Search Results - "CHINJE, E. C"

Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069 by PATTERSON, A. V, SAUNDERS, M. P, CHINJE, E. C, TALBOT, D. C, HARRIS, A. L, STRATFORD, I. J

“…P450 reductase (NADPH: cytochrome c (P450) reductase, EC 1.6.2.4) plays an important role in the reductive activation of the bioreductive drug tirapazamine…”
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NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line by SAUNDERS, M. P, PATTERSON, A. V, CHINJE, E. C, HARRIS, A. L, STRATFORD, I. J

“…Tirapazamine (TPZ, SR4233, WIN 59075) is a bioreductive drug that is activated in regions of low oxygen tension to a cytotoxic radical intermediate. This…”
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Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents by GARNER, A. P, PAINE, M. J. I, RODRIGUEZ-CRESPO, I, CHINJE, E. C, ORTIZ DE MONTELLANO, P, STRATFORD, I. J, TEW, D. G, WOLF, C. R

“…Nitric oxide synthases (NOSs) play a crucial role in the control of blood flow, memory formation, and the immune response. These proteins can be structurally…”
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Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233) by PATTERSON, A. V, BARHAM, H. M, CHINJE, E. C, ADAMS, G. E, HARRIS, A. L, STRATFORD, I. J

“…P450 reductase (NADPH:cytochrome P450 reductase, EC 1.6.2.4) is known to be important in the reductive activation of the benzotriazene-di-N-oxide tirapazamine…”
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17β-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response by CHINJE, E. C, WILLIAMS, K. J, TELFER, B. A, WOOD, P. J, VAN DER KOGEL, A. J, STRATFORD, I. J

“…The putative oestrogen receptor negative human breast cancer cell line MDA231, when grown as tumours in mice continually receiving 17β-oestradiol, showed…”
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Does reductive metabolism predict response to tirapazamine (SR 4233) in human non-small-cell lung cancer cell lines? by CHINJE, E. C, PATTERSON, A. V, SAUNDERS, M. P, LOCKYER, S. D, HARRIS, A. L, STRATFORD, I. J

“…The bioreductive drug tirapazamine (TPZ, SR 4233, WIN 59075) is a lead compound in a series of potent cytotoxins that selectively kill hypoxic rodent and human…”
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Development and validation of a spectrophotometric assay for measuring the activity of NADH: cytochrome b5 reductase in human tumour cells by BARHAM, H. M, INGLIS, R, CHINJE, E. C, STRAFORD, I. J

“…As part of an 'enzyme-directed' approach to bioreductive drug development, we have measured the activity of NADH: cytochrome b5 reductase (B5R) in human cancer…”
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Enzymology of tirapazamine metabolism: a review by Patterson, A V, Saunders, M P, Chinje, E C, Patterson, L H, Stratford, I J

“…The enzymology of triapazamine (TPZ, SR 4233, WIN 59075, 3-amino-1,2,4-benzotriazene 1,4-dioxide, Tirazone) has been extensively studied in rodents and to a…”
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Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: Reversing tumor radioresistance and effecting cure by COWEN, Rachel L, WILLIAMS, Kaye J, CHINJE, Edwin C, JAFFAR, Mohammed, SHEPPARD, Freda C. D, TELFER, Brian A, WIND, Natasha S, STRATFORD, Ian J

“…Solid tumors are characterized by regions of hypoxia that are inherently resistant to both radiotherapy and some chemotherapy. To target this resistant…”
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Role of nitric oxide in growth of solid tumours: a balancing act by Chinje, E C, Stratford, I J

“…NO synthases are unique among eukaryotic enzymes in being dimeric, calmodulin-dependent or calmodulin-containing cytochrome P-450-like haemoproteins that…”
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S-2-amino-5-(2-nitroimidazol-1-yl)pentanoic acid: a model for potential bioreductively activated prodrugs for inhibitors of nitric oxide synthase (NOS) activity by Ulhaq, S, Naylor, M A, Chinje, E C, Threadgill, M D, Stratford, I J

“…Treatment of 1,1-dimethylethyl S-(2-1,1-dimethylethoxycarbonylamino)-5-bromopentanoate with 1-potassio-2-nitroimidazole, followed by deprotection, afforded…”
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Heterocyclic analogues of L-citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of Nδ-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor by ULHAQ, S, CHINJE, E. C, NAYLOR, M. A, JAFFAR, M, STRATFORD, I. J, THREADGILL, M. D

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S-2-Amino-5-azolylpentanoic Acids Related to l-Ornithine as inhibitors of the isoforms of nitric oxide synthase (NOS) by Ulhaq, Saraj, Chinje, Edwin C., Naylor, Matthew A., Jaffar, Mohammed, Stratford, Ian J., Threadgill, Michael D.

“…S-2-Amino-5-(2-aminoimidazol-1-yl)pentanoic acid and S-2-amino-5-(2-nitroimidazol-1-yl)pentanoic acid have been used as weakly inhibitory lead compounds in the…”
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Possible chloroquine-induced modification of N-acetylation of isoniazid and sulphadimidine in the rat by Nwankwo, J O, Garba, M A, Chinje, C E, Mgbojikwe, L O, Emerole, G O

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17beta-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response by Chinje, E C, Williams, K J, Telfer, B A, Wood, P J, van der Kogel, A J, Stratford, I J

“…The putative oestrogen receptor negative human breast cancer cell line MDA231, when grown as tumours in mice continually receiving 17beta-oestradiol, showed…”
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17b-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response by Chinje, E C, Williams, K J, Telfer, B A, Wood, P J, van der Kogel, A J, Stratford, I J

“…The putative oestrogen receptor negative human breast cancer cell line MDA231, when grown as tumours in mice continually receiving 17b-oestradiol, showed…”
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17[beta]-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response by Chinje, E C, Williams, K J, Telfer, B A, Wood, P J, A J van der Kogel, Stratford, I J

“…The putative oestrogen receptor negative human breast cancer cell line MDA231, when grown as tumours in mice continually receiving 17beta-oestradiol, showed…”
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Heterocyclic analogues of L-citrulline as inhibitors of the isoforms of nitric oxide synthase (NOS) and identification of N(delta)-(4,5-dihydrothiazol-2-yl)ornithine as a potent inhibitor by Ulhaq, S, Chinje, E C, Naylor, M A, Jaffar, M, Stratford, I J, Threadgill, M D

“…L-Thiocitrulline is a known potent inhibitor of several isoforms of nitric oxide synthase (NOS). To explore the structure-activity relationships (SARs) for…”
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CANCER CHEMOTHERAPY AND DRUG METABOLISM by Riddick, David S, Lee, Chunja, Ramji, Shairoz, Chinje, Edwin C, Cowen, Rachel L, Williams, Kaye J, Patterson, Adam V, Stratford, Ian J, Morrow, Charles S, Townsend, Alan J, Jounaidi, Youssef, Chen, Chong-Sheng, Su, Ting, Lu, Hong, Schwartz, Pamela S, Waxman, David J

“…Drug-metabolizing enzymes and drug transporters are key determinants of the pharmacokinetics and pharmacodynamics of many antineoplastic agents. Metabolism and…”
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Synthesis of N-benzyl- and N-phenyl-2-amino-4,5-dihydrothiazoles and thioureas and evaluation as modulators of the isoforms of nitric oxide synthase by Goodyer, Claire L.M., Chinje, Edwin C., Jaffar, Mohammed, Stratford, Ian J., Threadgill, Michael D.

“…Inhibition of the isoforms of nitric oxide synthase (NOS) has important applications in therapy of several diseases, including cancer. Using 1400W […”
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