015)“…The aim of this study was to develop a prediction model to identify patients with low-risk Staphylococcus aureus bacteremia (SAB), in whom infective…”
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Remote Desymmetrization at Near-Nanometer Group Separation Catalyzed by a Miniaturized Enzyme Mimic
Published in Journal of the American Chemical Society (27-12-2006)“…The chirality of biological receptors often requires syntheses of therapeutic compounds in single enantiomer form. The field of asymmetric catalysis addresses…”
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Effect of Counterion Structure on Rates and Diastereoselectivities in α,β-Unsaturated Iminium-Ion Diels–Alder Reactions
Published in Organic letters (15-07-2011)“…The use of cyclic α,β-unsaturated iminium-ion dienophiles is documented in two highly diastereoselective Diels–Alder (DA) reactions. The dienophilic counterion…”
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Usefulness of previous methicillin-resistant Staphylococcus aureus screening results in guiding empirical therapy for S aureus bacteremia/L'utilité d'un dépistage antérieur du Staphylococcus aureus résistant à la méthicilline pour orienter le traitement empirique de la bactériémie à S. aureus
Published in The Canadian journal of infectious diseases & medical microbiology (01-07-2015)Get full text
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Detecting Hate Speech on Social Media with Respect to Adolescent Vulnerability
Published in 2023 IEEE 13th Annual Computing and Communication Workshop and Conference (CCWC) (08-03-2023)“…Social media has become one of the biggest plat-forms for children and young adolescents to spend their free time. Due to the rising age gap between people…”
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Conference Proceeding -
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A randomized controlled trial of low-dose recombinant human growth hormone in the treatment of malnourished elderly medical patients
Published in The journal of clinical endocrinology and metabolism (01-05-2001)“…High-dose recombinant human GH (rhGH) has been shown to improve the nutritional status of malnourished older adults. It is uncertain whether low-dose rhGH is…”
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Studies toward the total synthesis of spiro-prorocentrimine
Published 01-01-2005“…The synthesis of the C14--C26 region of spiro-prorocentrimine (1) was completed in 18 linear steps and 9.3% overall yield. Key transformations include a…”
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Dissertation -
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Studies toward the total synthesis of spiro-prorocentrimine
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Dissertation