Search Results - "CHIRKOV, Yuliy Y"

Impairment of Anti-Aggregatory Responses to Nitric Oxide and Prostacyclin: Mechanisms and Clinical Implications in Cardiovascular Disease by Chirkov, Yuliy Y, Nguyen, Thanh H, Horowitz, John D

“…The propensity towards platelet-rich thrombus formation increases substantially during normal ageing, and this trend is mediated by decreases in platelet…”
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Effects of Soluble Guanylate Cyclase Stimulators and Activators on Anti-Aggregatory Signalling in Patients with Coronary Artery Spasm by Muminovic, Armin, Chirkov, Yuliy Y, Horowitz, John D

“…Impairment of the nitric oxide/soluble guanylate cyclase (NO)/sGC) signalling cascade is associated with many forms of cardiovascular disease, resulting not…”
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Coronary "Microvascular Dysfunction": Evolving Understanding of Pathophysiology, Clinical Implications, and Potential Therapeutics by Kei, Chun Yeung, Singh, Kuljit, Dautov, Rustem F, Nguyen, Thanh H, Chirkov, Yuliy Y, Horowitz, John D

“…Until recently, it has been generally held that stable angina pectoris (SAP) primarily reflects the presence of epicardial coronary artery stenoses due to…”
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N-Terminal Pro-Brain Natriuretic Protein Levels in Takotsubo Cardiomyopathy by Nguyen, Thanh Ha, MD, MMedSci, Neil, Christopher J., MBBS, Sverdlov, Aaron L., MBBS, Mahadavan, Gnanadevan, BMBS, Chirkov, Yuliy Y., PhD, Kucia, Angela M., PhD, Stansborough, Jeanette, RN, Beltrame, John F., BSc, BMBS, PhD, Selvanayagam, Joseph B., MBBS (Hons), DPhil, Zeitz, Christopher J., MBBS, PhD, OstJ, Struthers, Allan D., BSc (Hons), MBChB, DCH, Frenneaux, Michael P., MBBS, MD, Horowitz, John D., MBBS, BMedSci(Hons), PhD

“…Takotsubo cardiomyopathy (TTC) is characterized by reversible left ventricular (LV) systolic dysfunction independent of fixed coronary disease or coronary…”
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Neutrophil-Initiated Myocardial Inflammation and Its Modulation by B-Type Natriuretic Peptide: A Potential Therapeutic Target by Liu, Saifei, Chirkov, Yuliy Y, Horowitz, John D

“…Activation of neutrophils is a critically important component of the innate immune response to bacterial and chemical stimuli, and culminates in the…”
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TakoTsubo Syndrome: First an Acute Coronary Vasculitis and Then Prolonged Myocarditis? by Girolamo, Olivia C, Surikow, Sven Y, Ong, Gao-Jing, Nguyen, Thanh Ha, Kucia, Angela M, Chirkov, Yuliy Y, Horowitz, John D

“…Since its initial description by Japanese investigators 30 years ago, TakoTsubo Syndrome (TTS) has variously been regarded as a form of acute coronary syndrome…”
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Thioredoxin-Interacting Protein: Pathophysiology and Emerging Pharmacotherapeutics in Cardiovascular Disease and Diabetes by Chong, Cher-Rin, Chan, Wai Ping A., Nguyen, Thanh H., Liu, Saifei, Procter, Nathan E. K., Ngo, Doan T., Sverdlov, Aaron L., Chirkov, Yuliy Y., Horowitz, John D.

“…The thioredoxin system, which consists of thioredoxin (Trx), nicotinamide adenine dinucleotide phosphate (NADPH) and thioredoxin reductase (TrxR), has emerged…”
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Endothelial dysfunction and glycocalyx shedding in heart failure: insights from patients receiving cardiac resynchronisation therapy by Ajaero, Chukwudiebube N., Procter, Nathan E. K., Chirkov, Yuliy Y., Heresztyn, Tamila, Arstall, Margaret A., McGavigan, Andrew D., Frenneaux, Michael P., Horowitz, John D.

“…To determine (a) whether chronic heart failure with reduced ejection fraction (HFrEF) is associated with increased glycocalyx shedding; (b) whether glycocalyx…”
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Perhexiline Therapy in Patients with Type 2 Diabetes: Incremental Insulin Resistance despite Potentiation of Nitric Oxide Signaling by Chong, Cher-Rin, Liu, Saifei, Imam, Hasan, Heresztyn, Tamila, Sallustio, Benedetta C, Chirkov, Yuliy Y, Horowitz, John D

“…Perhexiline (Px) inhibits carnitine palmitoyltransferase 1 (CPT1), which controls uptake of long chain fatty acids into mitochondria. However, occasional cases…”
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Reversal of Hyperglycemia: Effects on Nitric Oxide Signaling by Chong, Cher-Rin, BPharm, Liu, Saifei, MBBS, MBiotech, Licari, Giovanni, PhD, Heresztyn, Tamila, BSc, Chirkov, Yuliy Y., PhD, Ngo, Doan T., PhD, Horowitz, John D., MBBS, PhD

“…Abstract Background Hyperglycemia in patients with acute coronary syndromes is associated with poor outcomes, and its rapid correction with insulin infusion…”
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Modulation of myocardial metabolism: an emerging therapeutic principle by Horowitz, John D, Chirkov, Yuliy Y, Kennedy, Jennifer A, Sverdlov, Aaron L

“…PURPOSE OF REVIEWWe focus on the molecular and cellular basis of the improvement in myocardial energetics, which might represent an attractive therapeutic…”
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Premature Aging of Cardiovascular/Platelet Function in Polycystic Ovarian Syndrome by Chan, Wai Ping A., MBBS, PhD, Ngo, Doan T., PhD, Sverdlov, Aaron L., MBBS, PhD, Rajendran, Sharmalar, MBBS, PhD, Stafford, Irene, BSc, Heresztyn, Tamila, BSc, Chirkov, Yuliy Y., PhD, Horowitz, John D., MBBS, PhD

“…Abstract Objective The objective of this study was to compare the impact of aging on nitric oxide (NO) modulation of platelet and vascular function in healthy…”
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Determinants of Occurrence of Aortic Sclerosis in an Aging Population by Ngo, Doan T.M., BPharm, PhD, Sverdlov, Aaron L., MBBS, Willoughby, Scott R., PhD, Nightingale, Angus K., MD, Chirkov, Yuliy Y., PhD, McNeil, John J., MBBS, PhD, Horowitz, John D., MBBS, PhD

“…Objectives We sought to identify clinical, physiological, and biochemical correlates, including markers of endothelial dysfunction and of tissue nitric oxide…”
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Gender and tachycardia： independent modulation of platelet reactivity in patients with atrial fibrillation by Procter, Nathan Ek, Ball, Jocasta, Ngo, Doan Tm, Isenberg, Jeffrey S, Hylek, Elaine M, Chirkov, Yuliy Y, Stewart, Simon, Horowitz, John D

“…Background Female patients with atrial fibrillation （AF） experience increased risk of thromboembolism compared to males, an observation that is reflected by…”
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Impairment of platelet NO signalling in coronary artery spasm: role of hydrogen sulphide by Imam, Hasan, Nguyen, Thanh H., Stafford, Irene, Liu, Saifei, Heresztyn, Tamila, Chirkov, Yuliy Y., Horowitz, John D.

“…Background and Purpose The pathophysiology of coronary artery spasm (CAS), with its associated ischaemic crises, is currently poorly understood and treatment…”
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Ramipril Sensitizes Platelets to Nitric Oxide by Willoughby, Scott R., PhD, Rajendran, Sharmalar, MBBS, PhD, Chan, Wai P., MBBS, Procter, Nathan, BSc, Leslie, Sue, RN, Liberts, Elizabeth A., PhD, Heresztyn, Tamila, BSc, Chirkov, Yuliy Y., PhD, Horowitz, John D., MBBS, PhD

“…Objectives Using 2 sequential studies in HOPE (Heart Outcomes Prevention Evaluation) study–type patients, the aims of this study were: 1) to test the…”
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Identifying clopidogrel resistance during chronic therapy: the case for a biochemical approach by Horowitz, John D, Chirkov, Yuliy Y

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Increased Rate of Hospitalization With Prinzmetal Angina: What Exactly Is Happening? by Nguyen, Thanh Ha, Chirkov, Yuliy Y, Liu, Sai Fei, Stafford, Irene, Horowitz, John D.

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Does high on-treatment platelet aggregability reflect poor individual response to clopidogrel? by Nooney, Vivek B., Hurst, Nicola L., De Caterina, Raffaele, Chirkov, Yuliy Y., Horowitz, John D.

“…On-treatment platelet aggregability represents the major form of functional assessment for patients treated with P2Y12 receptor antagonists, with “high”…”
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Impaired tissue responsiveness to organic nitrates and nitric oxide: a new therapeutic frontier? by Chirkov, Yuliy Y, Horowitz, John D

“…Nitric oxide (NO) is a physiologically important modulator of both vasomotor tone and platelet aggregability. These effects of NO are predominantly mediated by…”
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