Search Results - "CHINNASAMY, Dhanalakshmi"

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia by Tran, Eric, Chinnasamy, Dhanalakshmi, Yu, Zhiya, Morgan, Richard A, Lee, Chyi-Chia Richard, Restifo, Nicholas P, Rosenberg, Steven A

“…Fibroblast activation protein (FAP) is a candidate universal target antigen because it has been reported to be selectively expressed in nearly all solid tumors…”
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Corrigendum to “Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency” [Neurobiology of Disease 149 (2021) 105224] by Dhanalakshmi, Chinnasamy, Janakiraman, Udaiyappan, Moutal, Aubin, Fukunaga, Kohji, Khanna, Rajesh, Nelson, Mark A.

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IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors by Kerkar, Sid P, Goldszmid, Romina S, Muranski, Pawel, Chinnasamy, Dhanalakshmi, Yu, Zhiya, Reger, Robert N, Leonardi, Anthony J, Morgan, Richard A, Wang, Ena, Marincola, Francesco M, Trinchieri, Giorgio, Rosenberg, Steven A, Restifo, Nicholas P

“…Solid tumors are complex masses with a local microenvironment, or stroma, that supports tumor growth and progression. Among the diverse tumor-supporting…”
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Neurosupportive Role of Vanillin, a Natural Phenolic Compound, on Rotenone Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells by Justin Thenmozhi, Arokiasamy, Nataraj, Jagatheesan, Manivasagam, Thamilarasan, Dhanalakshmi, Chinnasamy, Essa, Musthafa Mohamed

“…Vanillin, a phenolic compound, has been reported to offer neuroprotection against experimental Huntington’s disease and global ischemia by virtue of its…”
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Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency by Dhanalakshmi, Chinnasamy, Janakiraman, Udaiyappan, Moutal, Aubin, Fukunaga, Kohji, Khanna, Rajesh, Nelson, Mark A.

“…The TATA-box binding protein associated factor 1 (TAF1) is part of the TFIID complex that plays a key role during the initiation of transcription. Variants of…”
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The investigation of the T-type calcium channel enhancer SAK3 in an animal model of TAF1 intellectual disability syndrome by Janakiraman, Udaiyappan, Dhanalakshmi, Chinnasamy, Yu, Jie, Moutal, Aubin, Boinon, Lisa, Fukunaga, Kohji, Khanna, Rajesh, Nelson, Mark A.

“…T-type calcium channels, in the central nervous system, are involved in the pathogenesis of many neurodegenerative diseases, including TAF1 intellectual…”
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Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice by Chinnasamy, Dhanalakshmi, Yu, Zhiya, Theoret, Marc R, Zhao, Yangbing, Shrimali, Rajeev K, Morgan, Richard A, Feldman, Steven A, Restifo, Nicholas P, Rosenberg, Steven A

“…Immunotherapies based on adoptive cell transfer are highly effective in the treatment of metastatic melanoma, but the use of this approach in other cancer…”
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TAF1-gene editing alters the morphology and function of the cerebellum and cerebral cortex by Janakiraman, Udaiyappan, Yu, Jie, Moutal, Aubin, Chinnasamy, Dhanalakshmi, Boinon, Lisa, Batchelor, Shelby N., Anandhan, Annaduri, Khanna, Rajesh, Nelson, Mark A.

“…TAF1/MRSX33 intellectual disability syndrome is an X-linked disorder caused by loss-of-function mutations in the TAF1 gene. How these mutations cause…”
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Chronic mild stress augments MPTP induced neurotoxicity in a murine model of Parkinson's disease by Janakiraman, Udaiyappan, Manivasagam, Thamilarasan, Thenmozhi, Arokiasamy Justin, Dhanalakshmi, Chinnasamy, Essa, Musthafa Mohamed, Song, Byoung-Joon, Guillemin, Gilles J

“…Abstract Depression is frequently encountered during Parkinson's disease (PD) as a non-motor feature, which has been reported to cause and exaggerate motor…”
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Correction to: Dietary Supplementation of Walnut Partially Reverses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Neurodegeneration in a Mouse Model of Parkinson’s Disease by Essa, Musthafa Mohamed, Subash, Selvaraju, Dhanalakshmi, Chinnasamy, Manivasagam, Thamilarasan, Al-Adawi, Samir, Guillemin, Gilles J., Thenmozhi, Arokiasamy Justin

“…The original version of this article unfortunately contains an error in Fig. 2a (4th image for walnut). This has been corrected by publishing this erratum…”
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Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI by Chinnasamy, Dhanalakshmi, Milsom, Michael D, Shaffer, James, Neuenfeldt, James, Shaaban, Aimen F, Margison, Geoffrey P, Fairbairn, Leslie J, Chinnasamy, Nachimuthu

“…A number of gene therapy applications would benefit from vectors capable of expressing multiple genes. In this study we explored the feasibility and efficiency…”
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Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells by Ramkumar, Muthu, Rajasankar, Srinivasagam, Gobi, Veerappan Venkatesh, Dhanalakshmi, Chinnasamy, Manivasagam, Thamilarasan, Justin Thenmozhi, Arokiasamy, Essa, Musthafa Mohamed, Kalandar, Ameer, Chidambaram, Ranganathan

“…Mitochondrial dysfunction and oxidative stress are the main toxic events leading to dopaminergic neuronal death in Parkinson's disease (PD) and identified as…”
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Corrigendum to "Evaluation of the effects of the T-type calcium channel enhancer SAK3 in a rat model of TAF1 deficiency" Neurobiology of Disease 149 (2021) 105224 by Dhanalakshmi, Chinnasamy, Janakiraman, Udaiyappan, Moutal, Aubin, Fukunaga, Kohji, Khanna, Rajesh, Nelson, Mark A

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Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer by SHRIMALI, Rajeev K, ZHIYA YU, THEORET, Marc R, CHINNASAMY, Dhanalakshmi, RESTIFO, Nicholas P, ROSENBERG, Steven A

“…Adoptive cell transfer (ACT)-based immunotherapies can mediate objective cancer regression in animal models and in up to 70% of patients with metastatic…”
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Local Delivery of Interleukin-12 Using T Cells Targeting VEGF Receptor-2 Eradicates Multiple Vascularized Tumors in Mice by CHINNASAMY, Dhanalakshmi, ZHIYA YU, KERKAR, Sid P, LING ZHANG, MORGAN, Richard A, RESTIFO, Nicholas P, ROSENBERG, Steven A

“…We investigated the feasibility of delivering the proinflammatory cytokine interleukin (IL)-12 into tumor using T cells genetically engineered to express a…”
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Simultaneous Targeting of Tumor Antigens and the Tumor Vasculature Using T Lymphocyte Transfer Synergize to Induce Regression of Established Tumors in Mice by CHINNASAMY, Dhanalakshmi, TRAN, Eric, ZHIYA YU, MORGAN, Richard A, RESTIFO, Nicholas P, ROSENBERG, Steven A

“…Most systemic cancer therapies target tumor cells directly, although there is increasing interest in targeting the tumor stroma that can comprise a substantial…”
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Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson’s Disease by Dhanalakshmi, Chinnasamy, Janakiraman, Udaiyappan, Manivasagam, Thamilarasan, Justin Thenmozhi, Arokiasamy, Essa, Musthafa Mohamed, Kalandar, Ameer, Khan, Mohammed Abdul Sattar, Guillemin, Gilles J.

“…Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic…”
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CNB-001, a novel pyrazole derivative mitigates motor impairments associated with neurodegeneration via suppression of neuroinflammatory and apoptotic response in experimental Parkinson’s disease mice by Jayaraj, Richard L., Elangovan, Namasivayam, Dhanalakshmi, Chinnasamy, Manivasagam, Thamilarasan, Essa, Musthafa Mohamed

“…•CNB-001, a novel derivative of curcumin attenuates MPTP induced behavioral impairment by protecting dopaminergic neurons.•CNB-001 inhibits inflammatory…”
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Dietary Supplementation of Walnut Partially Reverses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Neurodegeneration in a Mouse Model of Parkinson’s Disease by Essa, Musthafa Mohamed, Subash, Selvaraju, Dhanalakshmi, Chinnasamy, Manivasagam, Thamilarasan, Al-Adawi, Samir, Guillemin, Gilles J., Thenmozhi, Arokiasamy Justin

“…Numerous studies indicating that natural plant sources and their active phytochemicals offer protection to the pathological processes related to the…”
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Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice by Venkatesh Gobi, Veerappan, Rajasankar, Srinivasagam, Ramkumar, Muthu, Dhanalakshmi, Chinnasamy, Manivasagam, Thamilarasan, Justin Thenmozhi, Arokiasamy, Essa, Musthafa Mohamed, Chidambaram, Ranganathan, Kalandar, Ameer

“…Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson's…”
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