Search Results - "CHIPMAN, J. K"

A DNA expression array to detect toxic stress response in European flounder ( Platichthys flesus) by Williams, T.D., Gensberg, K., Minchin, S.D., Chipman, J.K.

“…As a first stage in developing a DNA array-based approach to investigating the effects of pollutants on an environmentally relevant European fish species, we…”
Get full text

Evidence of Oxidative Stress and Associated DNA Damage, Increased Proliferative Drive, and Altered Gene Expression in Rat Liver Produced by the Cholangiocarcinogenic Agent Furan by Hickling, K. C., Hitchcock, J. M., Oreffo, V., Mally, A., Hammond, T. G., Evans, J. G., Chipman, J. K.

“…Furan is a potent cholangiocarcinogen in rat by an as yet undefined mechanism. The risk to man remains unclear. Using a time-course stop study design, we have…”
Get full text

Disruption of Gap Junctions in Toxicity and Carcinogenicity by Chipman, J. Kevin, Mally, Angela, Edwards, Gareth O.

“…Although the specific role of connexin-mediated gap junctional intercellular communication in the control of cell homeostasis, proliferation, and death are…”
Get full text

Activity of OGG1 variants in the repair of pro-oxidant-induced 8-oxo-2′-deoxyguanosine by Smart, D.J., Chipman, J.K., Hodges, N.J.

“…Cells are continuously exposed to damaging reactive oxygen species (ROS), which are produced from both endogenous and exogenous sources. 8-Oxodeoxyguanosine…”
Get full text

Hepatic transcriptomic profiles of European flounder ( Platichthys flesus) from field sites and computational approaches to predict site from stress gene responses following exposure to model toxicants by Falciani, F., Diab, A.M., Sabine, V., Williams, T.D., Ortega, F., George, S.G., Chipman, J.K.

“…Genomic technologies offer opportunities to gain a more global assessment of the health status of an organism through an understanding of the functional…”
Get full text

Induction and Progression of Cholangiofibrosis in Rat Liver Injured by Oral Administration of Furan by Hickling, K. C., Hitchcock, J. M., Chipman, J. K., Hammond, T. G., Evans, J. G.

“…Cholangiofibrosis is a structural anomaly that precedes the development of cholangiocarcinoma in some rodent models. In this article, the authors examine the…”
Get full text

Macromolecule oxidation and DNA repair in mussel ( Mytilus edulis L.) gill following exposure to Cd and Cr(VI) by Emmanouil, C., Sheehan, T.M.T., Chipman, J.K.

“…The oxidation of DNA and lipid was analysed in the marine mussel ( Mytilus edulis) in response to exposure (10 μg/l and 200 μg/l) to cadmium (Cd) and chromium…”
Get full text

Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells by Hodges, N.J., Chipman, J.K.

“…Hexavalent chromium is a genotoxic human pulmonary carcinogen that elevates DNA oxidation, apparently through the generation of reactive DNA-damaging…”
Get full text

A cDNA microarray for the three-spined stickleback, Gasterosteus aculeatus L., and analysis of the interactive effects of oestradiol and dibenzanthracene exposures by Geoghegan, F., Katsiadaki, I., Williams, T. D., Chipman, J. K.

“…The stickleback is a useful model species for aquatic toxicology and endocrinology and with the recent sequencing of its genome, ecotoxicogenomics. The effects…”
Get full text

Seasonal variation in cytochrome P450 immunopositive protein levels, lipid peroxidation and genetic toxicity in digestive gland of the mussel Mytilus edulis by Shaw, J.P., Large, A.T., Donkin, P., Evans, S.V., Staff, F.J., Livingstone, D.R., Chipman, J.K., Peters, L.D.

“…The relationship between cytochrome P450 1A- and 2E-immunopositive proteins, lipid peroxidation and DNA strand breaks (SBs) was studied in Mytilus edulis…”
Get full text

Different mechanisms of modulation of gap junction communication by non-genotoxic carcinogens in rat liver in vivo by Cowles, C, Mally, A, Chipman, J.K

“…Abstract This is a comparative study of the mechanisms by which three different rodent non-genotoxic carcinogens modulate connexin-mediated gap junction…”
Get full text

Silver and nanoparticles of silver in wound dressings: a review of efficacy and safety by Wilkinson, L.J., White, R.J., Chipman, J.K.

“…Wound infections present a significant clinical challenge, impacting on patient morbidity and mortality, with significant economic implications…”
Get full text

Gap junction communication dynamics and bystander effects from ultrasoft X-rays by EDWARDS, G. O, BOTCHWAY, S. W, HIRST, G, WHARTON, C. W, CHIPMAN, J. K, MELDRUM, R. A

“…Gap junctions provide a route for small molecules to pass directly between cells. Toxic species may spread through junctions into 'bystander' cells, which may…”
Get full text

The multiple influences of glutathione on bromate genotoxicity: Implications for the dose–response relationship by Chipman, J.K., Parsons, J.L., Beddowes, E.J.

“…Glutathione displays multiple roles in the oxidative genotoxicity of potassium bromate. On the one hand, reduced glutathione has a demonstrated role in the…”
Get full text

The role of glutathione in DNA damage by potassium bromate in vitro by Parsons, J.L., Chipman, J.K.

“…We have investigated the role of reduced glutathione (GSH) in the genetic toxicity of the rodent renal carcinogen potassium bromate (KBrO3). A statistically…”
Get full text

Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1 by Lautraite, S., Musonda, A.C., Doehmer, J., Edwards, G.O., Chipman, J.K.

“…The effects of the flavonoids quercetin, apigenin and chrysin (10 μM) on the genetic toxicity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and…”
Get full text

Detection of DNA strand breaks in brown trout ( Salmo trutta) hepatocytes and blood cells using the single cell gel electrophoresis (comet) assay by Mitchelmore, C.L, Chipman, J.K

“…The single cell gel electrophoresis or `comet' assay was employed to detect DNA strand breaks (SB) induced in isolated brown trout hepatocytes and blood cells…”
Get full text

Different levels of mussel (Mytilus edulis) DNA strand breaks following chronic field and acute laboratory exposure to polycyclic aromatic hydrocarbons by Large, A.T, Shaw, J.P, Peters, L.D, McIntosh, A.D, Webster, L, Mally, A, Chipman, J.K

“…Levels of polycyclic aromatic hydrocarbons (PAHs) including benzo[a]pyrene (B[a]P) were at least seven-fold higher in mussels sampled from a polluted site…”
Get full text

CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane by Barcelo, Silvia, Gardiner, John M., Gescher, Andreas, Chipman, J.Kevin

“…The broccoli constituent sulforaphane (1-isothiocyanate-4-methylsulfinylbutane) has previously been shown to protect rats against 9, 10-dimethyl-1,…”
Get full text

Induction of DNA-strand breaks in human peripheral blood lymphocytes and A549 lung cells by sodium dichromate: association with 8-oxo-2-deoxyguanosine formation and inter-individual variability by Hodges, N.J., Ádám, B., Lee, A.J., Cross, H.J., Chipman, J.K.

“…Hexavalent chromium [Cr(VI)] is a genotoxic carcinogen for which inhalation is a major potential route of exposure in occupational settings. In the present…”
Get full text