Search Results - "CHISHOLM, Jeffrey W"

Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells by Hess, Daniel, Chisholm, Jeffrey W, Igal, R Ariel

“…Lung cancer is the most frequent form of cancer. The survival rate for patients with metastatic lung cancer is approximately 5%, hence alternative therapeutic…”
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Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK by Scaglia, Natalia, Chisholm, Jeffrey W, Igal, R Ariel

“…Cancer cells activate the biosynthesis of saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) in order to sustain an increasing demand for…”
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Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells by Nashed, Mary, Chisholm, Jeffrey W, Igal, R Ariel

“…Stearoyl-CoA desaturase-1 (SCD1), the main enzyme that converts saturated fatty acids into monounsaturated fatty acids, is a key factor in the mechanisms of…”
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The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse by Chisholm, Jeffrey W., Hong, Jenny, Mills, Scott A., Lawn, Richard M.

“…Liver X receptor (LXR) ligands are currently being evaluated as potential therapeutic agents for the treatment of low HDL. The LXR ligand T0901317 elevates ATP…”
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ApoA-I secretion from HepG2 cells: evidence for the secretion of both lipid-poor apoA-I and intracellularly assembled nascent HDL by Chisholm, Jeffrey W, Burleson, Ellen R, Shelness, Gregory S, Parks, John S

“…The goal of this study was to determine whether apolipoprotein A-I (apoA-I) is lipidated before secretion by HepG2 cells. ApoA-I was extracted from microsomes…”
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HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney by Lee, Ji-Young, Timmins, Jenelle M, Mulya, Anny, Smith, Thomas L, Zhu, Yiwen, Rubin, Edward M, Chisholm, Jeffrey W, Colvin, Perry L, Parks, John S

“…Patients homozygous for Tangier disease have a near absence of plasma HDL as a result of mutations in ABCA1 and hypercatabolize normal HDL particles. To…”
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Effect of Ranolazine on A1C and Glucose Levels in Hyperglycemic Patients With Non-ST Elevation Acute Coronary Syndrome by Chisholm, Jeffrey W, Goldfine, Allison B, Dhalla, Arvinder K, Braunwald, Eugene, Morrow, David A, Karwatowska-Prokopczuk, Ewa, Belardinelli, Luiz

“…OBJECTIVE: We determined the relationships between glycemia at randomization, concurrent antidiabetic therapy, and change in A1C and fasting plasma glucose…”
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Negative Charge at Amino Acid 149 Is the Molecular Determinant for Substrate Specificity of Lecithin:Cholesterol Acyltransferase for Phosphatidylcholine Containing 20-Carbon sn-2 Fatty Acyl Chains by Zhao, Yue, Wang, Jingchuan, Gebre, Abraham K., Chisholm, Jeffrey W., Parks, John S.

“…We previously described a point mutation in human LCAT (E to A at residue 149; hE149A) that demonstrated greater activity with phosphatidylcholine (PC)…”
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A1 adenosine receptor: role in diabetes and obesity by Dhalla, Arvinder K, Chisholm, Jeffrey W, Reaven, Gerald M, Belardinelli, Luiz

“…Adenosine mediates its diverse effects via four subtypes (A(1), A(2A), A(2B) and A(3)) of G-protein-coupled receptors. The A(1) adenosine receptor (A(1)AR)…”
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Adenosine A1 receptors do not play a major role in the regulation of lipogenic gene expression in hepatocytes by Yang, Ming, Chu, Ruth, Chisholm, Jeffrey W., Doege, Holger, Belardinelli, Luiz, Dhalla, Arvinder K.

“…Activation of adenosine A1 receptors was reported to promote fatty acid synthesis in AML-12 cells, by increasing the expression of SREBP-1c (sterol regulatory…”
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Sulfonylureas uncouple glucose-dependence for GPR40-mediated enhancement of insulin secretion from INS-1E cells by Yang, Ming, Chisholm, Jeffrey W., Soelaiman, Sandriyana, Shryock, John C.

“…Activation of GPR40 is reported to enhance insulin secretion in the presence of glucose. We determined whether sulfonylureas could replace glucose for…”
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Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O, Parkhill, Eric Q, Vasilevich, Natalya I, Glushkov, Andrei I, Zilbershtein, Timur M, Ivanov, Alexei V, Cole, Andrew G, Henderson, Ian, Zautke, Nathan A, Brunn, Sandra A, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W, Zablocki, Jeff

“…We identified a series of structurally novel SCD (Delta9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the…”
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Characterization of C-terminal histidine-tagged human recombinant lecithin:cholesterol acyltransferase by Chisholm, J W, Gebre, A K, Parks, J S

“…Lecithin:cholesterol acyltransferase (LCAT) is the plasma enzyme that catalyzes esterification of the sn-2 fatty acid of phospholipid to cholesterol. To…”
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Liver X receptors alpha and beta regulate renin expression in vivo by Morello, Fulvio, de Boer, Rudolf A, Steffensen, Knut R, Gnecchi, Massimiliano, Chisholm, Jeffrey W, Boomsma, Frans, Anderson, Leonard M, Lawn, Richard M, Gustafsson, Jan-Ake, Lopez-Ilasaca, Marco, Pratt, Richard E, Dzau, Victor J

“…The renin-angiotensin-aldosterone system controls blood pressure and salt-volume homeostasis. Renin, which is the first enzymatic step of the cascade, is…”
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Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Zilbershtein, Timur M., Migulin, Vasily A., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., McGregor, Malcolm J., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…Two structurally distinct series of SCD (Δ9 desaturase) inhibitors (1 and 2) have been previously reported by our group. In the present work, we merged the…”
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Lipid-sensing high-throughput ApoA-I assays by Niedziela-Majka, Anita, Lad, Latesh, Chisholm, Jeffrey W, Lagpacan, Leanna, Schwartz, Karen, Hung, Magdeleine, Jin, Debi, Fung, Wanchi, Brendza, Katherine M, Liu, Xiaohong, Pagratis, Nikos, Sakowicz, Roman

“…Apolipoprotein A-I (ApoA-I), a primary protein component of high-density lipoprotein (HDL), plays an important role in cholesterol metabolism mediating the…”
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Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., Zilbershtein, Timur M., Mayboroda, Elena I., Boze, Melanie A., Cole, Andrew G., Henderson, Ian, Zautke, Nathan A., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…We discovered a structurally novel SCD inhibitor CVT-11,563 (IC50 119nM, HEPG2 assay), selective against Δ5 and Δ6 desaturases, with excellent PK parameters…”
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Human apoA-I expression in CETP transgenic rats leads to lower levels of apoC-I in HDL and to magnification of CETP-mediated lipoprotein changes by Masson, David, Pais de Barros, Jean-Paul, Zak, Zoulika, Gautier, Thomas, Le Guern, Naig, Assem, Mahfoud, Chisholm, Jeffrey W, Paterniti, Jr, James R, Lagrost, Laurent

“…Plasma cholesteryl ester transfer protein (CETP) has a profound effect on neutral lipid transfers between HDLs and apolipoprotein B (apoB)-containing…”
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Accumulation of cholestatic lipoproteins in ANIT-treated human apolipoprotein A-I transgenic rats is diminished through dose-dependent apolipoprotein A-I activation of LCAT by Chisholm, Jeffrey W, Paterniti, James R, Dolphin, Peter J

“…Administration of α-naphthylisothiocyanate (ANIT) to rats induces changes to plasma lipids consistent with cholestasis. We have previously shown (J. Lipid Res…”
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Effect of Ranolazine on A1C and Glucose Levels in Hyperglyemic Patients With Non-ST Elevation Acute Coronary Syndrome by CHISHOLM, Jeffrey W, GOLDFINE, Allison B, DHALLA, Arvinder K, BRAUNWALD, Eugene, MORROW, David A, KARWATOWSKA-PROKOPCZUK, Ewa, BELARDINELLI, Luiz

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